Title:
FAT EMULSION DIALYSATE, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/147962
Kind Code:
A1
Abstract:
The present invention relates to the field of hemodialysis, in particular to a fat emulsion dialysate, and a preparation method therefor and the use thereof. Provided in the present invention is a fat emulsion dialysate, comprising long-chain fat emulsion oil, medium-chain triglyceride, an antioxidant, sodium oleate, glycerol, phospholipid and a solvent. Compared with traditional dialysis, the fat emulsion dialysate provided by the present invention clearly has a better removal advantage for protein-bound toxins. In addition, the fat emulsion dialysate not only has a simple preparation method and a low cost, but also has good stability and safety, and remains stable at room temperature for 14 days without obvious precipitation. Thus, the fat emulsion dialysate can become a new hemodialysis solution with broad application prospects, and has good industrialization prospects.
Inventors:
DING FENG (CN)
WANG YIFENG (CN)
SHEN YUQI (CN)
WANG YIFENG (CN)
SHEN YUQI (CN)
Application Number:
PCT/CN2021/099563
Publication Date:
July 14, 2022
Filing Date:
June 11, 2021
Export Citation:
Assignee:
SHANGHAI 9TH PEOPLES HOSPITAL SHANGHAI JIAOTONG UNIV SCHOOL MEDICINE (CN)
International Classes:
A61K9/107; A61P7/08; A61P13/12
Domestic Patent References:
| WO2020018512A1 | 2020-01-23 |
Foreign References:
| CN1965806A | 2007-05-23 | |||
| CN102348469A | 2012-02-08 | |||
| CN101244037A | 2008-08-20 | |||
| CN1376460A | 2002-10-30 | |||
| CN111821263A | 2020-10-27 | |||
| CN101312712A | 2008-11-26 | |||
| CN101190248A | 2008-06-04 | |||
| CN109589306A | 2019-04-09 |
Other References:
SHI YUANYUAN, ZHANG YUMEI, TIAN HUAJUN, WANG YIFENG, SHEN YUE, ZHU QIUYU, DING FENG: "Improved dialytic removal of protein-bound uremic toxins by intravenous lipid emulsion in chronic kidney disease rats", NEPHROLOGY DIALYSIS TRANSPLANTATION, OXFORD UNIVERSITY PRESS, GB, vol. 34, no. 11, 1 November 2019 (2019-11-01), GB , pages 1842 - 1852, XP055949678, ISSN: 0931-0509, DOI: 10.1093/ndt/gfz079
SHI XUE-FENG, DING FENG, GU YONG, ZHU QIU-YU, PAN JUN, LU WEI-YUE: "Preliminary examination on removal of protein-bound toxins by hemolipodialysis", FUDAN XUEBAO (YIXUE BAN) /, FUDAN UNIVERSITY MEDICAL SCIENCES. JOURNAL (MEDICAL SCIENCE), CN, vol. 33, no. 2, 30 March 2006 (2006-03-30), CN , pages 213 - 216, XP055949679, ISSN: 1672-8467
"Chinese Pharmacopoeia", vol. 2, 2015
CAS, no. 93685-90-6
SHI XUE-FENG, DING FENG, GU YONG, ZHU QIU-YU, PAN JUN, LU WEI-YUE: "Preliminary examination on removal of protein-bound toxins by hemolipodialysis", FUDAN XUEBAO (YIXUE BAN) /, FUDAN UNIVERSITY MEDICAL SCIENCES. JOURNAL (MEDICAL SCIENCE), CN, vol. 33, no. 2, 30 March 2006 (2006-03-30), CN , pages 213 - 216, XP055949679, ISSN: 1672-8467
"Chinese Pharmacopoeia", vol. 2, 2015
CAS, no. 93685-90-6
Attorney, Agent or Firm:
J.Z.M.C. PATENT AND TRADEMARK LAW OFFICE (GENERAL PARTNERSHIP) (CN)
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