Title:
SUSTAINED−RELEASE FINE PARTICLE AND PROCESS FOR PRODUCING THE SAME
Document Type and Number:
WIPO Patent Application WO/2003/032998
Kind Code:
A1
Abstract:
Sustained−release fine particles containing theophylline which are suitable for use as a pharmaceutical preparation to be administered once a day. The sustained−release fine particles can be obtained by pulverizing a powder comprising theophylline, a wax, and a water−insoluble polymer and coating the fine particles with a water−insoluble polymer. Due to the use of a wax and a water−insoluble polymer in combination, the fine particles can release theophylline at a given rate over long. The particles showed a release rate pattern indicating that they can be administered once a day.
Inventors:
HIGO NOBUHIRO (JP)
NOMURA TATSUO (JP)
SHINKAI YASUNARI (JP)
NOMURA TATSUO (JP)
SHINKAI YASUNARI (JP)
Application Number:
PCT/JP2002/010643
Publication Date:
April 24, 2003
Filing Date:
October 15, 2002
Export Citation:
Assignee:
MITSUBISHI PHARMA CORP (JP)
HIGO NOBUHIRO (JP)
NOMURA TATSUO (JP)
SHINKAI YASUNARI (JP)
HIGO NOBUHIRO (JP)
NOMURA TATSUO (JP)
SHINKAI YASUNARI (JP)
International Classes:
A61K9/14; A61K31/522; (IPC1-7): A61K31/522; A61K9/14; A61K47/30; A61K47/44
Foreign References:
JPH0920686A | 1997-01-21 | |||
JP2001106627A | 2001-04-17 | |||
EP1025848A1 | 2000-08-09 | |||
US5162110A | 1992-11-10 | |||
US5413782A | 1995-05-09 | |||
EP0257310A1 | 1988-03-02 | |||
JP2002179571A | 2002-06-26 |
Attorney, Agent or Firm:
Takayanagi, Masau (Intellectual Property Department 2-6,
Nihonbashi-honcho 2-chom, Chuo-ku Tokyo, JP)
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