Title:
FLUORESCENT PROBES
Document Type and Number:
WIPO Patent Application WO/2022/270607
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a fluorescent probe that detects calpain enzymatic activity with high sensitivity. This invention increases the enzymatic reactivity with calpain by bonding an amino group which has an α carbon bonded to an oxygen atom, to the N terminal of a peptide chain. In comparison with conventionally reported HMRG fluorescent probes, this probe has improved reactivity with calpain, so a fluorescent probe is provided which that detects calpain activity with higher sensitivity. Specifically, the present invention relates to the compound represented in general formula (I) or a salt thereof.
Inventors:
NAKAZAWA TORU (JP)
SUZUKI YUKI (JP)
OKA TAKAYUKI (JP)
UCHIDA TAKATOSHI (JP)
SUZUKI YUKI (JP)
OKA TAKAYUKI (JP)
UCHIDA TAKATOSHI (JP)
Application Number:
PCT/JP2022/025205
Publication Date:
December 29, 2022
Filing Date:
June 23, 2022
Export Citation:
Assignee:
TOHOKU TECHNO ARCH CO LTD (JP)
GORYO CHEMICAL INC (JP)
SENJU PHARMA CO (JP)
GORYO CHEMICAL INC (JP)
SENJU PHARMA CO (JP)
International Classes:
C07K5/062; A61K49/00; C12Q1/02; C12Q1/37; G01N33/68
Domestic Patent References:
| WO2016137004A1 | 2016-09-01 | |||
| WO2014136780A1 | 2014-09-12 |
Foreign References:
| JP2004520850A | 2004-07-15 | |||
| JP2014505685A | 2014-03-06 |
Other References:
THE JOURNAL OF BIOLOGICACLH, vol. 268, 1993, pages 23593 - 23600
STEM CELLS TR_ANSL MED, vol. 6, no. 677275-28-4, 2017, pages 1972 - 1986
METHODS CELL BIOL, vol. 159, 2020, pages 279 - 302
STEM CELLS TR_ANSL MED, vol. 6, no. 677275-28-4, 2017, pages 1972 - 1986
METHODS CELL BIOL, vol. 159, 2020, pages 279 - 302
Attorney, Agent or Firm:
MOMII Takafumi (JP)
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