Title:
FIBROBLAST THERAPY FOR INFLAMMATORY BOWEL DISEASE
Document Type and Number:
WIPO Patent Application WO/2021/097434
Kind Code:
A8
Abstract:
In some aspects, disclosed herein are methods and compositions for treatment of inflammatory bowel disease using fibroblasts or derivatives thereof. Disclosed herein are compositions having tolerogenic properties. Compositions of the present disclosure include fibroblasts, activated fibroblasts, fibroblast apoptotic bodies, and fibroblast exosomes. Methods of the present disclosure include, in some cases, providing fibroblasts or derivatives thereof to a subject to treat an inflammatory bowel disease. In some cases, dendritic cells are cultured with fibroblasts and provided to a subject to treat an inflammatory bowel disease.
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Inventors:
ICHIM THOMAS (US)
O'HEERON PETE (US)
O'HEERON PETE (US)
Application Number:
PCT/US2020/060748
Publication Date:
January 20, 2022
Filing Date:
November 16, 2020
Export Citation:
Assignee:
FIGENE LLC (US)
International Classes:
C07K14/50; A61K38/18
Attorney, Agent or Firm:
SISTRUNK, Melissa (US)
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