Title:
FIBROBLAST HAVING ENHANCED ERYTHROPOIETIN PRODUCTION ABILITY
Document Type and Number:
WIPO Patent Application WO/2021/177387
Kind Code:
A1
Abstract:
By culturing a human fibroblast using a culture medium supplemented with TNF-α and IL-4, it is found that the EPO production ability in the fibroblast can be improved. As the result of the finding, a fibroblast having an enhanced EPO production ability is discovered, and a means for improving an EPO production-decreased state or a means for treating a renal disorder or renal anemia using the cell is also discovered.
Inventors:
IWAMIYA TAKAHIRO (JP)
Application Number:
PCT/JP2021/008325
Publication Date:
September 10, 2021
Filing Date:
March 04, 2021
Export Citation:
Assignee:
METCELA INC (JP)
International Classes:
C12N5/071; A61K35/33; A61K38/22; A61P7/06; A61P13/12
Domestic Patent References:
| WO2016006262A1 | 2016-01-14 | |||
| WO2018155651A1 | 2018-08-30 | |||
| WO2020045547A1 | 2020-03-05 | |||
| WO2016006262A1 | 2016-01-14 | |||
| WO2018155651A1 | 2018-08-30 |
Foreign References:
| JP2003174897A | 2003-06-24 | |||
| US20050064443A1 | 2005-03-24 |
Other References:
OKADA, N. ET AL.: "The Implications of the Upregulation of ICAM-1/ VCAM-1 Expression of Corneal fibroblasts on the Pathogenesis of Allergic Keratopathy", INVEST. OPHTHALOMOL. VIS. SCI., vol. 46, no. 12, 2005, pages 4512 - 4518, XP055696811, DOI: 10.1167/iovs.04-1494
NEPHRON, vol. 77, no. 2, 1997, pages 176 - 185
PROC NATL ACAD SCI., vol. 101, no. 41, 2004, pages 14907 - 14912
J RENAL INJ PREV, vol. 2, no. 1, 2013, pages 29 - 30
See also references of EP 4116412A4
NEPHRON, vol. 77, no. 2, 1997, pages 176 - 185
PROC NATL ACAD SCI., vol. 101, no. 41, 2004, pages 14907 - 14912
J RENAL INJ PREV, vol. 2, no. 1, 2013, pages 29 - 30
See also references of EP 4116412A4
Attorney, Agent or Firm:
IP FIRM SHUWA (JP)
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