FK506-BINDING PROTEIN GENE - OTSUKA PHARMA CO LTD

Title:

FK506-BINDING PROTEIN GENE

Document Type and Number:

WIPO Patent Application WO/1995/024480

Kind Code:

A1

Abstract:

An FK506-binding protein gene containing a base sequence coding for the amino acid sequence represented by SEQ ID NO:1; specifically an FK506-binding protein gene containing the base sequence represented by SEQ ID NO:2; a process for producing a recombinant FK506-binding protein by the expression of the above gene; and the recombinant FK506-binding protein thus produced. The gene can express an FK506-binding protein, and the obtained protein is useful especially for elucidating the mode of action of immunosuppression in vivo and developing and screening remedies for autoimmune diseases such as rheumatism and SLE.

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Inventors:

SHIN SADAHITO DI
FIJIWARA TSUTOMU (JP)
OKUNO SHIRO (JP)
HIRANO HISANOBU (JP)

Application Number:

PCT/JP1995/000393

Publication Date:

September 14, 1995

Filing Date:

March 09, 1995

Export Citation:

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Assignee:

OTSUKA PHARMA CO LTD (JP)
KIM SADAE & HF (JP)
SHIN KENKOO & HM (JP)
SHIN JUNNA & HM (JP)
FIJIWARA TSUTOMU (JP)
OKUNO SHIRO (JP)
HIRANO HISANOBU (JP)

International Classes:

C07K14/47; C12N9/90; C12N15/12; C12N15/09; C12N15/61; C12P21/02; C12R1/19; C12R1/91; (IPC1-7): C12N15/12; C07K14/47; C12P21/02

Foreign References:

JPH0654689A	1994-03-01
JPH0471492A	1992-03-06

Other References:

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol. 200, No. 2, 29-4-1994, HIROFUMI ARAKAWA et al., "Molecular Cloning and Expression of a Novel Human Gene that is Highly Homologous to Human FK506-Binding Protein 12KDa (hFKBP-12) and Characterization of Two Alternatively Spliced Transcripts", pages 836-843.
PROC. NATL. ACAD. SCI. U.S.A., Vol. 87, July 1990, NOBORU MAKI et al., "Complementary DNA Encoding the Human T-Cell FK506-Binding Protein, a Peptidylprolyl Cis-Trans Isomerase Distinct from Cyclophilin", pages 5440-5443.

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