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Title:
FIDAXOMICIN PURIFICATION METHOD
Document Type and Number:
WIPO Patent Application WO/2016/004848
Kind Code:
A1
Abstract:
A fidaxomicin purification method, comprising: fermenting Actinoplanes sp. HS-16-20 to generate fermented liquid; conducting solid/liquid separation on the fermented liquid, soaking mycelium in an organic solvent, and filtering to obtain a solution containing fidaxomicin; treating the solution with nanofiltration concentrate, and separating to obtain fidaxomicin crude product; conducting preparative column chromatography on the fidaxomicin crude product, eluting with an acid aqueous solution containing an organic solvent, and separating to obtain the refined fidaxomicin product.

Inventors:
REN HUIJUN (CN)
LI DAOCHAO (CN)
YING XUEXIAO (CN)
CHEN FENG (CN)
ZHENG LINGHUI (CN)
WANG LINGPING (CN)
BAI HUA (CN)
Application Number:
PCT/CN2015/083435
Publication Date:
January 14, 2016
Filing Date:
July 07, 2015
Export Citation:
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Assignee:
ZHEJIANG HISUN PHARM CO LTD (CN)
International Classes:
C07H17/08; C07H1/06; C12P19/62
Domestic Patent References:
WO2014023616A12014-02-13
Foreign References:
CN103320355A2013-09-25
CN103275152A2013-09-04
CN102993251A2013-03-27
CN104098637A2014-10-15
CN104513286A2015-04-15
CN104560766A2015-04-29
Other References:
TU CONGHUI ET AL.: "Separation mechanism of nanofiltration membranes and its application in purifying and separating pharmaceutical products.", PROCEEDINGS OF THE FOURTH NATIONAL PHARMACEUTICAL INDUSTRY SYMPOSIUM ON MEMBRANE SEPARATION TECHNOLOGY APPLICATIONS, 30 June 2007 (2007-06-30), pages 138 - 149, XP008185252
See also references of EP 3168225A4
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
上海弼兴律师事务所 (CN)
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