Title:
EXTRACTIVE SOLUTION CRYSTALLIZATION OF CHEMICAL COMPOUNDS
Document Type and Number:
WIPO Patent Application WO2001094302
Kind Code:
A3
Abstract:
A process for the purification and isolation of a chemical compound, by extractive solution crystallization. The process comprises combining in any order a first solvent, a second solvent, and a mixture comprising a chemical compound with at least one impurity. The second solvent phase extracts impurities out of the first solvent, and keeps the impurities dissolved to avoid their co-crystallization with the phenyl ester salt. Once the chemical compound has crystallized out of solution, it is collected, washed and/or dried. The second solvent may be added after the mixture containing at least one chemical compound is dissolved in a first solvent, as long as the second solvent phase is added prior to the end of crystallization. Advantageously, this invention combines the previously distinct steps of extraction and crystallization in one unit operation. The process may be used with a variety of chemical compounds particularly, phenyl ester salts, including but not limited to sodium 4-sulfophenyl-6-[(1-oxynonyl)amino] hexanoate, sodium 4-(nonanoyloxy) benzenesulfonate, and sodium benzoyloxybenzenesulphonate.
Inventors:
FONTENOT KEVIN J
Application Number:
PCT/US2001/017968
Publication Date:
May 30, 2002
Filing Date:
June 04, 2001
Export Citation:
Assignee:
EASTMAN CHEM CO (US)
International Classes:
C07C303/44; B01D9/00; C07C309/42; (IPC1-7): C07C303/44; C07C309/42
Domestic Patent References:
| WO1994028106A1 | 1994-12-08 |
Foreign References:
| US2941019A | 1960-06-14 |
Other References:
PATENT ABSTRACTS OF JAPAN vol. 1997, no. 08 29 August 1997 (1997-08-29)
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