Title:
FIVE-MEMBERED HETEROCYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2010/117040
Kind Code:
A1
Abstract:
Disclosed is a compound having excellent FATP4 inhibitory activity. Specifically disclosed is a five-membered heterocyclic compound represented by formula (I) or a pharmaceutically acceptable salt thereof. In formula (I), A represents -CO- or -CH2-; X represents -CH2-, -O- or -NH-; Y and W may be the same or different and each represents formula (II) or formula (III); Ar represents formula (IV) or the like; and R1 represents -CO-NR6R7, -CO2-R8, -NHCO-R9 or the like.
More Like This:
Inventors:
TAGUCHI MINORU (JP)
BUSUJIMA TSUYOSHI (JP)
SUZUKI RYO (JP)
KOBASHI YOHEI (JP)
BOHNO MASAHIRO (JP)
YABUUCHI TETSUYA (JP)
HASHIMOTO YUKO (JP)
BUSUJIMA TSUYOSHI (JP)
SUZUKI RYO (JP)
KOBASHI YOHEI (JP)
BOHNO MASAHIRO (JP)
YABUUCHI TETSUYA (JP)
HASHIMOTO YUKO (JP)
Application Number:
PCT/JP2010/056379
Publication Date:
October 14, 2010
Filing Date:
April 08, 2010
Export Citation:
Assignee:
FUJIFILM CORP (JP)
TAISHO PHARMACEUTICAL CO LTD (JP)
TAGUCHI MINORU (JP)
BUSUJIMA TSUYOSHI (JP)
SUZUKI RYO (JP)
KOBASHI YOHEI (JP)
BOHNO MASAHIRO (JP)
YABUUCHI TETSUYA (JP)
HASHIMOTO YUKO (JP)
TAISHO PHARMACEUTICAL CO LTD (JP)
TAGUCHI MINORU (JP)
BUSUJIMA TSUYOSHI (JP)
SUZUKI RYO (JP)
KOBASHI YOHEI (JP)
BOHNO MASAHIRO (JP)
YABUUCHI TETSUYA (JP)
HASHIMOTO YUKO (JP)
International Classes:
A61K31/357; C07D207/277; A61K31/365; A61K31/381; A61K31/4015; A61K31/4025; A61K31/4152; A61K31/4166; A61K31/4178; A61K31/4196; A61K31/421; A61K31/4525; A61K31/4535; A61K31/454; A61K31/4545; A61K31/496; A61K31/551; A61P3/04; A61P3/06; A61P3/10; A61P7/00; A61P9/10; A61P9/12; A61P43/00; C07D231/08; C07D233/32; C07D249/12; C07D263/22; C07D307/30; C07D307/32; C07D317/36; C07D401/12; C07D405/08; C07D405/12; C07D405/14; C07D407/12; C07D409/04; C07D409/12; C07D409/14
Domestic Patent References:
| WO2008006187A2 | 2008-01-17 |
Foreign References:
| US20090163545A1 | 2009-06-25 | |||
| GB1278651A | 1972-06-21 | |||
| CN101284815A | 2008-10-15 | |||
| CN1807421A | 2006-07-26 | |||
| JP2006076963A | 2006-03-23 | |||
| JPS62180363A | 1987-08-07 | |||
| JPS5461936A | 1979-05-18 |
Other References:
BLACKBURN C., ET AL.: "Identification and characterization of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones as inhibitors of the fatty acid transporter FATP4", BIOORG.MED.CHEM.LETT., vol. 16, no. 13, 1 June 2006 (2006-06-01), pages 3504 - 3509
OLE WINKELMANN, CHRISTIAN NAETHER AND ULRICH LUENING: "Organocatalysis by bimacrocyclic NHCs: unexpected formation of a cyclic hemiacetal instead of a y-butyrolactone", ORG.BIOMOL.CHEM., vol. 7, no. 3, 2009, pages 553 - 556
JUSTIN R. STRUBLE, ET AL.: "Synthesis of an N-Mesityl Substituted Chiral Imidazolium Salt for NHC-Catalyzed Reactions", ORG.LETT., vol. 10, no. 5, 2008, pages 957 - 960
WOLFGANG SCHRADER, ET AL.: "Investigating organocatalytic reactions: mass spectrometric studies of a conjugate umpolung reaction", CHEMICAL COMMUNICATIONS, no. 7, 2007, pages 716 - 718
CHRISTIAN BURSTEIN, FRANK GLORIUS DR: "Organocatalyzed Conjugate Umpolung of, beta-Unsaturated Aldehydes for the Synthesis of -Butyrolactones", ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 43, no. 45, 17 November 2004 (2004-11-17), pages 6205 - 6208
STEPHANIE S. SOHN, EVELYN L. ROSEN, AND JEFFREY W. BODE: "N-Heterocyclic Carbene-Catalyzed Generation of Homoenolates: y-Butyrolactones by Direct Annulations of Enals and Aldehydes", J.AM.CHEM.SOC., vol. 126, no. 44, 2004, pages 14370 - 14371
ALAN R. KATRITZKY, DAMING FENG, AND HENGYUAN LANG: "Benzotriazole- and 1,2,4-Triazole-Stabilized Allylic Anions: Applications in Syntheses of Functionalized alpha,beta-Unsaturated Ketones, y-Lactones, y-Lactams, and beta-Substituted Esters", J.ORG.CHEM., vol. 62, no. 3, 1997, pages 706 - 714
MAKOTO HOJO, NARUYASU ISHIBASHI, AKIRA HOSOMI: "Versatile Reactivities of Carbonyl Ylids toward Unactivated Alkenes and Heterodipolarophiles, and their Synthetic Use1", SYNLETT, 1996, pages 234 - 236
CHIH JUNG CHANG, JIM MIN FANG, LI FAN LIAO: "Regio-, stereo-, and enantioselectivity in the electrophilic reactions of 2-amino-4-phenyl-3-butenenitriles", J.ORG.CHEM., vol. 58, no. 7, 1993, pages 1754 - 1761
SIU LING B. WANG, ET AL.: "Carbon-hydrogen insertions in the reactions of Fischer carbene complexes with ketene acetals", J.AM.CHEM.SOC., vol. 114, no. 26, 1992, pages 10665 - 10666
CHEMICAL ABSTRACTS, vol. 67, Columbus, Ohio, US; abstract no. 10083B
CHEMICAL ABSTRACTS, vol. 52, Columbus, Ohio, US; abstract no. 77220
JIA H.-S., ET AL.: "1-(4-Isopropylphenyl)-5-(4-methoxyphenyl)pyrazolidin-3-one", ACTA CRYSTALLOGRAPHICA SEC.E, vol. E64, no. 5, 16 April 2008 (2008-04-16), pages O855
SUN Y.-F., ET AL.: "5-(3,4-Dimethoxyphenyl)-1-(4-methylphenyl)pyrazolidin-3-one", ACTA CRYSTALLOGRAPHICA SEC.E, vol. E63, no. 8, 2007, pages O3657
ZHIFANG LI, YONGMIN ZHANG: "Novel cyclization of dimeric dianions of anils or aldehydes with triphosgene: A safe and efficient synthesis of substituted imidazolidin-2-ones and 4,5-diaryl-1,3-dioxolan-2-ones", HETEROATOM CHEMISTRY, vol. 14, no. 1, 24 January 2003 (2003-01-24), pages 46 - 49
STEFANO SUPERCHI, ET AL.: "Induction of Cholesteric Mesophases by Simple Cyclic Derivatives of p,p'-Disubstituted 1,2-Diphenylethane-1,2-diols: Importance of Shape and Polarizability Effects", J.ORG.CHEM., vol. 64, no. 13, 1999, pages 4762 - 4767
TIMOTHY W. WALLACE, ET AL.: "Heterodiene cycloadditions of C2 symmetric 4,5-disubstituted ketene acetals: the nett asymmetric conjugate addition of recyclable acetic ester enolate equivalents to an activated enone", J.CHEM.SOC., PERKIN TRANS. 1, no. 18, 1995, pages 2293 - 308
OLE WINKELMANN, CHRISTIAN NAETHER AND ULRICH LUENING: "Organocatalysis by bimacrocyclic NHCs: unexpected formation of a cyclic hemiacetal instead of a y-butyrolactone", ORG.BIOMOL.CHEM., vol. 7, no. 3, 2009, pages 553 - 556
JUSTIN R. STRUBLE, ET AL.: "Synthesis of an N-Mesityl Substituted Chiral Imidazolium Salt for NHC-Catalyzed Reactions", ORG.LETT., vol. 10, no. 5, 2008, pages 957 - 960
WOLFGANG SCHRADER, ET AL.: "Investigating organocatalytic reactions: mass spectrometric studies of a conjugate umpolung reaction", CHEMICAL COMMUNICATIONS, no. 7, 2007, pages 716 - 718
CHRISTIAN BURSTEIN, FRANK GLORIUS DR: "Organocatalyzed Conjugate Umpolung of, beta-Unsaturated Aldehydes for the Synthesis of -Butyrolactones", ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 43, no. 45, 17 November 2004 (2004-11-17), pages 6205 - 6208
STEPHANIE S. SOHN, EVELYN L. ROSEN, AND JEFFREY W. BODE: "N-Heterocyclic Carbene-Catalyzed Generation of Homoenolates: y-Butyrolactones by Direct Annulations of Enals and Aldehydes", J.AM.CHEM.SOC., vol. 126, no. 44, 2004, pages 14370 - 14371
ALAN R. KATRITZKY, DAMING FENG, AND HENGYUAN LANG: "Benzotriazole- and 1,2,4-Triazole-Stabilized Allylic Anions: Applications in Syntheses of Functionalized alpha,beta-Unsaturated Ketones, y-Lactones, y-Lactams, and beta-Substituted Esters", J.ORG.CHEM., vol. 62, no. 3, 1997, pages 706 - 714
MAKOTO HOJO, NARUYASU ISHIBASHI, AKIRA HOSOMI: "Versatile Reactivities of Carbonyl Ylids toward Unactivated Alkenes and Heterodipolarophiles, and their Synthetic Use1", SYNLETT, 1996, pages 234 - 236
CHIH JUNG CHANG, JIM MIN FANG, LI FAN LIAO: "Regio-, stereo-, and enantioselectivity in the electrophilic reactions of 2-amino-4-phenyl-3-butenenitriles", J.ORG.CHEM., vol. 58, no. 7, 1993, pages 1754 - 1761
SIU LING B. WANG, ET AL.: "Carbon-hydrogen insertions in the reactions of Fischer carbene complexes with ketene acetals", J.AM.CHEM.SOC., vol. 114, no. 26, 1992, pages 10665 - 10666
CHEMICAL ABSTRACTS, vol. 67, Columbus, Ohio, US; abstract no. 10083B
CHEMICAL ABSTRACTS, vol. 52, Columbus, Ohio, US; abstract no. 77220
JIA H.-S., ET AL.: "1-(4-Isopropylphenyl)-5-(4-methoxyphenyl)pyrazolidin-3-one", ACTA CRYSTALLOGRAPHICA SEC.E, vol. E64, no. 5, 16 April 2008 (2008-04-16), pages O855
SUN Y.-F., ET AL.: "5-(3,4-Dimethoxyphenyl)-1-(4-methylphenyl)pyrazolidin-3-one", ACTA CRYSTALLOGRAPHICA SEC.E, vol. E63, no. 8, 2007, pages O3657
ZHIFANG LI, YONGMIN ZHANG: "Novel cyclization of dimeric dianions of anils or aldehydes with triphosgene: A safe and efficient synthesis of substituted imidazolidin-2-ones and 4,5-diaryl-1,3-dioxolan-2-ones", HETEROATOM CHEMISTRY, vol. 14, no. 1, 24 January 2003 (2003-01-24), pages 46 - 49
STEFANO SUPERCHI, ET AL.: "Induction of Cholesteric Mesophases by Simple Cyclic Derivatives of p,p'-Disubstituted 1,2-Diphenylethane-1,2-diols: Importance of Shape and Polarizability Effects", J.ORG.CHEM., vol. 64, no. 13, 1999, pages 4762 - 4767
TIMOTHY W. WALLACE, ET AL.: "Heterodiene cycloadditions of C2 symmetric 4,5-disubstituted ketene acetals: the nett asymmetric conjugate addition of recyclable acetic ester enolate equivalents to an activated enone", J.CHEM.SOC., PERKIN TRANS. 1, no. 18, 1995, pages 2293 - 308
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
Kobayashi 浩 (JP)
Kobayashi 浩 (JP)
Download PDF:
Previous Patent: BENDING DEVICE
Next Patent: ELECTRIC WIRE TERMINAL TREATMENT DEVICE AND ELECTRIC WIRE TERMINAL TREATMENT METHOD
Next Patent: ELECTRIC WIRE TERMINAL TREATMENT DEVICE AND ELECTRIC WIRE TERMINAL TREATMENT METHOD