Title:
A-FABP PROTEIN INHIBITOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/082397
Kind Code:
A1
Abstract:
Disclosed are an A-FABP protein inhibitor and a use thereof, relating to the technical field of metabolic diseases, and cardiovascular and cerebrovascular complications thereof. Disclosed is an A-FABP protein inhibitor, an active ingredient of the A-FABP protein inhibitor being cobimetinib. The commercially available drug cobimetinib is used for targeted inhibition of the protein A-FABP. Pro-inflammatory biological activity of the protein A-FABP is inhibited by means of inhibiting phosphorylation of a JNK/c-Jun signaling pathway. Development of a novel use of an existing drug leads to significantly reduced costs of early-stage research and development and drastically reduced research and development period. Research results provide candidate medicines for various metabolic diseases.
Inventors:
CHANG JUNLEI (CN)
YANG SHILUN (CN)
LI SIMENG (CN)
YANG SHILUN (CN)
LI SIMENG (CN)
Application Number:
PCT/CN2021/137800
Publication Date:
May 19, 2023
Filing Date:
December 14, 2021
Export Citation:
Assignee:
SHENZHEN INST OF ADV TECH CAS (CN)
International Classes:
A61K31/4523; A61P1/16; A61P3/00; A61P3/06; A61P3/10; A61P7/00; A61P9/00; A61P9/10; C07D401/04; G06N20/00; G16B25/00
Domestic Patent References:
| WO2020225147A1 | 2020-11-12 | |||
| WO2006047759A2 | 2006-05-04 |
Foreign References:
| CN110151763A | 2019-08-23 | |||
| CN111826431A | 2020-10-27 | |||
| US20160113937A1 | 2016-04-28 |
Other References:
WANG, YAN ET AL.: "Using molecular docking screening for identifying hyperoside as an inhibitor of fatty acid binding protein 4 from a natural product database", JOURNAL OF FUNCTIONAL FOODS, vol. 20, 17 November 2015 (2015-11-17), pages 159 - 170, XP029360126, DOI: 10.1016/j.jff.2015.10.031
梁停停 等 (LIANG, TINGTING ET AL.): "小分子ERK抑制剂的研究进展 (Research Progress of ERK Small Molecule Inhibitors)", 中国药科大学学报 (JOURNAL OF CHINA PHARMACEUTICAL UNIVERSITY), vol. 51, no. 3, 31 December 2020 (2020-12-31), pages 260 - 269
梁停停 等 (LIANG, TINGTING ET AL.): "小分子ERK抑制剂的研究进展 (Research Progress of ERK Small Molecule Inhibitors)", 中国药科大学学报 (JOURNAL OF CHINA PHARMACEUTICAL UNIVERSITY), vol. 51, no. 3, 31 December 2020 (2020-12-31), pages 260 - 269
Attorney, Agent or Firm:
BEIJING ZHONG XUN TONG DA INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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