Title:
FINDING AND TREATMENT OF INFLAMMATION AFTER BIRTH IN CHIMERIC ANIMAL
Document Type and Number:
WIPO Patent Application WO/2018/139502
Kind Code:
A1
Abstract:
The inventor of the present invention found that chimeric animals suffer from noticeable inflammation, though neither immune response nor inflammation in the fetal period of these animals has been reported hitherto. This is an unexpected finding since chimeric animals in the fetal period were exclusively analyzed in prior studies and thus it is deemed that immunotolerance has been theoretically established therein. The present invention provides a composition for suppressing immune response or inflammation in the fetal period of a born chimeric animal.
Inventors:
NAKAUCHI HIROMITSU (JP)
YAMAGUCHI TOMOYUKI (JP)
HAMANAKA SANAE (JP)
SATO HIDEYUKI (JP)
MASAKI HIDEKI (JP)
MIZUNO NAOAKI (JP)
WATANABE MOTOO (JP)
YAMAGUCHI TOMOYUKI (JP)
HAMANAKA SANAE (JP)
SATO HIDEYUKI (JP)
MASAKI HIDEKI (JP)
MIZUNO NAOAKI (JP)
WATANABE MOTOO (JP)
Application Number:
PCT/JP2018/002178
Publication Date:
August 02, 2018
Filing Date:
January 25, 2018
Export Citation:
Assignee:
UNIV TOKYO (JP)
International Classes:
A61K45/00; A61K31/56; A61K31/573; A61P17/00; A61P29/00; A61P37/06; A61P43/00; C12N5/073; C12N5/16; C12N15/09
Other References:
KOBAYASHI T. ET AL.: "Generation of rat pancreas in mouse by interspecific blastocyst injection of pluripotent stem cells.", CELL, vol. 142, no. 5, 2010, pages 787 - 799, XP055053670, ISSN: 0092-8674
YAMAGUCHI T. ET AL.: "Interspecies organogenesis generates autologous functional islets.", NATURE, vol. 542, no. 7640, 9 February 2017 (2017-02-09), pages 191 - 196, XP055530982, ISSN: 0028-0836
OKADA: "Application of highly immunodeficient mice for biomedical research", CYTOMETRY RESEARCH, vol. 27, no. 1, 31 May 2017 (2017-05-31), pages 25 - 31, XP055530999, ISSN: 0916-6920
WALSH N. C. ET AL.: "Humanized Mouse Models of Clinical Disease.", ANNUAL REVIEW OF PATHOLOGY, vol. 12, 5 December 2016 (2016-12-05), pages 187 - 215, XP055519301, ISSN: 1553-4006, Retrieved from the Internet
RASHID T. ET AL.: "Revisiting the flight of Icarus: making human organs from PSCs with large animal chimeras.", CELL STEM CELL, vol. 15, no. 4, 2014, pages 406 - 409, XP055343901, ISSN: 1934-5909
CHEN J. ET AL.: "RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development.", PROC. NATL. ACAD. SCI. USA, vol. 90, no. 10, 1993, pages 4528 - 4532, XP055531002, ISSN: 0027-8424
WU J. ET AL.: "Interspecies Chimerism with Mammalian Pluripotent Stem Cells.", CELL, vol. 168, no. 3, 26 January 2017 (2017-01-26), pages 473 - 486, XP029897815, ISSN: 0092-8674
YAMAGUCHI T. ET AL.: "Interspecies organogenesis generates autologous functional islets.", NATURE, vol. 542, no. 7640, 9 February 2017 (2017-02-09), pages 191 - 196, XP055530982, ISSN: 0028-0836
OKADA: "Application of highly immunodeficient mice for biomedical research", CYTOMETRY RESEARCH, vol. 27, no. 1, 31 May 2017 (2017-05-31), pages 25 - 31, XP055530999, ISSN: 0916-6920
WALSH N. C. ET AL.: "Humanized Mouse Models of Clinical Disease.", ANNUAL REVIEW OF PATHOLOGY, vol. 12, 5 December 2016 (2016-12-05), pages 187 - 215, XP055519301, ISSN: 1553-4006, Retrieved from the Internet
RASHID T. ET AL.: "Revisiting the flight of Icarus: making human organs from PSCs with large animal chimeras.", CELL STEM CELL, vol. 15, no. 4, 2014, pages 406 - 409, XP055343901, ISSN: 1934-5909
CHEN J. ET AL.: "RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development.", PROC. NATL. ACAD. SCI. USA, vol. 90, no. 10, 1993, pages 4528 - 4532, XP055531002, ISSN: 0027-8424
WU J. ET AL.: "Interspecies Chimerism with Mammalian Pluripotent Stem Cells.", CELL, vol. 168, no. 3, 26 January 2017 (2017-01-26), pages 473 - 486, XP029897815, ISSN: 0092-8674
Attorney, Agent or Firm:
OHNO Seiji et al. (JP)
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