FENLEAN (FLZ) CRYSTAL B FORM, PREPARATION METHOD, AND COMPOSITION AND USE THEREOF

WIPO Patent Application WO/2019/011349

A1

Disclosed are an FLZ crystal B form, a preparation method, and a composition and the use thereof, in particular the crystal B form of an FLZ compound (I) (chemical name: trans-2-(2,5-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenyl-ethyl)acrylamide), a preparation method therefor, and the composition and the use thereof. In particular, disclosed are the crystal B form solid matter of FLZ in a solid state; the method for preparing the crystal B form solid matter; and the use of the FLZ crystal B form solid matter as a pharmaceutically active ingredient in the preparation of a preventive drug for resisting Parkinson's disease (PD), improving learning and memory disorders, treating memory ability decline and Alzheimer's disease (AD).

WO/2000/041993	NOVEL 1,2-DIPHENYL-2-PROPEN-1-ONE DERIVATIVES
WO/1992/019587	METHOD OF PRODUCING AN AMIDE PRODUCT MIXTURE, AN AMIDE PRODUCT MIXTURE AND THE USE THEREOF
WO/1995/031977	NOVEL POTENT INDUCERS OF TERMINAL DIFFERENTIATION AND METHODS OF USE THEREOF

LV YANG (CN)
YANG SHIYING (CN)
LIU GENGTAO (CN)
ZHANG DAN (CN)
BAO XIUQI (CN)
XIE PING (CN)

PCT/CN2018/104573

January 17, 2019

September 07, 2018

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INST MATERIA MEDICA CAMS (CN)
SHIJIAZHUANG YILING PHARMACEUTICAL CO LTD (CN)

C07C233/17; A61K31/165; A61P25/16; C07C233/01; C07C235/34

CN1445211A	2003-10-01
CN1445211A	2003-10-01

JI, . XIAOSHEN ET ET AL.: "Studies . on Total Synthesis of Squamosamide", ACTA PHARMACEUTICA SINICA, vol. 28, no. 6, 30 June 1993 (1993-06-30), pages 428 - 431, XP009518870, ISSN: 0513-4870
See also references of EP 3653601A4

BEIJING SANYOU INTELLECTUAL PROPERTY AGENCY LTD. (CN)

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