Title:
FABRICATION OF FLUORESCENT NANOPARTICLES AND THEIR CONJUGATES FOR IN VITRO AND IN VIVO DIAGNOSTICS
Document Type and Number:
WIPO Patent Application WO/2021/017904
Kind Code:
A1
Abstract:
Provided are fluorescent nanoparticles and their conjugates and methods of using the same for in vivo and in vitro diagnostics and other applications. In some embodiments, provided are fluorescent nanoparticles with high solid-state absolute quantum yield. In some embodiments, provided are methods of manufacturing such nanoparticles. Nanoparticles may comprise monomers, such as styrene, and fluorophores, such as AIEgen TM Bright Green.
More Like This:
Inventors:
XIE NI (CN)
TANG BENZHONG (CN)
TANG BENZHONG (CN)
Application Number:
PCT/CN2020/102815
Publication Date:
February 04, 2021
Filing Date:
July 17, 2020
Export Citation:
Assignee:
AUISET BIOTECHNOLOGY CO LTD (CN)
International Classes:
G01N21/64; C07D207/448; C09B62/343
Domestic Patent References:
| WO2015018322A1 | 2015-02-12 |
Foreign References:
| CN1394882A | 2003-02-05 | |||
| CN1643379A | 2005-07-20 |
Other References:
YANG， TIANSHE ET. AL.: "Polymer nanoparticles with an embedded phosphorescent osmium(II) complex for cell imaging", JOURNAL OF MATERIALS CHEMISTRY, vol. 21, 11 February 2011 (2011-02-11), XP055776772
FUKUI， CHIAKI ET. AL: "Fluorescent p-conjugated polymer nanoparticles: A new synthetic approach based on nanoagglomeration via polyion association", MATERIALS RESEARCH SOCIETY, vol. 30, no. 1, 14 January 2015 (2015-01-14), pages 10 - 18, XP055776785
HILL， SAMANTHA ET. AL.: "Silicon quantum dot - poly(methyl methacrylate) nanocomposites with reduced light scattering for luminescent solar concentrators", ACS. PHOTONICS, 4 December 2018 (2018-12-04), pages 1 - 29, XP055776778
SHEVCHENKO， N. N. ET. AL.: "Luminophore-Containing Polymer Particles:Synthesis and Optical Properties of Thin Films on Their Basis", NANOTECHNOLOGIES IN RUSSIA, vol. 7, no. 3-4, 31 December 2012 (2012-12-31), XP055776780
SHIMIZU， MASAKI ET.AL.: "Use of silylmethoxy groups as inducers of efficient room temperature phosphorescence from precious-metal-free organic luminophores", MATERIALS CHEMISTRY FRONTIERS, vol. 00, no. 1-3, 14 December 2017 (2017-12-14), pages 1 - 8, XP055776787
PONOMARENKO， SERGEI A. ET. AL.: "Nanostructured organosilicon luminophores and their application in highly efficient plastic scintillators", SCIENTIFIC REPORTS, 8 October 2014 (2014-10-08), pages 1 - 8, XP055776789
YANG， TIANSHE ET. AL.: "Polymer nanoparticles with an embedded phosphorescent osmium(II) complex for cell imaging", JOURNAL OF MATERIALS CHEMISTRY, vol. 21, 11 February 2011 (2011-02-11), XP055776772
HAN， FANGFANG ET. AL.: "A new TICT and AIE-active tetraphenylethenebased Schiff base with reversible piezofluorochromism", ROYAL SOCIETY OF CHEMISTRY, vol. 6, 13 July 2016 (2016-07-13), XP055776796
FUKUI， CHIAKI ET. AL: "Fluorescent p-conjugated polymer nanoparticles: A new synthetic approach based on nanoagglomeration via polyion association", MATERIALS RESEARCH SOCIETY, vol. 30, no. 1, 14 January 2015 (2015-01-14), pages 10 - 18, XP055776785
HILL， SAMANTHA ET. AL.: "Silicon quantum dot - poly(methyl methacrylate) nanocomposites with reduced light scattering for luminescent solar concentrators", ACS. PHOTONICS, 4 December 2018 (2018-12-04), pages 1 - 29, XP055776778
SHEVCHENKO， N. N. ET. AL.: "Luminophore-Containing Polymer Particles:Synthesis and Optical Properties of Thin Films on Their Basis", NANOTECHNOLOGIES IN RUSSIA, vol. 7, no. 3-4, 31 December 2012 (2012-12-31), XP055776780
SHIMIZU， MASAKI ET.AL.: "Use of silylmethoxy groups as inducers of efficient room temperature phosphorescence from precious-metal-free organic luminophores", MATERIALS CHEMISTRY FRONTIERS, vol. 00, no. 1-3, 14 December 2017 (2017-12-14), pages 1 - 8, XP055776787
PONOMARENKO， SERGEI A. ET. AL.: "Nanostructured organosilicon luminophores and their application in highly efficient plastic scintillators", SCIENTIFIC REPORTS, 8 October 2014 (2014-10-08), pages 1 - 8, XP055776789
YANG， TIANSHE ET. AL.: "Polymer nanoparticles with an embedded phosphorescent osmium(II) complex for cell imaging", JOURNAL OF MATERIALS CHEMISTRY, vol. 21, 11 February 2011 (2011-02-11), XP055776772
HAN， FANGFANG ET. AL.: "A new TICT and AIE-active tetraphenylethenebased Schiff base with reversible piezofluorochromism", ROYAL SOCIETY OF CHEMISTRY, vol. 6, 13 July 2016 (2016-07-13), XP055776796
Attorney, Agent or Firm:
SHENZHEN STANDARD PATENT & TRADEMARK AGENT LTD. (CN)
Download PDF:
Previous Patent: VOICE CALL METHOD, APPARATUS AND SYSTEM
Next Patent: BATTERY, BATTERY CELL, AND TOP COVER ASSEMBLY THEREOF
Next Patent: BATTERY, BATTERY CELL, AND TOP COVER ASSEMBLY THEREOF