Title:
FARNESYL PROTEIN TRANSFERASE INHIBITOR COMBINATIONS WITH PLATINUM COMPOUNDS
Document Type and Number:
WIPO Patent Application WO2001064226
Kind Code:
A3
Abstract:
The present invention is concerned with combinations of a farnesyl transferase inhibitor and a platinum compound for inhibiting the growth of tumor cells and useful in the treatment of cancer.
Inventors:
PALMER PETER ALBERT (BE)
HORAK IVAN DAVID (US)
HORAK IVAN DAVID (US)
Application Number:
PCT/EP2001/002160
Publication Date:
March 07, 2002
Filing Date:
February 26, 2001
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NV (BE)
PALMER PETER ALBERT (BE)
HORAK IVAN DAVID (US)
PALMER PETER ALBERT (BE)
HORAK IVAN DAVID (US)
International Classes:
C07D487/04; A61K31/282; A61K31/47; A61K31/4709; A61K31/519; A61K31/55; A61K33/243; A61P35/00; A61P35/02; A61P43/00; C07D401/06; (IPC1-7): A61K33/24; A61K31/55; A61K31/47; A61P35/00
Domestic Patent References:
| WO1999032114A1 | 1999-07-01 | |||
| WO2000001382A1 | 2000-01-13 | |||
| WO1997021701A1 | 1997-06-19 | |||
| WO1997016443A1 | 1997-05-09 | |||
| WO1998049157A1 | 1998-11-05 | |||
| WO1998040383A1 | 1998-09-17 | |||
| WO2000039082A2 | 2000-07-06 | |||
| WO1999065494A1 | 1999-12-23 |
Other References:
ZUJEWSKI J ET AL: "PHASE 1 AND PHAMACOKINETIC STUDY OF FARNESYL PROTEIN TRANSFERASE INHIBITOR R115777 IN ADVANCED CANCER", JOURNAL OF CLINICAL ONCOLOGY, PHILADELPHIA, PA, US, vol. 18, no. 4, February 2000 (2000-02-01), pages 927 - 941, XP000956079
SKRZAT S G ET AL: "INTERACTION OF THE FARNESYL PROTEIN TRANSFERASE INHIBITOR (FTI) R115777 WITH CYTOTOXIC CHEMOTHERAPEUTICS IN VITRO AND IN VIVO", PROCEEDINGS OF THE 90TH ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH. PHILADELPHIA, PA, APRIL 10 - 14, 1999, PROCEEDINGS OF THE ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, PHILADELPHIA, PA: AACR, US, vol. 40, March 1999 (1999-03-01), pages 523, XP000929795
SCHELLENS J H M ET AL: "PHASE I AND PHARMACOLOGIC STUDY WITH THE NOVEL FARNESYLTRANSFERASE INHIBITOR (FTI) R15777", SHIPBUILDING AND SHIPPING RECORD, IP INDUSTRIAL PRESS LTD. LONDON, GB, vol. 40, March 1999 (1999-03-01), pages 724, XP000952727
SUN J ET AL: "ANTITUMOUR EFFICACY OF A NOVEL CLASS OF NON-THIOL-CONTAINING PEPTIDOMIMETIC INHIBITORS OF FARNESYLTRANSFERASE AND GERANYLGERANYLTRANSFERASE I: COMBINATION THERAPY WITH THE CYTOTOXICAGENTS CISPLATIN, TAXOL, AND GEMCITABINE", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 59, no. 19, 1 October 1999 (1999-10-01), pages 4919 - 4926, XP000919398, ISSN: 0008-5472
SKRZAT S G ET AL: "INTERACTION OF THE FARNESYL PROTEIN TRANSFERASE INHIBITOR (FTI) R115777 WITH CYTOTOXIC CHEMOTHERAPEUTICS IN VITRO AND IN VIVO", PROCEEDINGS OF THE 90TH ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH. PHILADELPHIA, PA, APRIL 10 - 14, 1999, PROCEEDINGS OF THE ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, PHILADELPHIA, PA: AACR, US, vol. 40, March 1999 (1999-03-01), pages 523, XP000929795
SCHELLENS J H M ET AL: "PHASE I AND PHARMACOLOGIC STUDY WITH THE NOVEL FARNESYLTRANSFERASE INHIBITOR (FTI) R15777", SHIPBUILDING AND SHIPPING RECORD, IP INDUSTRIAL PRESS LTD. LONDON, GB, vol. 40, March 1999 (1999-03-01), pages 724, XP000952727
SUN J ET AL: "ANTITUMOUR EFFICACY OF A NOVEL CLASS OF NON-THIOL-CONTAINING PEPTIDOMIMETIC INHIBITORS OF FARNESYLTRANSFERASE AND GERANYLGERANYLTRANSFERASE I: COMBINATION THERAPY WITH THE CYTOTOXICAGENTS CISPLATIN, TAXOL, AND GEMCITABINE", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 59, no. 19, 1 October 1999 (1999-10-01), pages 4919 - 4926, XP000919398, ISSN: 0008-5472
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