Title:
FIVE-MEMBERED NITROGEN-CONTAINING HETEROCYCLIC AND HETEROARYL DERIVATIVE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/020604
Kind Code:
A1
Abstract:
A five-membered nitrogen-containing heterocyclic and heteroaryl derivative as shown in general formula (I), a preparation method therefor, a pharmaceutical composition containing the derivative, and a use thereof as a therapeutic agent, and in particular a use thereof as an ATR kinase inhibitor and a use in preparation of a drug for preventing an ATR kinase-mediated disease.
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Inventors:
LI SHANG (CN)
HOU SHAOHUA (CN)
HOU SHAOHUA (CN)
Application Number:
PCT/CN2022/113490
Publication Date:
February 23, 2023
Filing Date:
August 19, 2022
Export Citation:
Assignee:
NANJING DAMEI BIOPHARMACEUTICAL CO LTD (CN)
International Classes:
C07D495/04; A61K31/5377; A61P35/00; C07D401/14; C07D403/04; C07D403/14; C07D487/04; C07D491/147
Domestic Patent References:
| WO2011005119A1 | 2011-01-13 | |||
| WO2010022358A1 | 2010-02-25 | |||
| WO2009120094A2 | 2009-10-01 |
Foreign References:
| CN112920199A | 2021-06-08 | |||
| US20120178737A1 | 2012-07-12 | |||
| CN102459272A | 2012-05-16 | |||
| CN102209714A | 2011-10-05 | |||
| JPH06220059A | 1994-08-09 | |||
| US20120202805A1 | 2012-08-09 |
Other References:
GAMAGE SWARNA A., GIDDENS ANNA C., TSANG KIT Y., FLANAGAN JACK U., KENDALL JACKIE D., LEE WOO-JEONG, BAGULEY BRUCE C., BUCHANAN CH: "Synthesis and biological evaluation of sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 25, no. 20, 15 October 2017 (2017-10-15), AMSTERDAM, NL, pages 5859 - 5874, XP093036389, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2017.09.025
SAFINA BRIAN S.; SWEENEY ZACHARY K.; LI JUN; CHAN BRYAN K.; BISCONTE ANGELINA; CARRERA DIANE; CASTANEDO GEORGETTE; FLAGELLA MICHAE: "Identification of GNE-293, a potent and selective PI3Kδ inhibitor: Navigating in vitro genotoxicity while improving potency and selecti", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 23, no. 17, 29 June 2013 (2013-06-29), Amsterdam NL , pages 4953 - 4959, XP028690067, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2013.06.052
CARRERA DIANE E., SHENG PEIJUE, SAFINA BRIAN S., LI JUN, ANGELAUD REMY: "Development of a Scalable Strategy for the Synthesis of PI3Kδ Inhibitors: Selective and Efficient Functionalization of Purine Derivatives", ORGANIC PROCESS RESEARCH & DEVELOPMENT, AMERICAN CHEMICAL SOCIETY, US, vol. 17, no. 1, 18 January 2013 (2013-01-18), US , pages 138 - 144, XP093036391, ISSN: 1083-6160, DOI: 10.1021/op300235t
DATABASE REGISTRY STN; ANONYMOUS : "9H-Purine, 2-(2-ethyl-1H-benzimidazol-1-yl)-9-methyl-6-(4-morpholinyl)-8- (4-piperidinyl)-", XP093036395
SAFINA BRIAN S.; SWEENEY ZACHARY K.; LI JUN; CHAN BRYAN K.; BISCONTE ANGELINA; CARRERA DIANE; CASTANEDO GEORGETTE; FLAGELLA MICHAE: "Identification of GNE-293, a potent and selective PI3Kδ inhibitor: Navigating in vitro genotoxicity while improving potency and selecti", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 23, no. 17, 29 June 2013 (2013-06-29), Amsterdam NL , pages 4953 - 4959, XP028690067, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2013.06.052
CARRERA DIANE E., SHENG PEIJUE, SAFINA BRIAN S., LI JUN, ANGELAUD REMY: "Development of a Scalable Strategy for the Synthesis of PI3Kδ Inhibitors: Selective and Efficient Functionalization of Purine Derivatives", ORGANIC PROCESS RESEARCH & DEVELOPMENT, AMERICAN CHEMICAL SOCIETY, US, vol. 17, no. 1, 18 January 2013 (2013-01-18), US , pages 138 - 144, XP093036391, ISSN: 1083-6160, DOI: 10.1021/op300235t
DATABASE REGISTRY STN; ANONYMOUS : "9H-Purine, 2-(2-ethyl-1H-benzimidazol-1-yl)-9-methyl-6-(4-morpholinyl)-8- (4-piperidinyl)-", XP093036395
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