Title:
FLAVONE DERIVATIVE, PREPARATION METHOD THEREFOR, APPLICATION THEREOF, AND SKIN WHITENING PRODUCT COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2021/008170
Kind Code:
A1
Abstract:
The present application provides a flavone derivative, a preparation method therefor, an application thereof, and a skin whitening product comprising same. The flavone derivative is a compound having a structure represented by formula I or a formula II. The flavone derivative is prepared by taking flavonoid compounds and phenylacetaldehyde compounds as raw materials for reaction in an organic solvent under an acid environment. According to the present application, by modifying the flavonoid compounds with styryl, the obtained flavone derivatives can significantly inhibit melanogenesis and resist oxidation, have a better effect than unmodified flavonoid compounds and α-arbutin commonly available on the market, and thus can be used for preparing products such as skin care products, cosmetics, drugs, health care products or foods for skin whitening.
More Like This:
| WO/1992/002514 | NOVEL BENZOPYRAN DERIVATIVE |
| WO/2023/225204 | METHOD FOR TREATING CANCER |
| JPS63162685 | PRODUCTION OF PROANTHOCYANIDIN |
Inventors:
WANG JUN (CN)
WANG ZIHAO (CN)
LI ZHOUFANG (CN)
WANG ZIHAO (CN)
LI ZHOUFANG (CN)
Application Number:
PCT/CN2020/082047
Publication Date:
January 21, 2021
Filing Date:
March 30, 2020
Export Citation:
Assignee:
UNIV SOUTHERN SCI & TECH (CN)
International Classes:
C07D311/62; A61K8/49; A61P17/16
Foreign References:
| CN109069473A | 2018-12-21 | |||
| EP2202237A1 | 2010-06-30 | |||
| CN110305098A | 2019-10-08 |
Other References:
QIN, ZHU ET AL.: "Inhibitory effects of selected dietary flavonoids on the formation of total heterocyclic amines and 2-amino-1-methyl-6 phenylimidazo [4, 5-b] pyridine (PhIP) in roast beef patties and in chemical models,", FOOD FUNCT., vol. 7, 4 January 2016 (2016-01-04), XP055774162, DOI: 20200601153351X
CHENG, KAWING ET AL.: "Inhibition of mutagenic PhIP formation by epigallocatechin gallate via scavenging of phenylacetaldehyde,", MOL. NUTR. FOOD RES., vol. 53, 9 June 2009 (2009-06-09), XP055774167, DOI: 20200601155139X
CHENG, KAWING ET AL.: "Inhibition of mutagenic PhIP formation by epigallocatechin gallate via scavenging of phenylacetaldehyde,", MOL. NUTR. FOOD RES., vol. 53, 9 June 2009 (2009-06-09), XP055774167, DOI: 20200601155139X
Attorney, Agent or Firm:
BEYOND ATTORNEYS AT LAW (CN)
Download PDF: