Title:
FGF21 FORMULATIONS
Document Type and Number:
WIPO Patent Application WO/2020/010117
Kind Code:
A3
Abstract:
The present application provides pharmaceutical formulations comprising a FGF-21 polypeptide, e.g., a modified FGF-21 polypeptide such as PEG-FGF-21, and one or more stabilizers such as the chelator DPTA. The formulations can be can further stabilized by including a surfactant such as polysorbate 80 and/or adjusting the pH to about 7.1. Also provided are methods of manufacture, methods of treatment, and kits.
Inventors:
PALM THOMAS (US)
KHOSSRAVI MEHRNAZ (US)
PATKE SANKET (US)
KHOSSRAVI MEHRNAZ (US)
PATKE SANKET (US)
Application Number:
PCT/US2019/040356
Publication Date:
February 13, 2020
Filing Date:
July 02, 2019
Export Citation:
Assignee:
BRISTOL MYERS SQUIBB CO (US)
International Classes:
A61K9/00; A61K9/08; A61K38/18; A61K47/18; A61K47/26
Foreign References:
| US20130164310A1 | 2013-06-27 | |||
| US20130085098A1 | 2013-04-04 |
Attorney, Agent or Firm:
KIM, Ji Eun et al. (US)
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