Title:
FIBROUS COMPOSITE FOR TISSUE ENGINEERING
Document Type and Number:
WIPO Patent Application WO2005007802
Kind Code:
A3
Abstract:
Provided are fibrous composites prepared by methods of the present invention, comprising oxides and biodegradable polymers, in which the fibers are made of aerogel-like oxide materials having nanometer-sized pores. The fibrous composition advantageously has, at least, the following characteristics: (i) a very high nanoporous surface area, which also permits nucleation of crystallites; (ii) mesoporous / macroporous interspacial networks between the fibers, providing high bioactivity and a high transport rate; (iii) macropores for natural bone-like tissue growth; (iv) good mechanical properties for handling and for implant support; and (v) biodegradability for implant dissolution and time-variable mechanical properties. Further provided are methods for using the bioactive biodegradable fibrous composites as osteogenic composite materials for tissue engineering, tissue re-growth, bone implants, and bone repair, and/or for the delivery of drugs or therapeutic compounds.
Inventors:
CHOI HOON (US)
CHEN I-WEI (US)
CHEN I-WEI (US)
Application Number:
PCT/US2003/008128
Publication Date:
May 19, 2005
Filing Date:
March 14, 2003
Export Citation:
Assignee:
UNIV PENNSYLVANIA (US)
CHOI HOON (US)
CHEN I-WEI (US)
CHOI HOON (US)
CHEN I-WEI (US)
International Classes:
A61F2/00; A61F2/02; A61K9/70; A61L27/18; A61L27/44; C12N; (IPC1-7): A61F2/02
Foreign References:
| US6261679B1 | 2001-07-17 |
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