Title:
FIMBRIAE TYPE OF PORPHYROMONAS GULAE
Document Type and Number:
WIPO Patent Application WO/2013/089166
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a method for determining the pathogenic strength/weakness of bacteria transmitted in the case of canine periodontal disease. The inventors of the present invention have found that the main pathogen for canine periodontal disease is a bacteria called Porphyromonas gulae, and furthermore have revealed Fimbrillin which is the protein forming the fimbriae of this bacteria, and fimA gene, the gene coding FimA, can be mainly classified into three groups, and that there is a correlation in the relevance of each group to the virulence of the bacteria causing periodontal disease, and thus accomplished the present invention.
Inventors:
ASAI FUMITOSHI (JP)
KATO YUKIO (JP)
SHIRAI MITSUYUKI (JP)
MURAKAMI MASARU (JP)
NAKANO KAZUHIKO (JP)
NOMURA RYOTA (JP)
KATO YUKIO (JP)
SHIRAI MITSUYUKI (JP)
MURAKAMI MASARU (JP)
NAKANO KAZUHIKO (JP)
NOMURA RYOTA (JP)
Application Number:
PCT/JP2012/082288
Publication Date:
June 20, 2013
Filing Date:
December 13, 2012
Export Citation:
Assignee:
SCHOOL CORP AZABU VETERINARY MEDICINE EDUCATIONAL INSTITUTION (JP)
UNIV OSAKA (JP)
UNIV OSAKA (JP)
International Classes:
C12N15/09; A61K39/02; C07K16/12; C12Q1/68
Other References:
HAMADA, N. ET AL.: "Molecular and antigenic similarities of the fimbrial major components between Porphyromonas gulae and P. gingivalis.", VET. MICROBIOL., vol. 128, no. 1-2, 2008, pages 108 - 117
AMANO, A. ET AL.: "Variations of Porphyromonas gingivalis fimbriae in relation to microbial pathogenesis.", J. PERIODONTAL. RES., vol. 39, no. 2, 2004, pages 136 - 142
NOMURA, R. ET AL.: "Diversity of fimbrillin among Porphyromonas gulae clinical isolates from Japanese dogs.", J. VET. MED. SCI., vol. 74, no. 7, 2012, pages 885 - 891
YAMASAKI, Y. ET AL.: "Distribution and molecular characterization of Porphyromonas gulae carrying a new fimA genotype.", VET. MICROBIOL., vol. 161, no. 1-2, 28 December 2012 (2012-12-28), pages 196 - 205
AMANO, A. ET AL.: "Variations of Porphyromonas gingivalis fimbriae in relation to microbial pathogenesis.", J. PERIODONTAL. RES., vol. 39, no. 2, 2004, pages 136 - 142
NOMURA, R. ET AL.: "Diversity of fimbrillin among Porphyromonas gulae clinical isolates from Japanese dogs.", J. VET. MED. SCI., vol. 74, no. 7, 2012, pages 885 - 891
YAMASAKI, Y. ET AL.: "Distribution and molecular characterization of Porphyromonas gulae carrying a new fimA genotype.", VET. MICROBIOL., vol. 161, no. 1-2, 28 December 2012 (2012-12-28), pages 196 - 205
Attorney, Agent or Firm:
ONO, Shinjiro et al. (JP)
Ono Shinjiro (JP)
Ono Shinjiro (JP)
Download PDF:
Claims: