Title:
EXTRACELLULAR MATRIX-BASED HYDROGEL AND SPONGE FOR WOUND HEALING OR TISSUE REGENERATION, AND PRODUCTION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2024/014795
Kind Code:
A1
Abstract:
The present invention relates to: a method for producing a hydrogel prepared from an extracellular matrix without a separate polymer support or a hydrogel precursor solution; a hydrogel produced therefrom; a sponge produced by freeze-drying same; use of the hydrogel for wound healing and tissue regeneration; and the like. The extracellular matrix-based hydrogel and sponge of the present invention have high biocompatibility, physical stability and mechanical properties and include various bioactive substances including angiogenic factors, and thus are very effective in wound treatment such as that of tissue regeneration and inflammation control. Therefore, the extracellular matrix-based hydrogel and sponge of the present invention are expected to be used in the fields of regenerative medicine, burns and wound treatment, and the like.
Inventors:
PARK KWI DEOK (KR)
HA SANG SU (KR)
KWON JAE WON (KR)
CININTA SAVITRI (KR)
HA SANG SU (KR)
KWON JAE WON (KR)
CININTA SAVITRI (KR)
Application Number:
PCT/KR2023/009718
Publication Date:
January 18, 2024
Filing Date:
July 10, 2023
Export Citation:
Assignee:
KOREA INST SCI & TECH (KR)
International Classes:
A61L27/52; A61K9/06; A61L26/00; A61L27/36; A61L27/50; A61L27/54; A61P17/02
Foreign References:
| KR20220019366A | 2022-02-17 | |||
| KR102159345B1 | 2020-09-23 |
Other References:
"Ph.D. thesis", 1 January 2022, UNIVERSITY OF SCIENCE AND TECHNOLOGY (UST), Korea, article SAVITRI, C.: "Investigation of Macrophage-Extracellular Matrix Interactions and the Impact on Wound Healing", pages: 1 - 133, XP009552173
WANG FANGFANG; ZHANG RUI; GAO NIUNIU; CHANG CHUNYU; WANG ZONGHUAN; ZHOU YINGJIE; ZHANG CHI; MA JIANWEI; JIN YONG; WEI PENG; MEI JI: "Coagulation/anticoagulation-regulable and tough extracellular matrix hydrogels", COMPOSITES PART B, ELSEVIER, AMSTERDAM, NL, vol. 239, 26 April 2022 (2022-04-26), AMSTERDAM, NL, XP087082799, ISSN: 1359-8368, DOI: 10.1016/j.compositesb.2022.109938
KIM HYO-SUNG, HWANG HYUN-JEONG, KIM HAN-JUN, CHOI YEJI, LEE DAEHYUNG, JUNG HONG-HEE, DO SUN HEE: "Effect of Decellularized Extracellular Matrix Bioscaffolds Derived from Fibroblasts on Skin Wound Healing and Remodeling", FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, FRONTIERS RESEARCH FOUNDATION, CH, vol. 10, 29 June 2022 (2022-06-29), CH , pages 865545, XP093128489, ISSN: 2296-4185, DOI: 10.3389/fbioe.2022.
WANG FANGFANG; ZHANG RUI; GAO NIUNIU; CHANG CHUNYU; WANG ZONGHUAN; ZHOU YINGJIE; ZHANG CHI; MA JIANWEI; JIN YONG; WEI PENG; MEI JI: "Coagulation/anticoagulation-regulable and tough extracellular matrix hydrogels", COMPOSITES PART B, ELSEVIER, AMSTERDAM, NL, vol. 239, 26 April 2022 (2022-04-26), AMSTERDAM, NL, XP087082799, ISSN: 1359-8368, DOI: 10.1016/j.compositesb.2022.109938
KIM HYO-SUNG, HWANG HYUN-JEONG, KIM HAN-JUN, CHOI YEJI, LEE DAEHYUNG, JUNG HONG-HEE, DO SUN HEE: "Effect of Decellularized Extracellular Matrix Bioscaffolds Derived from Fibroblasts on Skin Wound Healing and Remodeling", FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, FRONTIERS RESEARCH FOUNDATION, CH, vol. 10, 29 June 2022 (2022-06-29), CH , pages 865545, XP093128489, ISSN: 2296-4185, DOI: 10.3389/fbioe.2022.
Attorney, Agent or Firm:
MUHANN PATENT & LAW FIRM (KR)
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