Title:
FERROPTOSIS INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2022/075444
Kind Code:
A1
Abstract:
A problem addressed by the present invention is to provide a low-molecular compound that has relatively high safety when ingested, that can be ingested orally, that can be produced relatively inexpensively, and that has anti-ferroptosis activity and an ability to scavenge lipid peroxy radicals. A ferroptosis inhibitor that includes one or more compounds selected from the group consisting of compounds represented by formulas (I)-(III) and physiologically acceptable salts thereof; an agent for the prevention or treatment of a disease associated with ferroptosis; a lipid peroxy radical scavenger; or an agent for the prevention or treatment of a disease caused by lipid peroxide accumulation and/or lipid peroxy radicals. (In the formulas; R represents H; a substituted or unsubstituted linear or branched C1-20 alkyl group; a substituted or unsubstituted linear or branched C2-20 alkenyl group; or –(CH2CH=CH(CH3)CH2)nH (in the formula, n represents an integer of 1-12).)
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Inventors:
MISHIMA EIKAN (JP)
NAKAGAWA KIYOTAKA (JP)
ITO JUNYA (JP)
YAMADA KENICHI (JP)
NAKAGAWA KIYOTAKA (JP)
ITO JUNYA (JP)
YAMADA KENICHI (JP)
Application Number:
PCT/JP2021/037317
Publication Date:
April 14, 2022
Filing Date:
October 08, 2021
Export Citation:
Assignee:
UNIV TOHOKU (JP)
International Classes:
A61K31/05; A61K31/122; A61K31/336; A61P1/16; A61P3/00; A61P3/02; A61P39/06; A61P43/00
Foreign References:
| JP2019227405A | 2019-12-17 | |||
| JP2019196390A | 2019-11-14 |
Other References:
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BIOORG MED CHEM LETT, vol. 22, 2012, pages 1822 - 1826
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CELL, vol. 149, 2012, pages 1060 - 1072
VERVOORT LILY M.T, RONDEN JACINTHA E, THIJSSEN HENK H.W: "The potent antioxidant activity of the vitamin K cycle in microsomal lipid peroxidation", BIOCHEMICAL PHARMACOLOGY, ELSEVIER, US, vol. 54, no. 8, 1 October 1997 (1997-10-01), US , pages 871 - 876, XP055923185, ISSN: 0006-2952, DOI: 10.1016/S0006-2952(97)00254-2
TAMPO YOSHIKO, YONAHA MASANORI: "Enzymatic and Molecular Aspects of the Antioxidant Effect of Menadione in Hepatic Microsomes", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, ACADEMIC PRESS, US, vol. 334, no. 1, 1 October 1996 (1996-10-01), US , pages 163 - 174, XP055923187, ISSN: 0003-9861, DOI: 10.1006/abbi.1996.0442
DHARMARAJA ALLIMUTHU T., DASH TAPAN K., KONKIMALLA V. BADIREENATH, CHAKRAPANI HARINATH: "Synthesis, thiol-mediated reactive oxygen species generation profiles and anti-proliferative activities of 2,3-epoxy-1,4-naphthoquinones", MEDCHEMCOMM, ROYAL SOCIETY OF CHEMISTRY, UNITED KINGDOM, vol. 3, no. 2, 1 January 2012 (2012-01-01), United Kingdom , pages 219 - 224, XP055923191, ISSN: 2040-2503, DOI: 10.1039/C1MD00234A
CELL, vol. 149, no. 5, 25 May 2012 (2012-05-25), pages 1060 - 72
CELL, vol. 171, no. 2, 5 October 2017 (2017-10-05), pages 273 - 285
CELLS, vol. 10, no. 8, 21 August 2021 (2021-08-21), pages 2153
INT J MOL SCI., vol. 21, no. 19, 1 October 2020 (2020-10-01), pages 7279
EXP EYE RES, vol. 191, 7 January 2020 (2020-01-07), pages 107922
FREE RADIC BIOL MED., vol. 167, 17 March 2021 (2021-03-17), pages 94 - 108
NAT CHEM BIOL, vol. 12, 2016, pages 608 - 613
CELL, vol. 156, 2014, pages 317 - 331
BIOCHEM BIOPHYS RES COMMUN, vol. 499, 2018, pages 44 - 51
CELL DEATH DIFFER, vol. 23, 2016, pages 369 - 379
NATURE CHEMICAL BIOLOGY, vol. 12, 2016, pages 497 - 503
NATURE, vol. 569, 2019, pages 270 - 274
BIOORG MED CHEM LETT, vol. 22, 2012, pages 1822 - 1826
NAT CHEM BIOL, vol. 14, 2018, pages 507 - 515
CELL, vol. 149, 2012, pages 1060 - 1072
Attorney, Agent or Firm:
HIROTA, Masanori (JP)
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