HETEROAROMATIC DEAZA SPERMIDINE ANALOGUES AND THEIR USE TREATING CANCER FIELD OF THE INVENTION The invention relates to compounds, pharmaceutical compositions comprising the same, and methods of treatment employing the same. In particular, the compounds are useful for the treatment or prevention of cancer. BACKGROUND Dual-targeting or multi-targeting of malignant pathways by a single drug molecule represents an efficient, logical and alternative approach to drug combinations. A new generation of dual or multi-targeting drugs is emerging, where a single chemical entity can act on multiple molecular targets [Raghavendra NM, et al. Dual or multi-targeting inhibitors: The next generation anticancer agents. Eur J Med Chem.2018 Jan 1;143:1277-1300]. The present invention uses a rational, bioinformatics and poly- pharmacological approach to design multi-target anticancer agents by combining flavonoid-like structures with a variety of polyamine chains from the spermidine class. Both broad molecule structures have been shown to target multiple cellular pathways leading to cancer inhibition [Kikuchi H, Yuan B, Hu X, Okazaki M. Chemopreventive and anticancer activity of flavonoids and its possibility for clinical use by combining with conventional chemotherapeutic agents. Am J Cancer Res.2019;9(8):1517-1535; Carl W. Porter, Raymond J. Bergeron and Neal J. Stolowich. Biological Properties of N ⁴ -Spermidine Derivatives and Their Potential in Anticancer Chemotherapy. Cancer Res.1982 (42) (10) 4072-4078]. The role of flavonoids as potential cancer therapies includes the inhibition of activation of pro-carcinogens, inhibition of proliferation of cancer cells, selective death of cancer cells by apoptosis, inhibition of metastasis and angiogenesis, activation of immune response against cancer cells, modulation of the inflammatory cascade and the modulation of drug resistance [Kikuchi H, Yuan B, Hu X, Okazaki M. Chemopreventive and anticancer activity of flavonoids and its possibility for clinical use by combining with conventional chemotherapeutic agents. Am J Cancer Res.2019;9(8):1517-1535]. In spite of their promising potential in controlling the malignant process, natural flavonoids present major limitations to their clinical use due to low bioavailability and their perceived lack of specificity. Such versatile biological activity implies a great underlying complexity in the true mechanisms of action of different flavonoids, often dependent on a fine balance between pro- and anti-oxidant properties or between other beneficial and detrimental effects [Martinez Perez, et al.2014. Novel flavonoids as anti- cancer agents: mechanisms of action and promise for their potential application in breast cancer. Biochemical Society Transactions, vol.42, no.4, pp.1017 - 1023.]. As such, a systematic study of the structure activity relationship of the flavonoid structures is necessary and can be addressed by the rationale design of a series of molecules. The present invention addresses some of the limitations of flavonoid derivatives by employing a novel approach of combining such moieties with a synthetic polyamine chain with multiple potential advantages: (i) multi-targeting cancer pathways (ii) inhibition of the natural polyamine pathway which is often dysregulated in cancer and (iii) facilitating transport through the cell membrane and targeting to specific intracellular structures. It is well-known that polyamines interact with aspartate, glutamate, and aromatic residues of a given receptor and/or enzyme mainly through the formation of ion bonds, since at physiological pH, protonation of amino groups is nearly complete. From this, the hypothesis arises that a polyamine may be a universal template able to recognize different receptor systems. This hypothesis suggests that both affinity and selectivity may be fine-tuned by inserting appropriate substituents onto the amine functions and by varying the methylene chain lengths between them on the polyamine backbone [Minarini, A., Milelli, A., Tumiatti, V. et al. Synthetic polyamines: an overview of their multiple biological activities. Amino Acids 38, 383–392 (2010).] Polyamine metabolism is often dysregulated in cancers. In addition, the polyamine pathway is a downstream target for many oncogenes [Shantz LM, Levin VA. Regulation of ornithine decarboxylase during oncogenic transformation: mechanisms and therapeutic potential. Amino Acids.2007;33(2):213–23]. Polyamine biosynthesis is activated in tumors, and these metabolites are important for developmental and compensatory growth in response to systemic stimuli like hormones (growth hormones, corticosteroids, androgens, and estrogens). As a result, various strategies targeting polyamine biosynthetic enzymes have been brought to the preclinical and clinical arena [Arruabarrena-Aristorena A, et al. Oil for the cancer engine: The cross- talk between oncogenic signaling and polyamine metabolism. Sci Adv.2018;4(1):1-11]. The most successful and widely used inhibitor of polyamine biosynthesis is 2- difluoromethylornithine (DFMO). DFMO was specifically designed to be an enzyme- activated irreversible inhibitor of ODC [Metcalf BW, et al. Catalytic irreversible inhibition of mammalian ornithine decarboxylase (E.C4.1.1.17) by substrate and product analogues. J. Am. Chem. Soc.1978;100:2551–2553.] These encouraging results in selective cancers, both in vitro and in vivo led to clinical trials with DFMO as a single agent. Although DFMO was exceedingly well tolerated, there were no significant clinical responses observed in the early trials. More recently, a resurgence of interest in DFMO as a single agent has occurred in the treatment of neuroblastoma [Bassiri H, et al. Translational development of difluoromethylornithine (DFMO) for the treatment of neuroblastoma. Transl. Pediatr.2015;4:226–238] and as a chemoprevention agent, alone or in various combinations [Gerner EW, Meyskens FL Jr. Polyamines and cancer: old molecules, new understanding. Nat Rev Cancer.2004 Oct;4(10):781-92]. Another rational for linking polyamines to bioactive moieties is not only to use the polyamine transport system to enter the cell, but also to direct the agent to its intracellular molecular target, which can be mitochondria or other anionic structures [Murray-Stewart TR, et al. Targeting polyamine metabolism for cancer therapy and prevention. Biochem J.2016;473(19):2937-2953]. SUMMARY OF THE INVENTION A first aspect of the invention provides a compound of formula (1): Formula (1) wherein: Z is selected from: –NR ¹¹ R ¹² ; –N(R ¹⁰ )-(CH ₂ ) _p –NR ¹¹ R ¹² ; and –N(R ¹⁰ )-(CH2)q–N(R ¹⁰ )-(CH2)q–NR ¹¹ R ¹² ; 3 R ¹ , R ² , and R ⁴ independently, are selected from –OH, -O-C _1-4 alkyl, -OC(O)R ₁₃ , -OC(O)NHR ¹³ , –OC(O)N(R ¹³ )2; or R ¹ and R ² together form –O-CH2-O-; R ³ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ , independently, are selected from H; halo; -CN; -NO2; -R ^β ; -OH, -OR ^β ; -SH; -SR ^β ; -SOR ^β ; -SO ₂ H; -SO ₂ R ^β ; -SO ₂ NH ₂ ; -SO ₂ NHR ^β ; -SO ₂ N(R ^β ) ₂ ; -NH ₂ ; -NHR ^β ; -N(R ^β ) ₂ ; -CHO; -COR ^β ; -COOH; -COOR ^β ; -OCOR ^β ; and benzyl optionally substituted with 1-3 -R ^β ; each -R ^β is independently selected from a C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl , -O(C _1-2 alkyl) or C ₃ -C ₁₄ cyclic group, and wherein any -R ^β may optionally be substituted with one or more C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₃ -C ₇ cycloalkyl, -O(C ₁ -C ₄ alkyl), -O(C1-C4 haloalkyl), -O(C3-C7 cycloalkyl), halo, -OH, -NH2, -CN, -NO2, -C≡CH, - CHO, -CON(CH3)2 or oxo (=O) groups; each R ¹⁰ is independently selected from H, C1-6 alkyl, C2-C6 alkenyl, C2-6 alkynyl, C _3-10 cycloalkyl, and benzyl, wherein each R ¹⁰ , when not H, is independently optionally substituted with 1 or 2 -R ^β ; R ¹¹ and R ¹² are independently selected from H, C1-6-alkyl, C2-C6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, and benzyl, wherein each R ¹¹ and R ¹² , when is not H, are independently optionally substituted with 1 or 2 -R ^β ; or R ¹¹ and R ¹² together form a 5- or 6-membered heterocycle optionally having an additional heteroatom selected from N and O; wherein the 5- or 6-membered heterocycle is optionally substituted with 1 or 2 C1-4 alkyl, or benzyl; each -R ¹³ is independently selected from a H, C ₁ -C ₆ alkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, C _3-14 cyclic group, halo, -NO ₂ , -CN, -OH, -NH ₂ , mercapto, formyl, carboxy, carbamoyl, C1-6 alkoxy, C1-6 alkylthio, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, C1-6 alkylsulfinyl, C1-6 alkylsulfonyl, or arylsulfonyl, wherein any -R ¹³ may optionally be substituted with one or more –R ¹⁴ ; each R ¹⁴ is independently selected from a C ₁ -C ₆ alkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, C3-14 cyclic group, halo, -NO2, -CN, -OH, -NH2, mercapto, formyl, carboxy, carbamoyl, C1-6 alkoxy, C1-6 alkylthio, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, C1-6 alkylsulfinyl, C _1-6 alkylsulfonyl, or arylsulfonyl, wherein any –R ₁₄ may optionally be substituted with one or more –R ₁₅ ; each –R ¹⁵ is independently selected from halogen, nitro, cyano, hydroxy, trifluoromethoxy, trifluoromethyl, amino, formyl, carboxy, carbamoyl, mercapto, sulfamoyl, methyl, ethyl, methoxy, ethoxy, acetyl, acetoxy, methylamino, ethylamino, dimethylamino, diethylamino, N-methyl-N-ethylamino, acetylamino, N- methylcarbamoyl N-ethylcarbamoyl N,N-dimethylcarbamoyl, N,N-diethylcarbamoyl, N-methyl-N-ethylcarbamoyl, methylthio, ethylthio, methylsulfinyl, ethylsulfinyl, mesyl ethylsulfonyl, methoxycarbonyl, ethoxycarbonyl, N-methylsulfamoyl N-ethylsulfamoyl N,N-dimethylsulfamoyl N,N-diethylsulfamoyl, N-methyl-N-ethylsulfamoyl, carbocyclyl, aryl, or heterocyclyl; n = 1-6; each p is independently an integer selected from 1 to 4; and each q is independently an integer selected from 1 to 4. In one embodiment, the compound may be a compound of Formula (1A): wherein R ¹ , R ² , R ⁴ , R ⁶ , n and Z are as defined herein. A second aspect of the invention provides a compound selected from the group of compounds listed Table A. A third aspect of the invention provides pharmaceutically acceptable salt, multi-salt, solvate or prodrug of the compound of the first or second aspect of the invention. A fourth aspect of the invention provides a pharmaceutical composition comprising a compound of the first or second aspect of the invention, or a pharmaceutically acceptable multi-salt, solvate or prodrug of the third aspect of the invention, and a pharmaceutically acceptable excipient. A fifth aspect of the invention provides a compound of the first or second aspect of the invention, or a pharmaceutically acceptable multi-salt, solvate or prodrug of the third aspect of the invention, or a pharmaceutical composition of the fourth aspect of the invention, for use in medicine, and/or for use in the treatment or prevention of a disease, disorder or condition. In one embodiment, the disease, disorder or condition is cancer. A sixth aspect of the invention provides the use of a compound of the first or second aspect, a pharmaceutically effective multi-salt, solvate or prodrug of the third aspect, or a pharmaceutical composition according to the fourth aspect, in the manufacture of a medicament for the treatment or prevention of a disease, disorder or condition. Typically the treatment or prevention comprises the administration of the compound, multi-salt, solvate, prodrug or pharmaceutical composition to a subject. In one embodiment, the disease, disorder or condition is cancer. A seventh aspect of the invention provides a method of treatment or prevention of a disease, disorder or condition, the method comprising the step of administering an effective amount of a compound of the first or second aspect, or a pharmaceutically acceptable multi-salt, solvate or prodrug of the third aspect, or a pharmaceutical composition of the fourth aspect, to thereby treat or prevent the disease, disorder or condition. Typically the administration is to a subject in need thereof. In one embodiment, the disease, disorder or condition is cancer. Definitions In the context of the present specification, a “hydrocarbyl” substituent group or a hydrocarbyl moiety in a substituent group only includes carbon and hydrogen atoms but, unless stated otherwise, does not include any heteroatoms, such as N, O or S, in its carbon skeleton. A hydrocarbyl group/moiety may be saturated or unsaturated (including aromatic), and may be straight-chained or branched, or be or include cyclic groups wherein, unless stated otherwise, the cyclic group does not include any heteroatoms, such as N, O or S, in its carbon skeleton. Examples of hydrocarbyl groups include alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl and aryl groups/moieties and combinations of all of these groups/moieties. Typically a hydrocarbyl group is a C ₁ -C ₁₂ hydrocarbyl group. More typically a hydrocarbyl group is a C1-C10 hydrocarbyl group. A “hydrocarbylene” group is similarly defined as a divalent hydrocarbyl group. An “alkyl” substituent group or an alkyl moiety in a substituent group may be linear or branched. Examples of alkyl groups/moieties include methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, t-butyl and n-pentyl groups/moieties. Unless stated otherwise, the term “alkyl” does not include “cycloalkyl”. Typically an alkyl group is a C ₁ -C ₁₂ alkyl group. More typically an alkyl group is a C ₁ -C ₆ alkyl group. An “alkylene” group is similarly defined as a divalent alkyl group. An “alkenyl” substituent group or an alkenyl moiety in a substituent group refers to an unsaturated alkyl group or moiety having one or more carbon-carbon double bonds. Examples of alkenyl groups/moieties include ethenyl, propenyl, 1-butenyl, 2-butenyl, 1- pentenyl, 1-hexenyl, 1,3-butadienyl, 1,3-pentadienyl, 1,4-pentadienyl and 1,4- hexadienyl groups/moieties. Unless stated otherwise, the term “alkenyl” does not include “cycloalkenyl”. Typically an alkenyl group is a C ₂ -C ₁₂ alkenyl group. More typically an alkenyl group is a C2-C6 alkenyl group. An “alkenylene” group is similarly defined as a divalent alkenyl group. An “alkynyl” substituent group or an alkynyl moiety in a substituent group refers to an unsaturated alkyl group or moiety having one or more carbon-carbon triple bonds. Examples of alkynyl groups/moieties include ethynyl, propargyl, but-1-ynyl and but-2- ynyl. Typically an alkynyl group is a C ₂ -C ₁₂ alkynyl group. More typically an alkynyl group is a C ₂ -C ₆ alkynyl group. An “alkynylene” group is similarly defined as a divalent alkynyl group. A “haloalkyl” substituent group or haloalkyl group in a substituent group refers to an alkyl, alkenyl, or alkynyl substituent group or moiety including one or more carbon atoms and one or more halo atoms, e.g. Cl, Br, I, or F. Each halo atom replaces a hydrogen of the alkyl, alkenyl, or alkynyl substituent group or moiety. Examples include -CH ₂ F -CHF ₂ , -CHI ₂ , -CHBr ₂ ,-CHCl ₂ ,-CF ₃ , -CH ₂ CF ₃ and CF ₂ CH ₃ . An “alkoxy” substituent group or alkoxy group in a substituent group refers to an alkyl, alkenyl, or alkynyl substituent group or moiety including one or more carbon atoms and one or more oxygen atoms. Each oxygen atom replaces a carbon atom (for example the terminal or bonding carbon) of the alkyl, alkenyl, or alkynyl substituent group or moiety. Examples include -OCH3, -OCH2CH3, -OCH2CH2CH3, and -OCH(CH3)(CH3). An “alkylthio” substituent group or alkylthio group in a substituent group refers to an alkyl, alkenyl, or alkynyl substituent group or moiety including one or more carbon atoms and one or more sulphur atoms. Each sulphur atom replaces a carbon atom (for example the terminal or bonding carbon) of the alkyl, alkenyl, or alkynyl substituent group or moiety. Examples include -SCH ₃ , -SCH ₂ CH ₃ , -SCH ₂ CH ₂ CH ₃ , and - SCH(CH3)(CH3). An “alkylsulfinyl” substituent group or alkylsulfinyl group in a substituent group refers to an alkyl, alkenyl, or alkynyl substituent group or moiety including one or more carbon atoms and one or more sulfinyl groups (-S(=O)-). Each sulfinyl group replaces a carbon atom (for example the terminal or bonding carbon) of the alkyl, alkenyl, or alkynyl substituent group or moiety. Examples include - S(=O)CH ₃ , - S(=O)CH ₂ CH ₃ , - S(=O)CH ₂ CH ₂ CH ₃ , and - S(=O)CH(CH ₃ )(CH ₃ ). An “alkylsulfonyl” substituent group or alkylsulfonyl group in a substituent group refers to an alkyl, alkenyl, or alkynyl substituent group or moiety including one or more carbon atoms and one or more sulfonyl groups (-SO ₂ -). Each sulfonyl group replaces a carbon atom (for example the terminal or bonding carbon) of the alkyl, alkenyl, or alkynyl substituent group or moiety. Examples include – SO2(CH3), - SO2(CH2CH3), - SO ₂ (CH ₂ CH ₂ CH ₃ ), and - SO ₂ (CH(CH ₃ )(CH ₃ )). An “arylsulfonyl” substituent group or arylsulfonyl group in a substituent group refers to an aryl substituent group or moiety including one or more carbon atoms and one or more sulfonyl groups (-SO ₂ -). Each sulfonyl group replaces a carbon atom (for example the terminal or bonding carbon) of the alkyl, alkenyl, or alkynyl substituent group or moiety. Examples include – SO2(CH3), - SO2(CH2CH3), - SO2(CH2CH2CH3), and - SO2(CH(CH3)(CH3)). A “cyclic” substituent group or a cyclic moiety in a substituent group refers to any hydrocarbyl ring, wherein the hydrocarbyl ring may be saturated or unsaturated and may include one or more heteroatoms, e.g. N, O or S, in its carbon skeleton. Examples of cyclic groups include aliphatic cyclic, cycloalkyl, cycloalkenyl, heterocyclic, aryl and heteroaryl groups as discussed below. A cyclic group may be monocyclic, bicyclic (e.g. bridged, fused or spiro), or polycyclic. Typically, a cyclic group is a 3- to 12-membered cyclic group, which means it contains from 3 to 12 ring atoms. More typically, a cyclic group is a 3- to 7-membered monocyclic group, which means it contains from 3 to 7 ring atoms. A “heterocyclic” substituent group or a heterocyclic moiety in a substituent group refers to a cyclic group or moiety including one or more carbon atoms and one or more heteroatoms, e.g. N, O or S, in the ring structure. Examples of heterocyclic groups include heteroaryl groups as discussed below and non-aromatic heterocyclic groups such as azetidinyl, azetinyl, tetrahydrofuranyl, pyrrolidinyl, tetrahydrothiophenyl, tetrahydropyranyl, piperidinyl, piperazinyl, morpholinyl and thiomorpholinyl groups. An “aliphatic cyclic” substituent group or aliphatic cyclic moiety in a substituent group refers to a hydrocarbyl cyclic group or moiety that is not aromatic. The aliphatic cyclic group may be saturated or unsaturated and may include one or more heteroatoms, e.g. N, O or S, in its carbon skeleton. Examples include cyclopropyl, cyclohexyl and morpholinyl. Unless stated otherwise, an aliphatic cyclic substituent group or moiety may include monocyclic, bicyclic or polycyclic hydrocarbyl rings. A “cycloalkyl” substituent group or a cycloalkyl moiety in a substituent group refers to a saturated hydrocarbyl ring containing, for example, from 3 to 7 carbon atoms, examples of which include cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl. Unless stated otherwise, a cycloalkyl substituent group or moiety may include monocyclic, bicyclic or polycyclic hydrocarbyl rings. A “cycloalkenyl” substituent group or a cycloalkenyl moiety in a substituent group refers to a non-aromatic unsaturated hydrocarbyl ring having one or more carbon- carbon double bonds and containing, for example, from 3 to 7 carbon atoms, examples of which include cyclopent-1-en-1-yl, cyclohex-1-en-1-yl and cyclohex-1,3-dien-1-yl. Unless stated otherwise, a cycloalkenyl substituent group or moiety may include monocyclic, bicyclic or polycyclic hydrocarbyl rings. An “aryl” substituent group or an aryl moiety in a substituent group refers to an aromatic hydrocarbyl ring. The term “aryl” includes monocyclic aromatic hydrocarbons and polycyclic fused ring aromatic hydrocarbons wherein all of the fused ring systems (excluding any ring systems which are part of or formed by optional substituents) are aromatic. Examples of aryl groups/moieties include phenyl, naphthyl, anthracenyl and phenanthrenyl. Unless stated otherwise, the term “aryl” does not include “heteroaryl”. A “heteroaryl” substituent group or a heteroaryl moiety in a substituent group refers to an aromatic heterocyclic group or moiety. The term “heteroaryl” includes monocyclic aromatic heterocycles and polycyclic fused ring aromatic heterocycles wherein all of the fused ring systems (excluding any ring systems which are part of or formed by optional substituents) are aromatic. Examples of heteroaryl groups/moieties include the following: wherein G = O, S or NH. For the purposes of the present specification, where a combination of moieties is referred to as one group, for example, arylalkyl, arylalkenyl, arylalkynyl, alkylaryl, alkenylaryl or alkynylaryl, the last mentioned moiety contains the atom by which the group is attached to the rest of the molecule. An example of an arylalkyl group is benzyl. Typically a substituted group comprises 1, 2, 3 or 4 substituents, more typically 1, 2 or 3 substituents, more typically 1 or 2 substituents, and even more typically 1 substituent. Unless stated otherwise, any divalent bridging substituent (e.g. -O-, -S-, -NH-, -N(R ^β )- or -R ^α -) of an optionally substituted group or moiety must only be attached to the specified group or moiety and may not be attached to a second group or moiety, even if the second group or moiety can itself be optionally substituted. The term “halo” includes fluoro, chloro, bromo and iodo. Where reference is made to a carbon atom of a group being replaced by an N, O or S atom, what is intended is that: . is replaced by –CH2– is replaced by –NH–, –O– or –S–; –CH3 is replaced by –NH2, –OH, or –SH; –CH= is replaced by –N=; CH ₂ = is replaced by NH=, O= or S=; or CH≡ is replaced by N≡. In the context of the present specification, unless otherwise stated, a Cx-Cy group is defined as a group containing from x to y carbon atoms. For example, a C1-C4 alkyl group is defined as an alkyl group containing from 1 to 4 carbon atoms. Optional substituents and moieties are not taken into account when calculating the total number of carbon atoms in the parent group substituted with the optional substituents and/or containing the optional moieties. For the avoidance of doubt, replacement heteroatoms, e.g. N, O or S, are counted as carbon atoms when calculating the number of carbon atoms in a C _x -C _y group. For example, a morpholinyl group is to be considered a C ₆ heterocyclic group, not a C4 heterocyclic group. A "protecting group" refers to a grouping of atoms that when attached to a reactive functional group (e.g. OH) in a compound masks, reduces or prevents reactivity of the functional group. In the context of the present specification, = is a double bond; ≡ is a triple bond. The protection and deprotection of functional groups is described in ‘Protective Groups in Organic Synthesis’, 2 ^nd edition, T.W. Greene and P.G.M Wuts, Wiley-Interscience. DETAILLED DESCRIPTION OF THE INVENTION A first aspect of the invention provides a compound of formula (1): Formula (1) wherein: Z is selected from: –NR ¹¹ R ¹² ; –N(R ¹⁰ )-(CH ₂ ) _p –NR ¹¹ R ¹² ; and –N(R ¹⁰ )-(CH ₂ ) _q –N(R ¹⁰ )-(CH ₂ ) _q –NR ¹¹ R ¹² ; R ¹ , R ² , and R ⁴ independently, are selected from –OH, -O-C1-4 alkyl, -OC(O)R13, -OC(O)NHR ¹³ , –OC(O)N(R ¹³ )2; or R ¹ and R ² together form –O-CH2-O-; R ³ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ , independently, are selected from H; halo; -CN; -NO ₂ ; -R ^β ; -OH, -OR ^β ; -SH; -SR ^β ; -SOR ^β ; -SO ₂ H; -SO ₂ R ^β ; -SO ₂ NH ₂ ; -SO ₂ NHR ^β ; -SO ₂ N(R ^β ) ₂ ; -NH2; -NHR ^β ; -N(R ^β )2; -CHO; -COR ^β ; -COOH; -COOR ^β ; -OCOR ^β ; and benzyl optionally substituted with 1-3 -R ^β ; each -R ^β is independently selected from a C ₁ -C ₆ alkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, –O(C ₁ -C ₂ alkyl), or C ₃ -C ₁₄ cyclic group, and wherein any -R ^β may optionally be substituted with one or more C1-C4 alkyl, C1-C4 haloalkyl, C3-C7 cycloalkyl, -O(C1-C4 alkyl), -O(C1-C4 haloalkyl), -O(C3-C7 cycloalkyl), halo, -OH, -NH2, -CN, -NO2, -C≡CH, - CHO, -CON(CH3)2 or oxo (=O) groups; each R ¹⁰ is independently selected from H, C _1-6 alkyl, C ₂ -C ₆ alkenyl, C _2-6 alkynyl, C _3-10 cycloalkyl, and benzyl, wherein each R ¹⁰ , when not H, is independently optionally substituted with 1 or 2 -R ^β ; R ¹¹ and R ¹² are independently selected from H, C1-6-alkyl, C2-C6 alkenyl, C2-6 alkynyl, C _3-10 cycloalkyl, and benzyl, wherein each R ¹¹ and R ¹² , when is not H, are independently optionally substituted with 1 or 2 -R ^β ; or R ¹¹ and R ¹² together form a 5- or 6-membered heterocycle optionally having an additional heteroatom selected from N and O; wherein the 5- or 6-membered heterocycle is optionally substituted with 1 or 2 C _1-4 alkyl, or benzyl; each -R ¹³ is independently selected from a H, C ₁ -C ₆ alkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, C3-14 cyclic group, halo, -NO2, -CN, -OH, -NH2, mercapto, formyl, carboxy, carbamoyl, C1-6 alkoxy, C1-6 alkylthio, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, C1-6 alkylsulfinyl, C _1-6 alkylsulfonyl, or arylsulfonyl, wherein any -R ¹³ may optionally be substituted with one or more –R ¹⁴ ; each R ¹⁴ is independently selected from a C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-14 cyclic group, halo, -NO2, -CN, -OH, -NH2, mercapto, formyl, carboxy, carbamoyl, C _1-6 alkoxy, C _1-6 alkylthio, -NH(C _1-6 alkyl), -N(C _1-6 alkyl) ₂ , C _1-6 alkylsulfinyl, C _1-6 alkylsulfonyl, or arylsulfonyl, wherein any –R ₁₄ may optionally be substituted with one or more –R15; each –R ¹⁵ is independently selected from halogen, nitro, cyano, hydroxy, trifluoromethoxy, trifluoromethyl, amino, formyl, carboxy, carbamoyl, mercapto, sulfamoyl, methyl, ethyl, methoxy, ethoxy, acetyl, acetoxy, methylamino, ethylamino, dimethylamino, diethylamino, N-methyl-N-ethylamino, acetylamino, N- methylcarbamoyl N-ethylcarbamoyl N,N-dimethylcarbamoyl, N,N-diethylcarbamoyl, N-methyl-N-ethylcarbamoyl, methylthio, ethylthio, methylsulfinyl, ethylsulfinyl, mesyl ethylsulfonyl, methoxycarbonyl, ethoxycarbonyl, N-methylsulfamoyl N-ethylsulfamoyl N,N-dimethylsulfamoyl N,N-diethylsulfamoyl, N-methyl-N-ethylsulfamoyl, carbocyclyl, aryl, or heterocyclyl; n = 1-6; each p is independently an integer selected from 1 to 4; and each q is independently an integer selected from 1 to 4. R ¹ , R ² , and R ⁴ , independently, are selected from –OH, -O-C1-4 alkyl, -OC(O)R13, -OC(O)NHR ¹³ , –OC(O)N(R ¹³ )2. In one embodiment, R ¹ , R ² , and R ⁴ , independently, are selected from –OH, and -O-C _1-4 alkyl. In one embodiment, R ¹ , R ² , and R ⁴ , independently, are selected from –OH and -OCH ₃ . In one embodiment, R ¹ and R ² together form –O-CH2-O-. R ³ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ , independently, are selected from H; halo; -CN; -NO ₂ ; -R ^β ; - OH, -OR ^β ; -SH; -SR ^β ; -SOR ^β ; -SO2H; -SO2R ^β ; -SO2NH2; -SO2NHR ^β ; -SO2N(R ^β )2; -NH2; -NHR ^β ; -N(R ^β )2; -CHO; -COR ^β ; -COOH; -COOR ^β ; -OCOR ^β ; and benzyl optionally substituted with 1-3 -R ^β . In one embodiment, R ³ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ , independently, are selected from H; halo; -CN; -NO ₂ ; -R ^β ; -SH; -SR ^β ; -SOR ^β ; -SO ₂ H; -SO ₂ R ^β ; -SO ₂ NH ₂ ; -SO2NHR ^β ; -SO2N(R ^β )2; -NH2; -NHR ^β ; -N(R ^β )2; -CHO; -COR ^β ; -COOR ^β ; and benzyl optionally substituted with 1-3 -R ^β . In one embodiment, R ³ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ , independently, are selected from H; halo; -CN; -NO ₂ ; -R ^β ; -OH; -OR ^β ; -NH ₂ ; -NHR ^β ; -N(R ^β ) ₂ ; -CHO; -COR ^β ; -COOH; -COOR ^β ; and -OCOR ^β . In one embodiment, R ³ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ , independently, are selected from H; halo; -CN; -NO2; -R ^β ; -NH2; -NHR ^β ; -N(R ^β )2; -CHO; -COR ^β ; -COOH; -COOR ^β ; and -OCOR ^β . In one embodiment, R ³ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ , independently, are selected from H; halo; -CN; -NO ₂ ; -R ^β ; -NH ₂ ; -NHR ^β ; -N(R ^β ) ₂ ; -CHO; -COR ^β ; -COOH; and -COOR ^β . In one embodiment, R ³ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ , independently, are selected from H; halo; -CN; -NO2; and -NH2. In one embodiment, R ³ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ , are H. In one embodiment, R ¹ , R ² , and R ⁴ , independently, are selected from –OH, -O-C _1-4 alkyl, -OC(O)R13, -OC(O)NHR ¹³ , –OC(O)N(R ¹³ )2; and R ³ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ , independently, are selected from H; halo; -CN; -NO2; -R ^β ; -SH; -SR ^β ; -SOR ^β ; -SO2H; -SO ₂ R ^β ; -SO ₂ NH ₂ ; -SO ₂ NHR ^β ; -SO ₂ N(R ^β ) ₂ ; -NH ₂ ; -NHR ^β ; -N(R ^β ) ₂ ; -CHO; -COR ^β ; -COOH; -COOR ^β ; -OCOR ^β ; and benzyl optionally substituted with 1-3 -R ^β . In one embodiment, R ¹ , R ² , and R ⁴ , independently, are selected from –OH, and -O-C1-4 alkyl. For example, R ³ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ , are independently selected from H; halo; -CN; -NO ₂ ; -R ^β ; -OH; -OR ^β ; -NH ₂ ; -NHR ^β ; -N(R ^β ) ₂ ; -CHO; -COR ^β ; -COOH; -COOR ^β ; and -OCOR ^β . In one embodiment, R ¹ , R ² , and R ⁴ , independently, are selected from –OH, and -O-C _1-4 alkyl. For example, R ³ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ , are independently selected from H; halo; -CN; -NO2; -R ^β ; -NH2; -NHR ^β ; -N(R ^β )2; -CHO; -COR ^β ; -COOH; -COOR ^β ; and -OCOR ^β . In one embodiment, R ¹ , R ² , and R ⁴ , independently, are selected from –OH, and -OCH ₃ . For example, R ³ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ , are independently selected from H; halo; -CN; -NO2; -R ^β ; -NH2; -NHR ^β ; -N(R ^β )2; -CHO; -COR ^β ; -COOH; -COOR ^β ; and -OCOR ^β . In one embodiment, R ¹ , R ² , and R ⁴ , independently, are selected from –OH, and -OCH ₃ . For example, R ³ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ , are independently selected from H; halo; -CN; -NO2; and -NH2. In one embodiment, R ¹ , R ² , and R ⁴ , independently, are selected from –OH, and -OCH ₃ . For example, R ³ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ , are H. In one embodiment, R ¹ , R ² , and R ⁴ , independently, are selected from –OH, -O-C1-4 alkyl, -OC(O)R ₁₃ , -OC(O)NHR ¹³ , –OC(O)N(R ¹³ ) ₂ ; and R ³ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ , independently, are selected from H; halo; -CN; -NO ₂ ; -R ^β ; -OH, -OR ^β ; -SH; -SR ^β ; -SOR ^β ; -SO2H; -SO2R ^β ; -SO2NH2; -SO2NHR ^β ; -SO2N(R ^β )2; -NH2; -NHR ^β ; -N(R ^β )2; -CHO; -COR ^β ; -COOH; -COOR ^β ; -OCOR ^β ; and benzyl optionally substituted with 1-3 - R ^β . For example, R ³ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ , independently, are selected from H; halo; -CN; -NO ₂ ; -R ^β ; -SH; -SR ^β ; -SOR ^β ; -SO ₂ H; -SO ₂ R ^β ; -SO ₂ NH ₂ ; -SO ₂ NHR ^β ; -SO ₂ N(R ^β ) ₂ ; -NH2; -NHR ^β ; -N(R ^β )2; -CHO; -COR ^β ; -COOH; -COOR ^β ; and benzyl optionally substituted with 1-3 -R ^β . For example, R ³ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ , independently, are selected from H; halo; -CN; -NO ₂ ; -SH; -SO ₂ H; -NH ₂ ; -CHO; -COOH. For example, R ³ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ are H. In one embodiment, R ¹ , R ² , and R ⁴ are independently selected from –OH and -O-C _1-4 alkyl, e.g. –OH and –OCH ₃ ; and R ³ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ , independently, are selected from H; halo; -CN; -NO2; -R ^β ; -OH, -OR ^β ; -SH; -SR ^β ; -SOR ^β ; -SO2H; -SO2R ^β ; -SO2NH2; -SO2NHR ^β ; -SO2N(R ^β )2; -NH2; -NHR ^β ; -N(R ^β )2; -CHO; -COR ^β ; -COOH; -COOR ^β ; -OCOR ^β ; and benzyl optionally substituted with 1-3 -R ^β . For example, R ³ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ , independently, are selected from H; halo; -CN; -NO ₂ ; -R ^β ; -SH; -SR ^β ; -SOR ^β ; -SO2H; -SO2R ^β ; -SO2NH2; -SO2NHR ^β ; -SO2N(R ^β )2; -NH2; -NHR ^β ; -N(R ^β )2; -CHO; -COR ^β ; -COOH; -COOR ^β ; and benzyl optionally substituted with 1-3 -R ^β . For example, R ³ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ , independently, are selected from H; halo; -CN; -NO ₂ ; -SH; -SO ₂ H; -NH ₂ ; -CHO; -COOH. For example, R ³ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ are H. In one embodiment, R ¹ , R ² , and R ⁴ , independently, are selected from –OH and –O-C1-4 alkyl; and R ³ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ , independently, are selected from H; halo; -CN; -NO ₂ ; -SH; -SO ₂ H; and -NH ₂ . For example, R ³ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ are H. In one embodiment, R ¹ , R ² , and R ⁴ , independently, are selected from –OH and –OCH3; and R ³ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ , independently, are selected from H; halo; -CN; -NO ₂ ; -SH; -SO ₂ H; and -NH ₂ . For example, R ³ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ are H. In one embodiment, R ¹ is -O-C1-4 alkyl, e.g. –O-Me; R ² is -OH; R ⁴ is -OH ; and R ³ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ , independently, are selected from H; halo; -CN; -NO ₂ ; -R ^β ; -OH, -OR ^β ; -SH; -SR ^β ; -SOR ^β ; -SO ₂ H; -SO ₂ R ^β ; -SO ₂ NH ₂ ; -SO ₂ NHR ^β ; -SO ₂ N(R ^β ) ₂ ; -NH ₂ ; -NHR ^β ; -N(R ^β )2; -CHO; -COR ^β ; -COOH; -COOR ^β ; -OCOR ^β ; and benzyl optionally substituted with 1-3 -R ^β . For example, R ³ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ , independently, are selected from H; halo; -CN; -NO ₂ ; -R ^β ; -SH; -SR ^β ; -SOR ^β ; -SO ₂ H; -SO ₂ R ^β ; -SO ₂ NH ₂ ; -SO ₂ NHR ^β ; -SO ₂ N(R ^β ) ₂ ; -NH ₂ ; -NHR ^β ; -N(R ^β ) ₂ ; -CHO; -COR ^β ; -COOH; -COOR ^β ; and benzyl optionally substituted with 1-3 -R ^β . For example, R ³ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ , independently, are selected from H; halo; -CN; -NO2; -SH; -SO2H; -NH2; -CHO; -COOH. For example, R ³ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ are H. In one embodiment, R ¹ , R ² , and R ⁴ are -OH ; and R ³ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ , independently, are selected from H; halo; -CN; -NO2; -R ^β ; -OH, -OR ^β ; -SH; -SR ^β ; -SOR ^β ; -SO ₂ H; -SO ₂ R ^β ; -SO ₂ NH ₂ ; -SO ₂ NHR ^β ; -SO ₂ N(R ^β ) ₂ ; -NH ₂ ; -NHR ^β ; -N(R ^β ) ₂ ; -CHO; -COR ^β ; -COOH; -COOR ^β ; -OCOR ^β ; and benzyl optionally substituted with 1-3 - R ^β . For example, R ³ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ , independently, are selected from H; halo; -CN; -NO2; -R ^β ; -SH; -SR ^β ; -SOR ^β ; -SO2H; -SO2R ^β ; -SO2NH2; -SO2NHR ^β ; -SO2N(R ^β )2; -NH ₂ ; -NHR ^β ; -N(R ^β ) ₂ ; -CHO; -COR ^β ; -COOH; -COOR ^β ; and benzyl optionally substituted with 1-3 -R ^β . For example, R ³ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ , independently, are selected from H; halo; -CN; -NO2; -SH; -SO2H; -NH2; -CHO; -COOH. For example, R ³ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ are H. In one embodiment, Z is –NR ¹¹ R ¹² . In one embodiment, Z is –N(R ¹⁰ )-(CH2)p–NR ¹¹ R ¹² . In one embodiment, Z is –N(R ¹⁰ )-(CH ₂ ) _q –N(R ¹⁰ )-(CH ₂ ) _q –NR ¹¹ R ¹² . Each R ¹⁰ is independently selected from H, C1-6 alkyl, C2-C6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, and benzyl, wherein each R ¹⁰ , when not H, is independently optionally substituted with 1 or 2 -R ^β . For example, each R ¹⁰ may independently be selected from H, C1-6 alkyl, and C2-C4 alkenyl. For example, each R ¹⁰ may independently be selected from H, C1-3 alkyl, and C2-C4 alkenyl. For example, each R ¹⁰ is independently selected from H and C _1-6 alkyl. For example, each R ¹⁰ may independently be selected from H and C1-3 alkyl. For example, each R ¹⁰ may independently be selected from H and –CH ₃ . R ¹¹ and R ¹² are independently selected from H, C1-6-alkyl (e.g. methyl or ethyl), C2-C6 alkenyl, C _2-6 alkynyl, C _3-10 cycloalkyl (e.g. adamantyl), and benzyl, wherein each R ¹¹ and R ¹² , when not H, are independently optionally substituted with 1 or 2 -R ^β ; or R ¹¹ and R ¹² together form a 5- or 6-membered heterocycle optionally having an additional heteroatom selected from N and O; wherein the 5- or 6-membered heterocycle is optionally substituted with 1 or 2 C _1-4 alkyl (e.g. methyl) or benzyl. In one embodiment, R ¹¹ and R ¹² are independently selected from H and C1-6 alkyl (e.g. methyl or ethyl), C3-10 cycloalkyl (e.g. adamantyl), and benzyl; or R ¹¹ and R ¹² together form a 5- or 6-membered heterocycle optionally having an additional heteroatom selected from N and O; wherein the 5- or 6-membered heterocycle is optionally substituted with 1 or 2 C1-4 alkyl (e.g. methyl) or benzyl. In one embodiment, R ¹¹ and R ¹² are independently selected from H and C _1-6 alkyl; or R ¹¹ and R ¹² together form a 5- or 6-membered heterocycle optionally having an additional heteroatom selected from N and O; wherein the 5- or 6-membered heterocycle is optionally substituted with 1 or 2 C1-4 alkyl. For example, R ¹¹ and R ¹² are independently selected from H and C _1-6 alkyl (e.g. methyl or ethyl), C3-10 cycloalkyl (e.g. adamantyl), and benzyl; wherein each R ¹¹ and R ¹² , when not H, are independently optionally substituted with 1 or 2 -R ^β . For example, R ¹¹ is H, and R ¹² is selected from H and C _1-6 alkyl (methyl or ethyl), C _3-10 cycloalkyl (e.g. adamantyl), and benzyl; wherein R ¹² , when not H, is optionally substituted with 1 -R ^β . For example, R ¹¹ and R ¹² are both H. For example, R ¹¹ is H, and R ¹² is benzyl, optionally substituted with 1 -R ^β . For example, R ¹¹ is H, and R ¹² is benzyl substituted with methoxy, e.g. R ¹² is ortho-methoxy-benzyl. When R ¹¹ and R ¹² together form a 5- or 6-membered heterocycle as described above, it may be a 5- or 6-membered heterocycle optionally having one additional heteroatom selected from N and O; wherein the 5- or 6-membered heterocycle is optionally substituted with 1 or 2 C _1-4 alkyl. In this respect, the 5- or 6-membered heterocycle may be morpholine, piperidine, piperazine, or pyrrolidine optionally substituted with 1 or 2 C1-4 alkyl. For example, the 5- or 6-membered heterocycle may be piperazine, 4-methyl piperazine, or pyrrolidine. In one embodiment, n is an integer from 3 to 6, for example an integer from 4 to 6. For example, n is 3, 4, 5 or 6. For example, n may be 5. Each -R ^β is independently selected from a C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, – O(C ₁ -C ₂ alkyl), or C ₃ -C ₁₄ cyclic group, and wherein any -R ^β may optionally be substituted with one or more C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₃ -C ₇ cycloalkyl, -O(C ₁ -C ₄ alkyl), -O(C1-C4 haloalkyl), -O(C3-C7 cycloalkyl), halo, -OH, -NH2, -CN, -NO2, -C≡CH, - CHO, -CON(CH3)2 or oxo (=O) groups. For example, each -R ^β is independently selected from a C ₁ -C ₃ alkyl and –O(C ₁ -C ₂ alkyl), and any -R ^β may optionally be substituted with one or more halo, -OH, -NH ₂ , -CN, -NO2, -C≡CH, -CHO, -CON(CH3)2 or oxo (=O) groups. For example, each -R ^β is independently selected from a C1-C3 alkyl and –O(C1-C2 alkyl), and any -R ^β may optionally be substituted with one or more halo, -OH, -NH ₂ , -CN, -NO ₂ , -C≡CH, -CHO, -CON(CH ₃ ) ₂ or oxo (=O) groups. For example, each -R ^β is independently selected from C1-C2 alkyl and –O(C1-C2 alkyl), and any -R ^β may optionally be substituted with one or more halo, -OH, -NH2, -CN, or -NO ₂ groups. Each -R ¹³ is independently selected from a H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-14 cyclic group, halo, -NO2, -CN, -OH, -NH2, mercapto, formyl, carboxy, carbamoyl, C _1-6 alkoxy, C _1-6 alkylthio, -NH(C _1-6 alkyl), -N(C _1-6 alkyl) ₂ , C _1-6 alkylsulfinyl, C _1-6 alkylsulfonyl, or arylsulfonyl, wherein any -R ¹³ may optionally be substituted with one or more –R ¹⁴ . For example, each R ¹³ is independently selected from a H and C ₁ -C ₃ alkyl, wherein any -R ¹³ may optionally be substituted with one or more –R ¹⁴ . For example, each R ¹³ is independently selected from a H and C1-C2 alkyl. Each R ¹⁴ is independently selected from a C ₁ -C ₆ alkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, C _3-14 cyclic group, halo, -NO2, -CN, -OH, -NH2, mercapto, formyl, carboxy, carbamoyl, C1-6 alkoxy, C1-6 alkylthio, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, C1-6 alkylsulfinyl, C1-6 alkylsulfonyl, or arylsulfonyl, wherein any –R ₁₄ may optionally be substituted with one or more –R ₁₅ . For example, each R ¹⁴ is independently selected from a C ₁ -C ₆ alkyl, halo, -NO ₂ , -CN, - OH, -NH2, mercapto, formyl, carboxy, carbamoyl, and C1-6 alkoxy, wherein any –R14 may optionally be substituted with one or more –R15. Each –R ¹⁵ is independently selected from halogen, nitro, cyano, hydroxy, trifluoromethoxy, trifluoromethyl, amino, formyl, carboxy, carbamoyl, mercapto, sulfamoyl, methyl, ethyl, methoxy, ethoxy, acetyl, acetoxy, methylamino, ethylamino, dimethylamino, diethylamino, N-methyl-N-ethylamino, acetylamino, N- methylcarbamoyl N-ethylcarbamoyl N,N-dimethylcarbamoyl, N,N-diethylcarbamoyl, N-methyl-N-ethylcarbamoyl, methylthio, ethylthio, methylsulfinyl, ethylsulfinyl, mesyl ethylsulfonyl, methoxycarbonyl, ethoxycarbonyl, N-methylsulfamoyl N-ethylsulfamoyl N,N-dimethylsulfamoyl N,N-diethylsulfamoyl, N-methyl-N-ethylsulfamoyl, carbocyclyl, aryl, or heterocyclyl. For example, each –R ¹⁵ is independently selected from halogen, nitro, cyano, hydroxy, trifluoromethoxy, trifluoromethyl, amino, formyl, and carboxy. Each p is independently an integer selected from 1 to 4. For example, each p is independently an integer selected from 2 to 4. For example, each p is independently selected from 3 and 4. Each q is independently an integer selected from 1 to 4. For example, each q is independently an integer selected from 2 to 4. For example, each q is independently selected from 3 and 4. For example, Z may be –N(R ¹⁰ )-(CH2)3–N(R ¹⁰ )-(CH2)4–NR ¹¹ R ¹² . For example, Z may be –N(R ¹⁰ )-(CH ₂ ) ₄ –N(R ¹⁰ )-(CH ₂ ) ₃ –NR ¹¹ R ¹² . In one embodiment, Z is –NR ¹¹ R ¹² . For example, Z is –NR ¹¹ R ¹² ; R ¹¹ and R ¹² are independently selected from H; C1-6 alkyl; or R ¹¹ and R ¹² together form a 5- or 6- membered heterocycle optionally having an additional heteroatom selected from N and O; wherein the 5- or 6-membered heterocycle is optionally substituted with 1 or 2 C _1-4 alkyl. In one embodiment, Z is –NR ¹¹ R ¹² and n is 4 to 6. In one embodiment, Z is –N(R ¹⁰ )-(CH2)p–NR ¹¹ R ¹² . For example, Z is –N(R ¹⁰ )-(CH2)p– NR ¹¹ R ¹² ; R ¹⁰ is H or C1-6 alkyl; and R ¹¹ and R ¹² are independently selected from H; C1-6 alkyl, and C _3-10 cycloalkyl; or R ¹¹ and R ¹² together form a 5- or 6-membered heterocycle optionally having an additional heteroatom selected from N and O; wherein the 5- or 6- membered heterocycle is optionally substituted with 1 or 2 C1-4 alkyl; n is an integer from 4 to 6; and p is an integer from 2 to 4. In one embodiment, Z is –N(R ¹⁰ )-(CH ₂ ) _p –NR ¹¹ R ¹² , and n is an integer from 4 to 6, and p is an integer from 2 to 4. In one embodiment, Z is –N(R ¹⁰ )-(CH ₂ ) _q –N(R ¹⁰ )-(CH ₂ ) _q –NR ¹¹ R ¹² ; and q is independently selected from 1-5. For example, q may be 3, 4 or 5. For example, Z is – N(R ¹⁰ )-(CH2)q–N(R ¹⁰ )-(CH2)q–NR ¹¹ R ¹² ; each R ¹⁰ is independently selected from H and C1-6 alkyl; and and R ¹¹ and R ¹² are independently selected from H; C1-6 alkyl; or R ¹¹ and R ¹² together form a 5- or 6-membered heterocycle optionally having an additional heteroatom selected from N and O; wherein the 5- or 6-membered heterocycle is optionally substituted with 1 or 2 C1-4 alkyl. In one embodiment, Z is –N(R ¹⁰ )-(CH ₂ ) _q –N(R ¹⁰ )-(CH ₂ ) _q –NR ¹¹ R ¹² ; and q is independently selected from 3, 4 and 5. In one embodiment, R ¹ is –O(C1-4 alkyl), e.g. –OCH3; R ² is –OH; and R ⁴ is OH. In one embodiment, R ³ , R ⁵ , R ⁷ , R ⁸ and R ⁹ are H, for example as represented by Formula 1A below. In one embodiment, the compound may be a compound of Formula 1A:

Formula (1A) wherein R ¹ , R ² , R ⁴ , R ⁶ , n and Z are as defined herein. For example, the compound may be a compound of Formula (1A) wherein: Z is selected from: –NR ¹¹ R ¹² ; –N(R ¹⁰ )-(CH2)p–NR ¹¹ R ¹² ; and –N(R ¹⁰ )-(CH2)q–N(R ¹⁰ )-(CH2)q–NR ¹¹ R ¹² ; R ¹ , R ² , and R ⁴ independently, are selected from –OH, -O-C1-4 alkyl, -OC(O)R13, -OC(O)NHR ¹³ , –OC(O)N(R ¹³ ) ₂ ; or R ¹ and R ² together form –O-CH ₂ -O-; R ⁶ is selected from H; halo; -CN; -NO2; -R ^β ; -OH, -OR ^β ; -SH; -SR ^β ; -SOR ^β ; -SO2H; -SO2R ^β ; -SO2NH2; -SO2NHR ^β ; -SO2N(R ^β )2; -NH2; -NHR ^β ; -N(R ^β )2; -CHO; -COR ^β ; -COOH; -COOR ^β ; -OCOR ^β ; and benzyl optionally substituted with 1-3 -R ^β ; each -R ^β is independently selected from a C ₁ -C ₆ alkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, –O(C1-C2 alkyl), or C3-C14 cyclic group, and wherein any -R ^β may optionally be substituted with one or more C1-C4 alkyl, C1-C4 haloalkyl, C3-C7 cycloalkyl, -O(C1-C4 alkyl), -O(C ₁ -C ₄ haloalkyl), -O(C ₃ -C ₇ cycloalkyl), halo, -OH, -NH ₂ , -CN, -NO ₂ , -C≡CH, - CHO, -CON(CH3)2 or oxo (=O) groups; each R ¹⁰ is independently selected from H, C _1-6 alkyl, C ₂ -C ₆ alkenyl, C _2-6 alkynyl, C3-10 cycloalkyl, and benzyl, wherein each R ¹⁰ , when not H, is independently optionally substituted with 1 or 2 -R ^β ; R ¹¹ and R ¹² are independently selected from H, C1-6-alkyl, C2-C6 alkenyl, C2-6 alkynyl, C _3-10 cycloalkyl, and benzyl, wherein each R ¹¹ and R ¹² , when is not H, are independently optionally substituted with 1 or 2 -R ^β ; or R ¹¹ and R ¹² together form a 5- or 6-membered heterocycle optionally having an additional heteroatom selected from N and O; wherein the 5- or 6-membered heterocycle is optionally substituted with 1 or 2 C _1-4 alkyl, or benzyl; each -R ¹³ is independently selected from a H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-14 cyclic group, halo, -NO2, -CN, -OH, -NH2, mercapto, formyl, carboxy, carbamoyl, C _1-6 alkoxy, C _1-6 alkylthio, -NH(C _1-6 alkyl), -N(C _1-6 alkyl) ₂ , C _1-6 alkylsulfinyl, C1-6 alkylsulfonyl, or arylsulfonyl, wherein any -R ¹³ may optionally be substituted with one or more –R ¹⁴ ; each R ¹⁴ is independently selected from a C ₁ -C ₆ alkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, C _3-14 cyclic group, halo, -NO ₂ , -CN, -OH, -NH ₂ , mercapto, formyl, carboxy, carbamoyl, C1-6 alkoxy, C1-6 alkylthio, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, C1-6 alkylsulfinyl, C1-6 alkylsulfonyl, or arylsulfonyl, wherein any –R14 may optionally be substituted with one or more –R ₁₅ ; each –R ¹⁵ is independently selected from halogen, nitro, cyano, hydroxy, trifluoromethoxy, trifluoromethyl, amino, formyl, carboxy, carbamoyl, mercapto, sulfamoyl, methyl, ethyl, methoxy, ethoxy, acetyl, acetoxy, methylamino, ethylamino, dimethylamino, diethylamino, N-methyl-N-ethylamino, acetylamino, N- methylcarbamoyl N-ethylcarbamoyl N,N-dimethylcarbamoyl, N,N-diethylcarbamoyl, N-methyl-N-ethylcarbamoyl, methylthio, ethylthio, methylsulfinyl, ethylsulfinyl, mesyl ethylsulfonyl, methoxycarbonyl, ethoxycarbonyl, N-methylsulfamoyl N-ethylsulfamoyl N,N-dimethylsulfamoyl N,N-diethylsulfamoyl, N-methyl-N-ethylsulfamoyl, carbocyclyl, aryl, or heterocyclyl; n = 1-6; each p is independently an integer selected from 1 to 4; and each q is independently an integer selected from 1 to 4. R ¹ , R ² , and R ⁴ , independently, are selected from –OH, -O-C1-4 alkyl, -OC(O)R13, -OC(O)NHR ¹³ , –OC(O)N(R ¹³ )2. In one embodiment, R ¹ , R ² , and R ⁴ , independently, are selected from –OH, and -O-C _1-4 alkyl. In one embodiment, R ¹ , R ² , and R ⁴ , independently, are selected from –OH and -OCH ₃ . In one embodiment, R ¹ and R ² together form –O-CH2-O-. R ⁶ is selected from H; halo; -CN; -NO ₂ ; -R ^β ; -OH, -OR ^β ; -SH; -SR ^β ; -SOR ^β ; -SO ₂ H; -SO2R ^β ; -SO2NH2; -SO2NHR ^β ; -SO2N(R ^β )2; -NH2; -NHR ^β ; -N(R ^β )2; -CHO; -COR ^β ; -COOH; -COOR ^β ; -OCOR ^β ; and benzyl optionally substituted with 1-3 -R ^β . In one embodiment, R ⁶ is selected from H; halo; -CN; -NO ₂ ; -R ^β ; -SH; -SR ^β ; -SOR ^β ; -SO ₂ H; -SO ₂ R ^β ; -SO ₂ NH ₂ ; -SO ₂ NHR ^β ; -SO ₂ N(R ^β ) ₂ ; -NH ₂ ; -NHR ^β ; -N(R ^β ) ₂ ; -CHO; -COR ^β ; -COOR ^β ; and benzyl optionally substituted with 1-3 -R ^β . In one embodiment, R ⁶ is selected from H; halo; -CN; -NO2; -R ^β ; -OH; -OR ^β ; -NH2; -NHR ^β ; -N(R ^β )2; -CHO; -COR ^β ; -COOH; -COOR ^β ; and -OCOR ^β . In one embodiment, R ⁶ is selected from H; halo; -CN; -NO ₂ ; -R ^β ; -NH ₂ ; -NHR ^β ; -N(R ^β ) ₂ ; -CHO; -COR ^β ; -COOH; -COOR ^β ; and -OCOR ^β . In one embodiment, R ⁶ is selected from H; halo; -CN; -NO2; -R ^β ; -NH2; -NHR ^β ; -N(R ^β )2; -CHO; -COR ^β ; -COOH; and -COOR ^β . In one embodiment, R ⁶ is selected from H; halo; -CN; -NO ₂ ; and -NH ₂ . In one embodiment, R ⁶ is H. In one embodiment, R ¹ , R ² , and R ⁴ , independently, are selected from –OH, -O-C1-4 alkyl, -OC(O)R13, -OC(O)NHR ¹³ , –OC(O)N(R ¹³ )2; and R ⁶ is selected from H; halo; -CN; -NO ₂ ; -R ^β ; -SH; -SR ^β ; -SOR ^β ; -SO ₂ H; -SO ₂ R ^β ; -SO ₂ NH ₂ ; -SO ₂ NHR ^β ; -SO ₂ N(R ^β ) ₂ ; -NH ₂ ; -NHR ^β ; -N(R ^β ) ₂ ; -CHO; -COR ^β ; -COOH; -COOR ^β ; -OCOR ^β ; and benzyl optionally substituted with 1-3 -R ^β . In one embodiment, R ¹ , R ² , and R ⁴ , independently, are selected from –OH, and -O-C _1-4 alkyl. For example, R ⁶ is selected from H; halo; -CN; -NO ₂ ; -R ^β ; -OH; -OR ^β ; -NH ₂ ; -NHR ^β ; -N(R ^β )2; -CHO; -COR ^β ; -COOH; -COOR ^β ; and -OCOR ^β . In one embodiment, R ¹ , R ² , and R ⁴ , independently, are selected from –OH, and -O-C _1-4 alkyl. For example, R ⁶ is selected from H; halo; -CN; -NO ₂ ; -R ^β ; -NH ₂ ; -NHR ^β ; -N(R ^β ) ₂ ; -CHO; -COR ^β ; -COOH; -COOR ^β ; and -OCOR ^β . In one embodiment, R ¹ , R ² , and R ⁴ , independently, are selected from –OH, and -OCH ₃ . For example, R ⁶ is selected from H; halo; -CN; -NO ₂ ; -R ^β ; -NH ₂ ; -NHR ^β ; -N(R ^β ) ₂ ; -CHO; -COR ^β ; -COOH; -COOR ^β ; and -OCOR ^β . In one embodiment, R ¹ , R ² , and R ⁴ , independently, are selected from –OH, and -OCH ₃ . For example, R ⁶ is selected from H; halo; -CN; -NO ₂ ; and -NH ₂ . In one embodiment, R ¹ , R ² , and R ⁴ , independently, are selected from –OH, and -OCH3. For example R ⁶ is H. In one embodiment, R ¹ , R ² , and R ⁴ , independently, are selected from –OH, -O-C1-4 alkyl, -OC(O)R13, -OC(O)NHR ¹³ , –OC(O)N(R ¹³ )2; and R ⁶ is selected from H; halo; -CN; -NO ₂ ; -R ^β ; -OH, -OR ^β ; -SH; -SR ^β ; -SOR ^β ; -SO ₂ H; -SO ₂ R ^β ; -SO ₂ NH ₂ ; -SO ₂ NHR ^β ; -SO ₂ N(R ^β ) ₂ ; -NH ₂ ; -NHR ^β ; -N(R ^β ) ₂ ; -CHO; -COR ^β ; -COOH; -COOR ^β ; -OCOR ^β ; and benzyl optionally substituted with 1-3 -R ^β . For example, R ⁶ is selected from H; halo; -CN; -NO2; -R ^β ; -SH; -SR ^β ; -SOR ^β ; -SO2H; -SO2R ^β ; -SO2NH2; -SO2NHR ^β ; -SO2N(R ^β )2; -NH ₂ ; -NHR ^β ; -N(R ^β ) ₂ ; -CHO; -COR ^β ; -COOH; -COOR ^β ; and benzyl optionally substituted with 1-3 -R ^β . For example, R ⁶ is selected from H; halo; -CN; -NO ₂ ; -SH; -SO2H; -NH2; -CHO; -COOH. For example, R ⁶ is H. In one embodiment, R ¹ , R ² , and R ⁴ are independently selected from –OH and -O-C _1-4 alkyl, e.g. –OH and –OCH ₃ ; and R ⁶ is selected from H; halo; -CN; -NO ₂ ; -R ^β ; -OH, -OR ^β ; -SH; -SR ^β ; -SOR ^β ; -SO2H; -SO2R ^β ; -SO2NH2; -SO2NHR ^β ; -SO2N(R ^β )2; -NH2; -NHR ^β ; -N(R ^β )2; -CHO; -COR ^β ; -COOH; -COOR ^β ; -OCOR ^β ; and benzyl optionally substituted with 1-3 -R ^β . For example, R ⁶ is selected from H; halo; -CN; -NO ₂ ; -R ^β ; -SH; -SR ^β ; -SOR ^β ; -SO ₂ H; -SO ₂ R ^β ; -SO ₂ NH ₂ ; -SO ₂ NHR ^β ; -SO ₂ N(R ^β ) ₂ ; -NH ₂ ; -NHR ^β ; -N(R ^β ) ₂ ; -CHO; -COR ^β ; -COOH; -COOR ^β ; and benzyl optionally substituted with 1-3 -R ^β . For example, R ⁶ is selected from H; halo; -CN; -NO2; -SH; -SO2H; -NH2; -CHO; -COOH. For example, R ⁶ is H. In one embodiment, R ¹ , R ² , and R ⁴ , independently, are selected from –OH and –O-C1-4 alkyl; and R ⁶ is selected from H; halo; -CN; -NO2; -SH; -SO2H; and -NH2. For example, R ⁶ is H. In one embodiment, R ¹ , R ² , and R ⁴ , independently, are selected from –OH and –OCH3; and R ⁶ is selected from H; halo; -CN; -NO2; -SH; -SO2H; and -NH2. For example, R ⁶ is H. In one embodiment, R ¹ is -O-C1-4 alkyl, e.g. –O-Me; R ² is -OH; R ⁴ is -OH ; and R ⁶ is selected from H; halo; -CN; -NO2; -R ^β ; -OH, -OR ^β ; -SH; -SR ^β ; -SOR ^β ; -SO2H; -SO2R ^β ; -SO ₂ NH ₂ ; -SO ₂ NHR ^β ; -SO ₂ N(R ^β ) ₂ ; -NH ₂ ; -NHR ^β ; -N(R ^β ) ₂ ; -CHO; -COR ^β ; -COOH; -COOR ^β ; -OCOR ^β ; and benzyl optionally substituted with 1-3 -R ^β . For example, R ⁶ is selected from H; halo; -CN; -NO2; -R ^β ; -SH; -SR ^β ; -SOR ^β ; -SO2H; -SO2R ^β ; -SO2NH2; -SO2NHR ^β ; -SO2N(R ^β )2; -NH2; -NHR ^β ; -N(R ^β )2; -CHO; -COR ^β ; -COOH; -COOR ^β ; and benzyl optionally substituted with 1-3 -R ^β . For example, R ⁶ is selected from H; halo; -CN; -NO ₂ ; -SH; -SO ₂ H; -NH ₂ ; -CHO; -COOH. For example, R ⁶ is H. In one embodiment, R ¹ , R ² , and R ⁴ are -OH ; and R ⁶ is selected from H; halo; -CN; -NO ₂ ; -R ^β ; -OH, -OR ^β ; -SH; -SR ^β ; -SOR ^β ; -SO ₂ H; -SO ₂ R ^β ; -SO ₂ NH ₂ ; -SO ₂ NHR ^β ; -SO ₂ N(R ^β ) ₂ ; -NH ₂ ; -NHR ^β ; -N(R ^β ) ₂ ; -CHO; -COR ^β ; -COOH; -COOR ^β ; -OCOR ^β ; and benzyl optionally substituted with 1-3 -R ^β . For example, R ⁶ is selected from H; halo; -CN; -NO2; -R ^β ; -SH; -SR ^β ; -SOR ^β ; -SO2H; -SO2R ^β ; -SO2NH2; -SO2NHR ^β ; -SO2N(R ^β )2; -NH ₂ ; -NHR ^β ; -N(R ^β ) ₂ ; -CHO; -COR ^β ; -COOH; -COOR ^β ; and benzyl optionally substituted with 1-3 -R ^β . For example, R ⁶ is selected from H; halo; -CN; -NO ₂ ; -SH; -SO2H; -NH2; -CHO; -COOH. For example, R ⁶ is H. In one embodiment, Z is –NR ¹¹ R ¹² . In one embodiment, Z is –N(R ¹⁰ )-(CH2)p–NR ¹¹ R ¹² . In one embodiment, Z is –N(R ¹⁰ )-(CH ₂ ) _q –N(R ¹⁰ )-(CH ₂ ) _q –NR ¹¹ R ¹² . Each R ¹⁰ is independently selected from H, C1-6 alkyl, C2-C6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, and benzyl, wherein each R ¹⁰ , when not H, is independently optionally substituted with 1 or 2 -R ^β . For example, each R ¹⁰ may independently be selected from H, C1-6 alkyl, and C2-C4 alkenyl. For example, each R ¹⁰ may independently be selected from H, C _1-3 alkyl, and C ₂ -C ₄ alkenyl. For example, each R ¹⁰ is independently selected from H and C _1-6 alkyl. For example, each R ¹⁰ may independently be selected from H and C1-3 alkyl. For example, each R ¹⁰ may independently be selected from H and –CH ₃ . R ¹¹ and R ¹² are independently selected from H, C1-6-alkyl (e.g. methyl or ethyl), C2-C6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl (e.g. adamantyl), and benzyl, wherein each R ¹¹ and R ¹² , when not H, are independently optionally substituted with 1 or 2 -R ^β ; or R ¹¹ and R ¹² together form a 5- or 6-membered heterocycle optionally having an additional heteroatom selected from N and O; wherein the 5- or 6-membered heterocycle is optionally substituted with 1 or 2 C1-4 alkyl (e.g. methyl). In one embodiment, R ¹¹ and R ¹² are independently selected from H and C _1-6 alkyl (e.g. methyl or ethyl), C3-10 cycloalkyl (e.g. adamantyl), and benzyl ; or R ¹¹ and R ¹² together form a 5- or 6-membered heterocycle optionally having an additional heteroatom selected from N and O; wherein the 5- or 6-membered heterocycle is optionally substituted with 1 or 2 C1-4 alkyl (e.g. methyl) or benzyl. In one embodiment, R ¹¹ and R ¹² are independently selected from H and C _1-6 alkyl; or R ¹¹ and R ¹² together form a 5- or 6-membered heterocycle optionally having an additional heteroatom selected from N and O; wherein the 5- or 6-membered heterocycle is optionally substituted with 1 or 2 C1-4 alkyl. For example, R ¹¹ and R ¹² are independently selected from H and C _1-6 alkyl (e.g. methyl or ethyl), C3-10 cycloalkyl (e.g. adamantyl), and benzyl; wherein each R ¹¹ and R ¹² , when not H, are independently optionally substituted with 1 or 2 -R ^β . For example, R ¹¹ is H, and R ¹² is selected from H and C _1-6 alkyl (methyl or ethyl), C _3-10 cycloalkyl (e.g. adamantyl), and benzyl; wherein R ¹² , when not H, is optionally substituted with 1 -R ^β . For example, R ¹¹ and R ¹² are both H. For example, R ¹¹ is H, and R ¹² is benzyl, optionally substituted with 1 -R ^β . For example, R ¹¹ is H, and R ¹² is benzyl substituted with methoxy, e.g. R ¹² is ortho-methoxy-benzyl. When R ¹¹ and R ¹² together form a 5- or 6-membered heterocycle as described above, it may be a 5- or 6-membered heterocycle optionally having one additional heteroatom selected from N and O; wherein the 5- or 6-membered heterocycle is optionally substituted with 1 or 2 C _1-4 alkyl. In this respect, the 5- or 6-membered heterocycle may be morpholine, piperidine, piperazine, or pyrrolidine optionally substituted with 1 or 2 C1-4 alkyl. For example, the 5- or 6-membered heterocycle may be piperazine, 4-methyl piperazine, or pyrrolidine. In one embodiment, n is an integer from 3 to 6, for example an integer from 4 to 6. For example, n is 3, 4, 5 or 6. For example, n may be 5. Each -R ^β is independently selected from a C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, – O(C ₁ -C ₆ alkyl), or C ₃ -C ₁₄ cyclic group, and wherein any -R ^β may optionally be substituted with one or more C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₃ -C ₇ cycloalkyl, -O(C ₁ -C ₄ alkyl), -O(C1-C4 haloalkyl), -O(C3-C7 cycloalkyl), halo, -OH, -NH2, -CN, -NO2, -C≡CH, - CHO, -CON(CH3)2 or oxo (=O) groups. For example, each -R ^β is independently selected from a C ₁ -C ₃ alkyl and –O(C ₁ -C ₂ alkyl), and any -R ^β may optionally be substituted with one or more halo, -OH, -NH ₂ , -CN, -NO2, -C≡CH, -CHO, -CON(CH3)2 or oxo (=O) groups. For example, each -R ^β is independently selected from a C1-C3 alkyl and –O(C1-C2 alkyl), and any -R ^β may optionally be substituted with one or more halo, -OH, -NH ₂ , -CN, -NO ₂ , -C≡CH, -CHO, -CON(CH ₃ ) ₂ or oxo (=O) groups. For example, each -R ^β is independently selected from C1-C2 alkyl and –O(C1-C2 alkyl), and any -R ^β may optionally be substituted with one or more halo, -OH, -NH2, -CN, or -NO ₂ groups. Each -R ¹³ is independently selected from a H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-14 cyclic group, halo, -NO2, -CN, -OH, -NH2, mercapto, formyl, carboxy, carbamoyl, C _1-6 alkoxy, C _1-6 alkylthio, -NH(C _1-6 alkyl), -N(C _1-6 alkyl) ₂ , C _1-6 alkylsulfinyl, C _1-6 alkylsulfonyl, or arylsulfonyl, wherein any -R ¹³ may optionally be substituted with one or more –R ¹⁴ . For example, each R ¹³ is independently selected from a H and C ₁ -C ₃ alkyl, wherein any -R ¹³ may optionally be substituted with one or more –R ¹⁴ . For example, each R ¹³ is independently selected from a H and C1-C2 alkyl. Each R ¹⁴ is independently selected from a C ₁ -C ₆ alkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, C _3-14 cyclic group, halo, -NO2, -CN, -OH, -NH2, mercapto, formyl, carboxy, carbamoyl, C1-6 alkoxy, C1-6 alkylthio, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, C1-6 alkylsulfinyl, C1-6 alkylsulfonyl, or arylsulfonyl, wherein any –R ₁₄ may optionally be substituted with one or more –R ₁₅ . For example, each R ¹⁴ is independently selected from a C1-C6 alkyl, halo, -NO2, -CN, - OH, -NH2, mercapto, formyl, carboxy, carbamoyl, and C1-6 alkoxy, wherein any –R14 may optionally be substituted with one or more –R ₁₅ . Each –R ¹⁵ is independently selected from halogen, nitro, cyano, hydroxy, trifluoromethoxy, trifluoromethyl, amino, formyl, carboxy, carbamoyl, mercapto, sulfamoyl, methyl, ethyl, methoxy, ethoxy, acetyl, acetoxy, methylamino, ethylamino, dimethylamino, diethylamino, N-methyl-N-ethylamino, acetylamino, N- methylcarbamoyl N-ethylcarbamoyl N,N-dimethylcarbamoyl, N,N-diethylcarbamoyl, N-methyl-N-ethylcarbamoyl, methylthio, ethylthio, methylsulfinyl, ethylsulfinyl, mesyl ethylsulfonyl, methoxycarbonyl, ethoxycarbonyl, N-methylsulfamoyl N-ethylsulfamoyl N,N-dimethylsulfamoyl N,N-diethylsulfamoyl, N-methyl-N-ethylsulfamoyl, carbocyclyl, aryl, or heterocyclyl. For example, each –R ¹⁵ is independently selected from halogen, nitro, cyano, hydroxy, trifluoromethoxy, trifluoromethyl, amino, formyl, and carboxy. Each p is independently an integer selected from 1 to 4. For example, each p is independently an integer selected from 2 to 4. For example, each p is independently selected from 3 and 4. Each q is independently an integer selected from 1 to 4. For example, each q is independently an integer selected from 2 to 4. For example, each q is independently selected from 3 and 4. For example, Z may be –N(R ¹⁰ )-(CH2)3–N(R ¹⁰ )-(CH2)4–NR ¹¹ R ¹² . For example, Z may be –N(R ¹⁰ )-(CH ₂ ) ₄ –N(R ¹⁰ )-(CH ₂ ) ₃ –NR ¹¹ R ¹² . In one embodiment, Z is –NR ¹¹ R ¹² . For example, Z is –NR ¹¹ R ¹² ; R ¹¹ and R ¹² are independently selected from H; C1-6 alkyl; or R ¹¹ and R ¹² together form a 5- or 6- membered heterocycle optionally having an additional heteroatom selected from N and O; wherein the 5- or 6-membered heterocycle is optionally substituted with 1 or 2 C _1-4 alkyl. In one embodiment, Z is –NR ¹¹ R ¹² and n is 4 to 6. In one embodiment, Z is –N(R ¹⁰ )-(CH2)p–NR ¹¹ R ¹² . For example, Z is –N(R ¹⁰ )-(CH2)p– NR ¹¹ R ¹² ; R ¹⁰ is H or C1-6 alkyl; and R ¹¹ and R ¹² are independently selected from H; C1-6 alkyl, and C _3-10 cycloalkyl; or R ¹¹ and R ¹² together form a 5- or 6-membered heterocycle optionally having an additional heteroatom selected from N and O; wherein the 5- or 6- membered heterocycle is optionally substituted with 1 or 2 C1-4 alkyl; n is an integer from 4 to 6; and p is an integer from 2 to 4. In one embodiment, Z is –N(R ¹⁰ )-(CH ₂ ) _p –NR ¹¹ R ¹² , and n is an integer from 4 to 6, and p is an integer from 2 to 4. In one embodiment, Z is –N(R ¹⁰ )-(CH ₂ ) _q –N(R ¹⁰ )-(CH ₂ ) _q –NR ¹¹ R ¹² ; and q is independently selected from 1-5. For example, q may be 3, 4 or 5. For example, Z is – N(R ¹⁰ )-(CH2)q–N(R ¹⁰ )-(CH2)q–NR ¹¹ R ¹² ; each R ¹⁰ is independently selected from H and C1-6 alkyl; and and R ¹¹ and R ¹² are independently selected from H; C1-6 alkyl; or R ¹¹ and R ¹² together form a 5- or 6-membered heterocycle optionally having an additional heteroatom selected from N and O; wherein the 5- or 6-membered heterocycle is optionally substituted with 1 or 2 C1-4 alkyl. In one embodiment, Z is –N(R ¹⁰ )-(CH ₂ ) _q –N(R ¹⁰ )-(CH ₂ ) _q –NR ¹¹ R ¹² ; and q is independently selected from 3, 4 and 5. In one embodiment, R ¹ is –O(C1-4 alkyl), e.g. –OCH3; R ² is –OH; and R ⁴ is OH. A second aspect of the invention provides a compound selected from the compounds listed in Table A. Table A: A third aspect of the invention provides pharmaceutically acceptable salt, multi-salt, solvate or prodrug of the compound of the first or second aspect of the invention. The compounds of the present invention can be used both in their quaternary salt form (as a single salt). Additionally, the compounds of the present invention may contain one or more (e.g. one or two) acid addition or alkali addition salts to form a multi-salt. A multi-salt includes a quaternary salt group as well as a salt of a different group of the compound of the invention. For the purposes of this invention, a “multi-salt” of a compound of the present invention includes an acid addition salt. Acid addition salts are preferably pharmaceutically acceptable, non-toxic addition salts with suitable acids, including but not limited to inorganic acids such as hydrohalogenic acids (for example, hydrofluoric, hydrochloric, hydrobromic or hydroiodic acid) or other inorganic acids (for example, nitric, perchloric, sulfuric or phosphoric acid); or organic acids such as organic carboxylic acids (for example, propionic, butyric, glycolic, lactic, mandelic, citric, acetic, benzoic, salicylic, succinic, malic or hydroxysuccinic, tartaric, fumaric, maleic, hydroxymaleic, mucic or galactaric, gluconic, pantothenic or pamoic acid), organic sulfonic acids (for example, methanesulfonic, trifluoromethanesulfonic, ethanesulfonic, 2-hydroxyethanesulfonic, benzenesulfonic, toluene-p-sulfonic, naphthalene-2-sulfonic or camphorsulfonic acid) or amino acids (for example, ornithinic, glutamic or aspartic acid). The acid addition salt may be a mono-, di-, tri- or multi-acid addition salt. A preferred salt is a hydrohalogenic, sulfuric, phosphoric or organic acid addition salt. A preferred salt is a hydrochloric acid addition salt. The compounds of the present invention can be used both, in quaternary salt form and their multi-salt form. For the purposes of this invention, a “multi-salt” of a compound of the present invention includes one formed between a protic acid functionality (such as a carboxylic acid group) of a compound of the present invention and a suitable cation. Suitable cations include, but are not limited to lithium, sodium, potassium, magnesium, calcium and ammonium. The salt may be a mono-, di-, tri- or multi-salt. Preferably the salt is a mono- or di-lithium, sodium, potassium, magnesium, calcium or ammonium salt. More preferably the salt is a mono- or di-sodium salt or a mono- or di- potassium salt. Preferably any multi-salt is a pharmaceutically acceptable non-toxic salt. However, in addition to pharmaceutically acceptable multi-salts, other salts are included in the present invention, since they have potential to serve as intermediates in the purification or preparation of other, for example, pharmaceutically acceptable salts, or are useful for identification, characterisation or purification of the free acid or base. The compounds and/or multi-salts of the present invention may be anhydrous or in the form of a hydrate (e.g. a hemihydrate, monohydrate, dihydrate or trihydrate) or other solvate. Such solvates may be formed with common organic solvents, including but not limited to, alcoholic solvents e.g. methanol, ethanol or isopropanol. In some embodiments of the present invention, therapeutically inactive prodrugs are provided. Prodrugs are compounds which, when administered to a subject such as a human, are converted in whole or in part to a compound of the invention. In most embodiments, the prodrugs are pharmacologically inert chemical derivatives that can be converted in vivo to the active drug molecules to exert a therapeutic effect. Any of the compounds described herein can be administered as a prodrug to increase the activity, bioavailability, or stability of the compound or to otherwise alter the properties of the compound. Typical examples of prodrugs include compounds that have biologically labile protecting groups on a functional moiety of the active compound. Prodrugs include, but are not limited to, compounds that can be oxidized, reduced, aminated, deaminated, hydroxylated, dehydroxylated, hydrolyzed, dehydrolyzed, alkylated, dealkylated, acylated, deacylated, phosphorylated, and/or dephosphorylated to produce the active compound. The present invention also encompasses multi-salts and solvates of such prodrugs as described above. The compounds, multi-salts, solvates and prodrugs of the present invention may contain at least one chiral centre. The compounds, multi-salts, solvates and prodrugs may therefore exist in at least two isomeric forms. The present invention encompasses racemic mixtures of the compounds, multi-salts, solvates and prodrugs of the present invention as well as enantiomerically enriched and substantially enantiomerically pure isomers. For the purposes of this invention, a “substantially enantiomerically pure” isomer of a compound comprises less than 5% of other isomers of the same compound, more typically less than 2%, and most typically less than 0.5% by weight. The compounds, multi-salts, solvates and prodrugs of the present invention may contain any stable isotope including, but not limited to ¹² C, ¹³ C, ¹ H, ² H (D), ¹⁴ N, ¹⁵ N, ¹⁶ O, ¹⁷ O, ¹⁸ O, and ¹²⁷ I, and any radioisotope including, but not limited to ¹¹ C, ¹⁴ C, ³ H (T), ¹³ N, ¹⁵ O, ¹⁸ F, ¹²³ I, ¹²⁴ I, ¹²⁵ I and ¹³¹ I. The compounds, multi-salts, solvates and prodrugs of the present invention may be in any polymorphic or amorphous form. A fourth aspect of the invention provides a pharmaceutical composition comprising a compound of the first or second aspect of the invention, or a pharmaceutically acceptable multi-salt, solvate or prodrug of the third aspect of the invention, and a pharmaceutically acceptable excipient. Conventional procedures for the selection and preparation of suitable pharmaceutical formulations are described in, for example, “Aulton’s Pharmaceutics - The Design and Manufacture of Medicines”, M. E. Aulton and K. M. G. Taylor, Churchill Livingstone Elsevier, 4 ^th Ed., 2013. Pharmaceutically acceptable excipients including adjuvants, diluents or carriers that may be used in the pharmaceutical compositions of the invention are those conventionally employed in the field of pharmaceutical formulation, and include, but are not limited to, sugars, sugar alcohols, starches, ion exchangers, alumina, aluminium stearate, lecithin, serum proteins such as human serum albumin, buffer substances such as phosphates, glycerine, sorbic acid, potassium sorbate, partial glyceride mixtures of saturated vegetable fatty acids, water, salts or electrolytes such as protamine sulfate, disodium hydrogen phosphate, potassium hydrogen phosphate, sodium chloride, zinc salts, colloidal silica, magnesium trisilicate, polyvinylpyrrolidone, cellulose-based substances, polyethylene glycol, sodium carboxymethylcellulose, polyacrylates, waxes, polyethylene-polyoxypropylene-block polymers, polyethylene glycol and wool fat. A fifth aspect of the invention provides a compound of the first or second aspect of the invention, or a pharmaceutically acceptable multi-salt, solvate or prodrug of the third aspect of the invention, or a pharmaceutical composition of the fourth aspect of the invention, for use in medicine, and/or for use in the treatment or prevention of a disease, disorder or condition. Typically the use comprises the administration of the compound, multi-salt, solvate, prodrug or pharmaceutical composition to a subject. In one embodiment, the disease, disorder or condition is cancer. A sixth aspect of the invention provides the use of a compound of the first or second aspect, a pharmaceutically effective multi-salt, solvate or prodrug of the third aspect, or a pharmaceutical composition according to the fourth aspect, in the manufacture of a medicament for the treatment or prevention of a disease, disorder or condition. Typically the treatment or prevention comprises the administration of the compound, multi-salt, solvate, prodrug or pharmaceutical composition to a subject. In one embodiment, the disease, disorder or condition is cancer. A seventh aspect of the invention provides a method of treatment or prevention of a disease, disorder or condition, the method comprising the step of administering an effective amount of a compound of the first or second aspect, or a pharmaceutically acceptable multi-salt, solvate or prodrug of the third aspect, or a pharmaceutical composition of the fourth aspect, to thereby treat or prevent the disease, disorder or condition. Typically the administration is to a subject in need thereof. In one embodiment, the disease, disorder or condition is cancer. The term “treatment” as used herein refers equally to curative therapy, and ameliorating or palliative therapy. The term includes obtaining beneficial or desired physiological results, which may or may not be established clinically. Beneficial or desired clinical results include, but are not limited to, the alleviation of symptoms, the prevention of symptoms, the diminishment of extent of disease, the stabilisation (i.e., not worsening) of a condition, the delay or slowing of progression/worsening of a condition/symptoms, the amelioration or palliation of the condition/symptoms, and remission (whether partial or total), whether detectable or undetectable. The term “palliation”, and variations thereof, as used herein, means that the extent and/or undesirable manifestations of a physiological condition or symptom are lessened and/or time course of the progression is slowed or lengthened, as compared to not administering a compound, multi-salt, solvate, prodrug or pharmaceutical composition of the present invention. The term “prevention” as used herein in relation to a disease, disorder or condition, relates to prophylactic or preventative therapy, as well as therapy to reduce the risk of developing the disease, disorder or condition. The term “prevention” includes both the avoidance of occurrence of the disease, disorder or condition, and the delay in onset of the disease, disorder or condition. Any statistically significant avoidance of occurrence, delay in onset or reduction in risk as measured by a controlled clinical trial may be deemed a prevention of the disease, disorder or condition. Subjects amenable to prevention include those at heightened risk of a disease, disorder or condition as identified by genetic or biochemical markers. Typically, the genetic or biochemical markers are appropriate to the disease, disorder or condition under consideration and may include for example, beta-amyloid 42, tau and phosphor-tau. In one embodiment of the fifth, sixth, or seventh aspect of the present invention, the disease, disorder or condition is selected from but not limited to: breast cancer, brain cancer, colon cancer, lung cancer, leukaemia, melanoma, renal cancer, prostate cancer and pancreatic cancer. The cancers may include resistant types of such tumors. For example, the disease, disorder or condition is selected from but not limited to: breast cancer, brain cancer, colon cancer, lung cancer, leukaemia, and melanoma. In general embodiments, the disease, disorder or condition is cancer. In one embodiment the cancer is brain cancer. In one embodiment the cancer is breast cancer. In one embodiment the cancer is colon cancer. In one embodiment the cancer is leukaemia. In one embodiment the cancer is lung cancer. In one embodiment the cancer is ovarian cancer. In one embodiment the cancer is pancreatic cancer. In one embodiment the cancer is prostate cancer. In one embodiment the cancer is renal cancer. Unless stated otherwise, in any aspect of the invention, the subject may be any human or other animal. Typically, the subject is a mammal, more typically a human or a domesticated mammal such as a cow, pig, lamb, goat, horse, cat, dog, etc. Most typically, the subject is a human. Any of the medicaments employed in the present invention can be administered by oral, parental (including intravenous, subcutaneous, intramuscular, intradermal, intratracheal, intraperitoneal, intraarticular, intracranial and epidural), airway (aerosol), rectal, vaginal or topical (including transdermal, buccal, mucosal and sublingual) administration. Typically, the mode of administration selected is that most appropriate to the disorder or disease to be treated or prevented. For oral administration, the compounds, multi-salts, solvates or prodrugs of the present invention will generally be provided in the form of tablets, capsules, hard or soft gelatine capsules, caplets, troches or lozenges, as a powder or granules, or as an aqueous solution, suspension or dispersion. Tablets for oral use may include the active ingredient mixed with pharmaceutically acceptable excipients such as inert diluents, disintegrating agents, binding agents, lubricating agents, sweetening agents, flavouring agents, colouring agents and preservatives. Suitable inert diluents include sodium and calcium carbonate, sodium and calcium phosphate, and lactose. Corn starch and alginic acid are suitable disintegrating agents. Binding agents may include starch and gelatine. The lubricating agent, if present, may be magnesium stearate, stearic acid or talc. If desired, the tablets may be coated with a material, such as glyceryl monostearate or glyceryl distearate, to delay absorption in the gastrointestinal tract. Tablets may also be effervescent and/or dissolving tablets. Capsules for oral use include hard gelatine capsules in which the active ingredient is mixed with a solid diluent, and soft gelatine capsules wherein the active ingredient is mixed with water or an oil such as peanut oil, liquid paraffin or olive oil. Powders or granules for oral use may be provided in sachets or tubs. Aqueous solutions, suspensions or dispersions may be prepared by the addition of water to powders, granules or tablets. Any form suitable for oral administration may optionally include sweetening agents such as sugar, flavouring agents, colouring agents and/or preservatives. Formulations for rectal administration may be presented as a suppository with a suitable base comprising, for example, cocoa butter or a salicylate. Formulations suitable for vaginal administration may be presented as pessaries, tampons, creams, gels, pastes, foams or spray formulations containing in addition to the active ingredient such carriers as are known in the art to be appropriate. For parenteral use, the compounds, multi-salts, solvates or prodrugs of the present invention will generally be provided in a sterile aqueous solution or suspension, buffered to an appropriate pH and isotonicity. Suitable aqueous vehicles include Ringer’s solution and isotonic sodium chloride or glucose. Aqueous suspensions according to the invention may include suspending agents such as cellulose derivatives, sodium alginate, polyvinylpyrrolidone and gum tragacanth, and a wetting agent such as lecithin. Suitable preservatives for aqueous suspensions include ethyl and n-propyl p- hydroxybenzoate. The compounds of the invention may also be presented as liposome formulations. For transdermal and other topical administration, the compounds, multi-salts, solvates or prodrugs of the invention will generally be provided in the form of ointments, cataplasms (poultices), pastes, powders, dressings, creams, plasters or patches. Suitable suspensions and solutions can be used in inhalers for airway (aerosol) administration. The dose of the compounds, multi-salts, solvates or prodrugs of the present invention will, of course, vary with the disorder or disease to be treated or prevented. In general, a suitable dose will be in the range of 0.01 to 500 mg per kilogram body weight of the recipient per day. The desired dose may be presented at an appropriate interval such as once every other day, once a day, twice a day, three times a day or four times a day. The desired dose may be administered in unit dosage form, for example, containing 1 mg to 50 g of active ingredient per unit dosage form. For the avoidance of doubt, insofar as is practicable any embodiment of a given aspect of the present invention may occur in combination with any other embodiment of the same aspect of the present invention. In addition, insofar as is practicable it is to be understood that any preferred, typical or optional embodiment of any aspect of the present invention should also be considered as a preferred, typical or optional embodiment of any other aspect of the present invention. EXAMPLES – SYNTHEIS OF COMPOUNDS Synthesis of SND351-354 The synthesis of compounds SND351 to SND354 is based on the scheme depicted below. 2-(Pent-4-en-1-yloxy)tetrahydro-2H-pyran (20.8a) p-Toluenesulfonic acid monohydrate (0.45 g, 0.020 Eq, 2.4 mmol) and 3,4- dihydro-2H-pyran (20.3 g, 22 mL, 2 Eq, 241 mmol) were added to a solution of pent-4-en-1-ol (10.4 g, 12.5 mL, 1 Eq, 121 mmol) in DCM (50 mL) at 0°C. After 2 hours the reaction mixture was quenched with sat. NaHCO3. (50 mL). It was then diluted with DCM (50 mL) and the layers were separated. Organic layer was washed with water (50 mL) and brine (50 mL), before it was dried with sodium sulfate, filtered and evaporated to dryness. The crude product was obtained as a dark oil (31.3 g). The crude product was applied on the column neat. It was then purified by column chromatography over 330 g of silica using Heptane/EtOAc as eluents. This obtained a pure fraction of 20.8a (16.88 g, 99.15 mmol, 82 %) as a faintly yellow transparent oil. 4-(5-((Tetrahydro-2H-pyran-2-yl)oxy)pentyl)benzaldehyde (20.9a) 9-BBN (7.59 g, 62.2 mL, 0.5 molar, 1.48 Eq, 31.1 mmol) in THF was added to 20.8a (5.29 g, 1.47 Eq, 31.1 mmol) at room temperature under nitrogen flow in a flame-dried three-neck flask. The mixture was stirred at room temperature under nitrogen for 24 hours. Then aq. NaOH (1.24 g, 10.3 mL, 3 molar, 1.47 Eq, 31.0 mmol) was added. After the reaction mixture was left to stir for 20 minutes, 4-bromobenzaldehyde (3.90 g, 1 Eq, 21.1 mmol) was added with degassed THF (30 mL). The mixture was degassed for a further 30 mins. Pd(PPh3)4 (2.00 g, 0.0821 Eq, 1.73 mmol) added as solid. The mixture was degassed for 45 mins. The reaction was heated at 60°C for 2 hours, after which the reaction was complete. The reaction mixture was diluted with EtOAc (750 mL) and washed with sat. NaHCO3 (400 mL). The aqueous layer was extracted with EtOAc (2 x 150 mL). The organic layers were combined, dried with sodium sulfate, filtered and evaporated to dryness to yield brown oil with precipitate (13.984g). This was purified over 330 g of silica using Heptane/EtOAc as eluents. This obtained an impure fraction of 20.9a (6.88 g, > quant. yield) (E)-1-(4,6-bis(benzyloxy)-2-hydroxy-3-methoxyphenyl)-3-(4-(5 - ((tetrahydro-2H-pyran-2-yl)oxy)pentyl)phenyl)prop-2-en-1-one (20.10) Sodium methanolate (7.619 g, 26.12 mL, 5.4 molar, 35 Eq, 141.0 mmol) in MeOH was added portion-wise under nitrogen flow to an ice/water cooled (10 °C) suspension of 20.3 (1.525 g, 1 Eq, 4.030 mmol) and 20.9a (1.78 g, 1.60 Eq, 6.44 mmol) in 1,4-Dioxane (30 mL). This took 15 minutes, and the solution turned yellow after sodium methoxide solution was added . The mixture was allowed slowly to warm to room temperature and it was stirred for 20 hours under nitrogen atmosphere. The resultant dark reaction mixture was neutralised with (10% aq) citric acid, under ice-bath, until pH was neutral. The orange suspension was extracted with EtOAc (4 x 90 mL). Organic layers were combined, dried with sodium sulfate, filtered and concentrated. This gave a crude orange oil (3.88 g). This was purified by column chromatography over a 120 g column, using EtOAc/Heptane as an eluent. This gave a pure fraction of 20.10 (2.609 g, 4.03 mmol, 100% yield, >99% purity). 5,7-bis(benzyloxy)-2-(4-(5-hydroxypentyl)phenyl)-8-methoxy-4 H- chromen-4-one (20.11) A solution of 20.10 (1.95 g, 1 Eq, 3.06 mmol) and diiodine (50 mg, 0.064 Eq, 0.20 mmol) in DMSO (48 mL) were stirred at 120 °C for 20 hours. The reaction mixture was allowed to cool to room temperature, before pouring it to 460 mL of 2% sodium thiosulfate solution. Brown suspension formed. This was filtered. The residue was dissolved and washed from the filter using THF. This was dried with sodium sulphate and filtered. The solvent was removed which yielded a brown solid (4.35 g). This was purified by column chromatography over a 220 g silica column, using EtOAc/DCM as an eluent. This gave a fraction of impure 20.11 (1.692g), with significant DMSO impurities. A second column over 80g silica with THF/DCM eluent was carried out, this obtained a main fraction of 20.11 (0.928 g, 1.69 mmol, 55% yield, 100% purity). There is only 0.13 eq of DMSO by NMR. 5,7-dihydroxy-2-(4-(5-hydroxypentyl)phenyl)-8-methoxy-4H- chromen-4-one (20.12a) Pd/C (1.31 g, 10% Wt, 0.731 Eq, 1.23 mmol) was added to a flask. A solution of 20.11 (0.9276 g, 1.0 Eq, 1.685 mmol) in THF (80 mL) was added. After purging with nitrogen, a hydrogen balloon was added. The reaction was monitored for 6 hours until completion by LCMS. After that hydrogen was removed and reaction mixture filtered over celite by THF (300 mL). This obtained a yellow/green solid (616 mg, 1.663 mmol, 99% yield, 90% purity). Major impurity is BHT from the THF. 2-(4-(5-bromopentyl)phenyl)-5,7-dihydroxy-8-methoxy-4H-chrom en- 4-one (20.12) 20.11 (1.951 g, 1.0 Eq, 3.543 mmol), N,N-dimethylformamide (1.5 g, 1.6 mL, 5.9 Eq, 21 mmol), and DCM (44 mL) were transferred to a vial. The suspension was cooled to 0 °C by ice cooling bath and then drop-wise addition of sulfurous dibromide (1.031 g, 384.7 µL, 1.4 Eq, 4.960 mmol). The ice was removed after 10 minutes. The reaction was followed for 2 hours, and then quenched with sat. NaHCO3;water (1:140 mL). The aqueous layer was extracted with DCM (3 x 70 mL). The combined organic layers dried with sodium sulfate, filtered and concentrated. This gave crude product as a brown oil (2.905 g). This was combined with the crude reaction mixtures of other identical reactions, which were a combined 0.825 mmol scale. The crude mixture was purified by column chromatography over a 40 g silica column, using MeOH/DCM as an eluent. This yielded 20.12 as a brown oil (1.937 g, 3.16 mmol, 79% yield, 95% purity). 2-(4-(5-bromopentyl)phenyl)-5,7-dihydroxy-8-methoxy-4H-chrom en- 4-one (20.13) – 1 ^st route 20.12a (616 mg, 1.0 Eq, 1.66 mmol) N,N-dimethylformamide (1.9 g, 2.0 mL, 16 Eq, 26 mmol), and DCM (10 mL) were transferred to a vial. The suspension was cooled to 0°C and 1H-benzo[d][1,2,3]triazole (337 mg, 1.7 Eq, 2.83 mmol) and were added, followed by drop-wise addition of sulfurous dibromide (373 mg, 139 µL, 1.08 Eq, 1.80 mmol). The reaction was carefully monitored by LCMS to allow the reaction to progress to the optimum point – maximum amount of conversion to 20.13, and minimal conversion to the over-brominated byproducts. After 2 hours the reaction was quenched by with 16 mL of 1:1 water:sat. NaHCO3. Additional LiCl (20%, 5 mL) was added. The aqueous layer was extracted with DCM (4 x 15 mL). The combined organic layers dried with sodium sulfate, filtered and concentrated to yield crude 20.13 as a brown oil (1.293 g). This was purified by column chromatography over a 40 g silica column, using EtOAc/DCM as an eluent. This yielded 20.13 as a yellow solid (240 mg, 553 µmol, 33% yield, 96% purity). 2-(4-(5-bromopentyl)phenyl)-5,7-dihydroxy-8-methoxy-4H-chrom en- 4-one (20.13) – 2 ^nd route Pd/C (1.158 g, 10% Wt, 0.35 Eq, 1.088 mmol) was added to a flask. A solution of 20.12 (1.908 g, 1 Eq, 3.110 mmol) in THF (100 mL) was added. After purging with nitrogen, a hydrogen balloon was added. The reaction reached completion within 3.5 hours. The reaction was worked up by filtering over celite with THF (400 mL). The solvent was evaporated to give yellow solid. This was purified by column chromatography over a 40 g silica column, using MeOH/DCM as an eluent. This yielded 20.13 as a yellow solid (1.160 g, 2.677 mmol, 86% yield, >99% purity). 2-(4-(5-(((3s,5s,7s)-adamantan-1-yl)(methyl)amino)pentyl)phe nyl)- 5,7-dihydroxy-8-methoxy-4H-chromen-4-one hydrochloride (20R) (SND 351) A solution of amine R (118.8 mg, 2.5 Eq, 718.9 µmol) and N-ethyl-N- isopropylpropan-2-amine (55.75 mg, 75.1 µL, 1.5 Eq, 431.3 µmol) in DMF (4 mL) was added to a suspension of 20.13 (124.6 mg, 1 Eq, 287.6 µmol) in DMF (2 mL) under nitrogen flow. The reaction was heated at 80°C for 22 hours. After the heat was turned off, it was combined with a smaller scale reaction (35.1 µmol of 20.13). The reaction mixture was dissolved in DCM (60 mL), which was washed with 20 mL of brine:water 1:1 mixture. The aqueous layer was extracted with DCM (3 x 10 mL). Organic layers were combined, dried with sodium sulfate, and evaporated to give crude 20R (218 mg). This was purified by column chromatography over a 12 g silica column, using DCM/MeOH (3.5 M NH3) as eluents. This yielded impure 20R (83 mg). This was converted into the HCl salt by dissolving it in anhydrous DCM (5 mL) and then adding HCl (522 mg, 0.350 mL, 4 molar, 4.87 Eq, 1.40 mmol). The solvent was removed to give yellow powder (101 mg). This was purified by acidic Prep chromatography. This yielded pure 20R as a yellow solid (57 mg, 102 µmol, 36% yield, 98.9% purity). 5,7-dihydroxy-8-methoxy-2-(4-(5-(methyl(3-(piperidin-1- yl)propyl)amino)pentyl)phenyl)-4H-chromen-4-one dihydrochloride (20K) (SND 352) A solution of amine K (177 mg, 200 µL, 2.45 Eq, 1.13 mmol) and N-ethyl-N- isopropylpropan-2-amine (89.5 mg, 121 µL, 1.5 Eq, 692 µmol) in DMF (4 mL) was added to a suspension of 20.13 (200 mg, 1 Eq, 462 µmol) in DMF (2 mL) under nitrogen flow. The reaction was heated at 80°C for hours. The reaction mixture was dissolved in DCM (60 mL), which was washed with brine:water (1:1, 30 mL). The aqueous layer was extracted with DCM (3 x 10 mL). The organic layers were combined, dried with sodium sulfate, filtered and evaporated to dryness, yielding an orange oil (344.3 mg). This was purified by column chromatography over a 12 g silica column, using DCM/MeOH (3.5 M NH ₃ ) as eluents. This yielded impure 20K (274 mg). This was converted into the HCl salt by dissolving it in anhydrous DCM (6 mL) and then adding HCl (0.7 g, 0.5 mL, 4 molar, 4 Eq, 2 mmol). The solvent was removed to give yellow powder (310 mg). This was purified by acidic Prep chromatography. This yielded pure 20K as an orange amorphous solid (180 mg, 310 µmol, 67% yield, 98.8% purity). 2-(4-(5-bromopentyl)phenyl)-5-hydroxy-8-methoxy-7- (methoxymethoxy)-4H-chromen-4-one (20.14) MOM-Cl (77.77 mg, 73.37 µL, 1.2 Eq, 966.0 µmol) was added drop-wise under nitrogen flow to a suspension of 20.13 (0.3488 g, 1 Eq, 805.0 µmol) and DIPEA (260.1 mg, 351 µL, 2.5 Eq, 2.012 mmol) in DCM (6 mL) at 0°C. The reaction was followed by LCMS and quenched after 1 hour, by diluting the mixture with DCM (10 mL) and washed with citric acid (5%, 10 mL). The aqueous layer was extracted with 3 × 5 ml of DCM. Organic layers were combined, dried with sodium sulfate, filtered and concentrated. This gave 20.14 as a beige solid (399 mg, 0.80 mmol, 100% yield, 96% purity). 2-(4-(5-(ethyl(2-methoxybenzyl)amino)pentyl)phenyl)-5,7-dihy droxy- 8-methoxy-4H-chromen-4-one, hydrochloride (20L) (SND 354) Amine L.HCl (254 mg, 3 Eq, 1.26 mmol), KI (13.9 mg, 0.2 Eq, 83.8 µmol) and K ₂ CO ₃ (353 mg, 6.1 Eq, 2.56 mmol) were suspended in DMF (1.5 mL) to convert the amine into the free base. After 10 min 20.14 (200 mg, 1 Eq, 419 µmol) was added as a suspension in DMF (3 mL). The mixture was stirred at 60 °C for 18 hours. The reaction mixture was allowed to cool to room temperature, diluted with DCM (30 mL) and washed with a water:brine mixture (1:1, 12 mL) . The aqueous layer was extracted with DCM (2 × 10 ml). Organic layers were combined, dried with sodium sulfate, filtered and evaporated to dryness, yielding a brown oil (356 mg). This was purified by column chromatography over a 12 g silica column, using DCM/MeOH (3.5 M NH ₃ ) as eluents. This yielded impure intermediate (183 mg). The crude intermediate was dissolved in MeCN (2 mL), before HCl (145 mg, 1 mL, 4 molar, 9.5 Eq, 4 mmol) was added. The reaction was stirred for 75 minutes, and then the solvent removed to give a yellow solid (228 mg). This was purified by reverse phase chromatography to give pure 20L as a yellow powder (125 mg, 0.226 mmol, 54% yield, 95.6% purity). 2-(4-(5-((4-((3-aminopropyl)amino)butyl)amino)pentyl)phenyl) -5,7- dihydroxy-8-methoxy-4H-chromen-4-one, trihydrochloride (20H) (SND 353) K ₂ CO ₃ (116 mg, 2 Eq, 838 µmol), KI (13.9 mg, 0.2 Eq, 83.8 µmol), 20.14 (200 mg, 1 Eq, 419 µmol) amine H (267 mg, 1.84 Eq, 773 µmol) were suspended in dry DMF (6 mL). The mixture was then purged with nitrogen, sonicated and was left stirring at room temperature for 18 hours. After that the reaction was heated to 50°C for 4 hours, before being left at 40°C for 21 hours. The reaction mixture was allowed to cool to room temperature, diluted with DCM (50 mL) and washed with a water:brine mixture (1:1, 20 mL) . The aqueous layer was extracted with DCM (2 × 10 ml). Organic layers were combined, dried with sodium sulfate, filtered and evaporated to dryness, yielding a brown oil (448 mg). This was purified by column chromatography over a 12 g silica column, using DCM/MeOH (3.5 M NH3) as eluents. This yielded impure intermediate (173 mg). The crude intermediate was dissolved in MeCN (2 mL), before HCl (306 mg, 2.09 mL, 4 molar, 20 Eq, 8.38 mmol) was added. The reaction was stirred for 2 hours, and then the solvent removed to give a yellow solid (251 mg). This was purified by reverse phase chromatography to give pure 20H as an orange-yellow powder (50 mg, 0.082 mmol, 20% yield, 99.2% purity). EXAMPLES - BIOLOGICAL STUDIES Experimental methodology Antitumor activity against a panel of cancer cell lines Antitumor activity of the compounds and doxorubicin as a positive control was assessed by using the CellTiter‐Glow® Luminescent Cell Viability assay (Promega # G7572) according to the manufacturer’s instructions. The compounds were tested at 5 or 6 concentrations in half-log increments (highest concentration 30 µM - 50 µM) in duplicate or triplicate well conditions. Tumor cells were grown at 37°C in a humidified atmosphere with 5% CO2 in RPMI 1640 or DMEM medium, supplemented with 10% (v/v) fetal calf serum and 50 µg/ml gentamicin for up to 20 passages, and were passaged once or twice weekly. Cells were harvested using TrypLE or PBS buffer containing 1 mM EDTA, and the percentage of viable cells is determined using a cell counter. Cells were harvested from exponential phase cultures, counted and plated in 96 well flat-bottom microtiter plates at a cell density depending on the cell line’s growth rate (4,000 - 20,000 cells/well depending on the cell line’s growth rate, up to 60,000 for hematological cancer cell lines) in RPMI 1640 or DMEM medium supplemented with 10% (v/v) fetal calf serum and 50 µg/ml gentamicin (140 µl/well). Cultures were incubated at 37°C and 5% CO2 in a humidified atmosphere. After 24 h, 10 µl of test compounds or control medium are added, and left on the cells for another 72 h. Compounds were serially diluted in DMSO, transferred in cell culture medium, and added to the assay plates. The DMSO concentration was kept constant at < 0.3% v/v across the assay plate. Viability of cells was quantified by the CellTiter‐Glow® Luminescent Cell Viability assay (Promega # G7572). Luminescence was measured with the microplate luminometer (EnVision Perkin Elmer). Sigmoidal concentration-response curves were fitted to the data points (test-versus- control, T/C values) obtained for each tumor model using GraphPad prism 5.02 software. IC50 values are reported as absolute IC50 values, being the concentration of test compound at the intersection of the concentration-response curves with T/C = 50% Cell lines tested are presented in Table 1. Table 1. Tumour cell lines type and designation Example 1. Activity against brain carcinomas SND351, SND352 and SND353 inhibited brain cancer cell growth with IC50s below 10 µM, as presented in Table 2A-C. Table 2A. IC50 values against brain carcinoma cell lines Table 2B. IC50 values against brain carcinoma cell lines Table 2C. IC50 values against brain carcinoma cell lines Example 2. Activity against breast carcinomas SND351 inhibited breast cancer cell growth with IC50s below 10 µM, as presented in Table 3. Table 3. IC50 values against breast carcinoma cell lines Example 3. Activity against colon carcinomas SND351 inhibited colon cancer cell growth with IC50s below 5 µM, as presented in Table 4. Table 4. IC50 values against colon cancer cell line Example 4. Activity against leukaemia SND351 and SND352 inhibited leukaemia cell growth with IC50 below 5 µM, as presented in Table 5A and 5B. Table 5A. IC50 values against acute promyelocytic leukemia cell line Table 5B. IC50 values against myeloid leukemia cell line Example 5. Activity against lung carcinomas SND352 and SND353 inhibited lung carcinoma cell growth with IC50s below 10 µM, as presented in Table 6A - B. Table 6A. IC50 values against lung carcinoma cell lines Table 6B. IC50 values against lung carcinoma cell line Example 6. Activity against skin cancer (melanoma) SND351, SND352 and SND354 inhibited melanoma cell lines growth with IC50s below 10 µM as presented in Table 7A - C. Table 7A. IC50 values against melanoma cell lines Table 7B. IC50 values against melanoma cell lines Table 7C. IC50 values against melanoma cell lines It will be understood that the present invention has been described above by way of example only. The examples are not intended to limit the scope of the invention. Various modifications and embodiments can be made without departing from the scope and spirit of the invention, which is defined by the following claims only.