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Title:
FIBROBLAST GROWTH FACTOR RECEPTOR 3 (FGFR3) BINDING PROTEINS
Document Type and Number:
WIPO Patent Application WO/2010/002862
Kind Code:
A3
Abstract:
Monoclonal antibodies that bind and inhibit activation of fibroblast growth factor receptor 3 (FGFR3) are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of FGFR3.

Inventors:
WENG ZHIGANG (US)
WINSTON WILLIAM M JR (US)
BREAULT LYNE (US)
MEETZE KRISTAN (US)
WEILER SOLLY (US)
GYURIS JENO (US)
Application Number:
PCT/US2009/049211
Publication Date:
May 27, 2010
Filing Date:
June 30, 2009
Export Citation:
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Assignee:
AVEO PHARMACEUTICALS INC (US)
WENG ZHIGANG (US)
WINSTON WILLIAM M JR (US)
BREAULT LYNE (US)
MEETZE KRISTAN (US)
WEILER SOLLY (US)
GYURIS JENO (US)
International Classes:
C07H21/00; C07K16/28; C12P21/08
Domestic Patent References:
WO2008062063A12008-05-29
WO2008020586A12008-02-21
Foreign References:
US20070248605A12007-10-25
US20040005643A12004-01-08
US20060030015A12006-02-09
JP2004121026A2004-04-22
US20030152571A12003-08-14
US20060263369A12006-11-23
US20040044187A12004-03-04
US20070178095A12007-08-02
US20030211106A12003-11-13
US20040034888A12004-02-19
US20050208042A12005-09-22
US20030077793A12003-04-24
US20070025992A12007-02-01
US7288637B22007-10-30
US20020098189A12002-07-25
US20040038339A12004-02-26
US20080038257A12008-02-14
US7319139B22008-01-15
US20070059306A12007-03-15
US20010029293A12001-10-11
US20040052783A12004-03-18
Other References:
See also references of EP 2313435A4
Attorney, Agent or Firm:
STERN-DOMBAL, Charlene, A. et al. (Exchange PlaceBoston, MA, US)
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