Title:
FLUORESCENT PROBE FOR USE IN DETECTION OF BRAIN TUMOR
Document Type and Number:
WIPO Patent Application WO/2020/235567
Kind Code:
A1
Abstract:
[Problem] To provide a novel fluorescent probe which can be used in a spray mode, has excellent specificity to sensitivity, also has immediacy, and enables the detection of brain tumor. [Solution] A fluorescent probe for use in the detection of brain tumor, which comprises a compound represented by formula (I) or a salt thereof: (in the formula, P1 represents an arginine residue, a histidine residue or a tyrosine residue, and P2 represents a proline residue or a glycine residue, wherein P1 is liked to an adjacent N atom to form an amide bond, and P2 is linked to P1 to form an amide bond; R1 represents 1 to 4 same or different substituents independently selected from the group consisting of a hydrogen atom and an alkyl group, a carboxyl group, an ester group, an alkoxy group, an amide group and an azide group each of which may be substituted; R2, R3, R4, R5, R6 and R7 independently represent a hydrogen atom, a hydroxyl group, an alkyl group which may be substituted, or a halogen atom; R8 and R9 independently represent a hydrogen atom or an alkyl group; X represents O, Si(Ra)(Rb), Ge(Ra)(Rb), Sn(Ra)(Rb), C(Ra)(Rb) or P(=O)(Ra)； Ra and Rb independently represent a hydrogen atom, an alkyl group or an aryl group; and Y represents a C1-C3 alkylene group).
Inventors:
KITAGAWA YOSUKE (JP)
TANAKA SHOTA (JP)
SAITO NOBUHITO (JP)
KURIKI YUGO (JP)
KAMIYA MAKO (JP)
URANO YASUTERU (JP)
TANAKA SHOTA (JP)
SAITO NOBUHITO (JP)
KURIKI YUGO (JP)
KAMIYA MAKO (JP)
URANO YASUTERU (JP)
Application Number:
PCT/JP2020/019814
Publication Date:
November 26, 2020
Filing Date:
May 19, 2020
Export Citation:
Assignee:
UNIV TOKYO (JP)
International Classes:
C07K5/06; C07K5/062; C07K5/078; C09B11/28; C12Q1/37; G01N21/64; G01N21/78; G01N33/48
Domestic Patent References:
| WO2016006678A1 | 2016-01-14 | |||
| WO2013180181A1 | 2013-12-05 | |||
| WO2016006678A1 | 2016-01-14 |
Foreign References:
| US20060241057A1 | 2006-10-26 | |||
| JP2016527284A | 2016-09-08 | |||
| JP2010240188A | 2010-10-28 | |||
| JP2015023904A | 2015-02-05 |
Other References:
SHOTA TANAKA, YOSUKE KITAGAWA, AKIRA OGASAWARA, YUGO KURIKI, KYOKO YAMAMOTO, MAKO KAMIYA AND YASUTERU URANO: "SURG-11. PATHOLOGICAL INVESTIGATION OF NOVEL SPRAY-TYPE FLUORESCENT PROBES FOR BRAIN TUMORS", NEURO-ONCOLOGY, vol. 20, no. supply 6, 2018, pages vi252 - vi253, XP055762813, ISSN: 1522- 8517
COBURGER ET AL., NEUROSURGICAL FOCUS, vol. 36, no. 2, 2014, pages E3
FERRARO ET AL., NEUROSURGICAL REVIEW, vol. 39, no. 4, 2016, pages 545 - 555
See also references of EP 3974438A4
COBURGER ET AL., NEUROSURGICAL FOCUS, vol. 36, no. 2, 2014, pages E3
FERRARO ET AL., NEUROSURGICAL REVIEW, vol. 39, no. 4, 2016, pages 545 - 555
See also references of EP 3974438A4
Attorney, Agent or Firm:
ONO Makoto et al. (JP)
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