Title:
FIBRINOGEN RECEPTOR ANTAGONISTS AND THEIR USE
Document Type and Number:
WIPO Patent Application WO2005035495
Kind Code:
A3
Abstract:
This invention relates to novel fused bicyclic compounds of the general formula (I): wherein the symbols are defined herein, to pharmaceutical compositions containing the compounds, processes for preparing the compounds, and to methods of using the compounds, alone or in combination with other therapeutic agents. The compounds are antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex, and are therefore useful for the inhibition of platelet aggregation, and for the treatment of thrombotic diseases and other diseases.
Inventors:
LAL BANSI (IN)
GANGOPADHYAY ASHOK KUMAR (IN)
RAO VADLAMUDI V S V (IN)
GUPTE RAVINDRA DATTATRAYA (IN)
GOLE GOPAL VISHNU (IN)
KULKARNI-ALMEIDA ASHA (IN)
KRISHNAN SRIDEVI (IN)
PANICKER RADHA BHASKAR (IN)
PINTO DE SOUZA ELEANOR (IN)
GANGOPADHYAY ASHOK KUMAR (IN)
RAO VADLAMUDI V S V (IN)
GUPTE RAVINDRA DATTATRAYA (IN)
GOLE GOPAL VISHNU (IN)
KULKARNI-ALMEIDA ASHA (IN)
KRISHNAN SRIDEVI (IN)
PANICKER RADHA BHASKAR (IN)
PINTO DE SOUZA ELEANOR (IN)
Application Number:
PCT/IB2004/051922
Publication Date:
July 07, 2005
Filing Date:
September 30, 2004
Export Citation:
Assignee:
NICHOLAS PIRAMAL INDIA LTD (IN)
LAL BANSI (IN)
GANGOPADHYAY ASHOK KUMAR (IN)
RAO VADLAMUDI V S V (IN)
GUPTE RAVINDRA DATTATRAYA (IN)
GOLE GOPAL VISHNU (IN)
KULKARNI-ALMEIDA ASHA (IN)
KRISHNAN SRIDEVI (IN)
PANICKER RADHA BHASKAR (IN)
PINTO DE SOUZA ELEANOR (IN)
LAL BANSI (IN)
GANGOPADHYAY ASHOK KUMAR (IN)
RAO VADLAMUDI V S V (IN)
GUPTE RAVINDRA DATTATRAYA (IN)
GOLE GOPAL VISHNU (IN)
KULKARNI-ALMEIDA ASHA (IN)
KRISHNAN SRIDEVI (IN)
PANICKER RADHA BHASKAR (IN)
PINTO DE SOUZA ELEANOR (IN)
International Classes:
C07D209/46; C07D401/06; C07D413/04; (IPC1-7): A61K31/4035; A61P7/02; C07D209/46; C07D401/06; C07D413/04
Foreign References:
| EP0655439A2 | 1995-05-31 | |||
| EP1391451A1 | 2004-02-25 | |||
| EP0540334A1 | 1993-05-05 | |||
| US3997572A | 1976-12-14 | |||
| DD66175A | ||||
| GB989917A | 1965-04-22 |
Other References:
NEW J S ET AL: "Buspirone analogues. 2. Structure-activity relationships of aromatic imide derivatives", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 29, no. 8, 1986, pages 1476 - 1482, XP002939655, ISSN: 0022-2623
SUGIMOTO H ET AL: "Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-(2-phthalimidoethyl)piperidine and related derivatives", JOURNAL OF MEDICINAL CHEMISTRY., vol. 35, no. 24, 1992, USAMERICAN CHEMICAL SOCIETY. WASHINGTON., pages 4542 - 4548, XP002319779
SUGIMOTO H ET AL: "Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-(2-phthalimidoethyl)piperidine and related derivatives", JOURNAL OF MEDICINAL CHEMISTRY., vol. 35, no. 24, 1992, USAMERICAN CHEMICAL SOCIETY. WASHINGTON., pages 4542 - 4548, XP002319779
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