Title:
FLEXIBLE MEMBRANE VALVE FOR CELL CULTURE VESSEL
Document Type and Number:
WIPO Patent Application WO/2009/128892
Kind Code:
A3
Abstract:
An assembly for culturing cells includes a housing defining a reservoir for containing cell culture media and an opening in fluid communication with the reservoir. The cell culture assembly further includes a filter valve assembly configured to sealingly engage the opening. The filter valve assembly includes a flexible membrane, a contiguous side wall, an end wall, and a microbial filter. The end wall has an opening and extends across one end of the side wall to form a major cavity within the side wall and the end wall. The flexible membrane has a slit spanning the membrane and is disposable within the major cavity such that the membrane sealingly divides the major cavity into (i) a chamber formed between the end wall and the membrane and (ii) a minor cavity formed by the membrane and a portion of the side wall. The minor cavity is in fluid communication with the reservoir. The slit is biased in a closed position to prevent fluid from passing from the minor cavity into the chamber and is configured to open to allow gas to pass from the minor cavity into the chamber when the pressure differential across the membrane is above a threshold. The filter is disposed between the membrane and the opening such that air flowing through the opening in the end wall into the chamber passes through the filter.
Inventors:
CATTADORIS HENRY J (US)
MARTIN GREGORY R (US)
TANNER ALLISON J (US)
MARTIN GREGORY R (US)
TANNER ALLISON J (US)
Application Number:
PCT/US2009/002302
Publication Date:
December 29, 2011
Filing Date:
April 14, 2009
Export Citation:
Assignee:
CORNING INC (US)
CATTADORIS HENRY J (US)
MARTIN GREGORY R (US)
TANNER ALLISON J (US)
CATTADORIS HENRY J (US)
MARTIN GREGORY R (US)
TANNER ALLISON J (US)
International Classes:
C12M1/22; C12M1/12; C12M1/24
Domestic Patent References:
| WO1988001605A1 | 1988-03-10 |
Foreign References:
| EP1514919A1 | 2005-03-16 | |||
| FR2677664A1 | 1992-12-18 | |||
| US20020039785A1 | 2002-04-04 | |||
| DE2541000B1 | 1976-11-11 | |||
| US4839292A | 1989-06-13 |
Attorney, Agent or Firm:
WILKS, Susan, S. (Intellectual Property DepartmentSp-ti-3-, Corning NY, US)
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