FIBER-OPTIC ASSAY APPARATUS BASED ON PHASE-SHIFT INTERFEROMETRY

Title:

FIBER-OPTIC ASSAY APPARATUS BASED ON PHASE-SHIFT INTERFEROMETRY

Document Type and Number:

WIPO Patent Application WO2005047854

Kind Code:

A3

Abstract:

Apparatus and method for detecting the presence or amount or rate of binding of an analyte (46) in a sample solution is disclosed. The apparatus includes an optical assembly (26) having first (42) and second (40) reflecting surfaces separated by a distance "d" greater than 50 nm, where the first surface is formed by a layer of analyte-binding molecules (44), and a light source (22) for directing a beam of light onto said first and second reflecting surface. A detector (28) in the apparatus operates to detect a change in the thickness of the first reflecting layer resulting from binding of analyte to the analyte-binding molecules, when the assembly is placed in the solution of analyte, by detecting a shift in phase of light waves reflected from the first and second surfaces.

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Inventors:

TAN HONG (US)
TAN YUSHAN (CN)
CHEN DUAN JUN (US)
WITTE KRISTA LEAH (US)

Application Number:

PCT/US2004/036830

Publication Date:

December 15, 2005

Filing Date:

November 05, 2004

Export Citation:

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Assignee:

FORTEBIO INC (US)
TAN HONG (US)
TAN YUSHAN (CN)
CHEN DUAN JUN (US)
WITTE KRISTA LEAH (US)

International Classes:

G01N21/77; G01N33/543; (IPC1-7): G01B9/02

Foreign References:

US5804453A	1998-09-08
US20010048072A1	2001-12-06

Other References: