Title:
FERMENTATION PROCESS FOR ANTIBODY PRODUCTION
Document Type and Number:
WIPO Patent Application WO/2014/145521
Kind Code:
A3
Abstract:
A feedback control mechanism for a fermentation of yeast cells to make recombinant proteins uses a respiratory quotient measurement which adjusts the levels of oxygenation and/or fermentable sugar feed. The feedback control mechanism permits well controlled cultures that produce good amounts of product while avoiding toxic accumulation of ethanol. Additionally, recombinant proteins so produced have excellent qualitative properties, such as excellent homogeneity and proper inter-subunit assembly.
Inventors:
LESNICKI GARY (US)
MCNEILL PATRICIA DIANNE (US)
HARTNER FRANZ (AT)
YOUNG MARK (US)
MCNEILL PATRICIA DIANNE (US)
HARTNER FRANZ (AT)
YOUNG MARK (US)
Application Number:
PCT/US2014/030311
Publication Date:
December 24, 2014
Filing Date:
March 17, 2014
Export Citation:
Assignee:
ALDERBIO HOLDINGS LLC (US)
International Classes:
C12N1/15; C12N1/19; C12P21/08
Domestic Patent References:
| WO2012049179A2 | 2012-04-19 |
Foreign References:
| US20100112639A1 | 2010-05-06 | |||
| EP0537897A1 | 1993-04-21 | |||
| US6220076B1 | 2001-04-24 | |||
| US7892825B2 | 2011-02-22 | |||
| JP2006288201A | 2006-10-26 | |||
| US20110014650A1 | 2011-01-20 |
Attorney, Agent or Firm:
KAGAN, Sarah A. (1100 13TH Street, N.W.,Suite 120, Washington District of Columbia, US)
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