Title:
FLUORINATED EMPATHOGENS
Document Type and Number:
WIPO Patent Application WO/2023/028092
Kind Code:
A3
Abstract:
Provided are fluorinated analogs of MDMA, including fluorinated empathogens. In some embodiments, such compounds are monoamine releasers or inhibit monoamine transporters. In some aspects, features of the compounds provide stability, such as metabolic stability, and efficacy. Also provided are methods for the preparation of fluorinated empathogens and pharmaceutical compositions comprising the same. Methods of using the fluorinated empathogens, alone or in combination with other therapeutic agents, are provided. In some embodiments, fluorinated empathogens are used to treat CNS disorders, such as mental health conditions and neurodegenerative disorders.
Inventors:
COZZI NICHOLAS (US)
DALEY PAUL (US)
DALEY PAUL (US)
Application Number:
PCT/US2022/041283
Publication Date:
April 06, 2023
Filing Date:
August 23, 2022
Export Citation:
Assignee:
ALEXANDER SHULGIN RES INSTITUTE (US)
International Classes:
A61K31/135; A61K31/137
Domestic Patent References:
| WO1998026775A1 | 1998-06-25 |
Foreign References:
| US20080045588A1 | 2008-02-21 | |||
| US20200390746A1 | 2020-12-17 | |||
| US20170174614A1 | 2017-06-22 |
Other References:
DATABASE CID ANONYMOUS : "N-[2-(1,3-benzodioxol-5-yl)ethyl]-2,2,2-trifluoroethanamine", XP093060744
DATABASE PubChem PUBCHEM : "2-(3,4-dimethoxyphenyl)-N-(trifluoromethyl)ethanamine | C11H14F3NO2 |", XP093060747, retrieved from STN
DATABASE PUBHCEM COMPOUND ANONYMOUS : "Homarylamine ", XP093040578, retrieved from PUBCHEM
DATABASE PubChem STN; PUBCHEM : "3,4-MDMA-d3 (hydrochloride) | C11H16ClNO2 ", XP093060753
DATABASE PUBCHEM COMPOUND ANONYMOUS : "MDE-d5 Hydrochloride", XP093040565, retrieved from PUBCHEM
DATABASE PUBCHEM COMPOUND ANONYMOUS : "Butylone-d3 (hydrochloride)", XP093040571, retrieved from PUBCHEM
DATABASE PubChem PUBCHEM : "N-[2-(3,4-dimethoxyphenyl)ethyl]-2,2,2-trifluoroethanamine | C12H16F3NO2", XP093060766, retrieved from STN
DATABASE PubChem PUBCHEM : "1-(1,3-Benzodioxol-5-yl)-2-[methyl(2,2,2-trifluoroethyl)amino]ethanone | C12H12F3NO3 ", XP093060769, retrieved from STN
DATABASE PubChem PUBCHEM : "1-(3,4-Dimethoxyphenyl)-2-(2,2,2-trifluoroethylamino)ethanone | C12H14F3NO3 ", XP093060777, retrieved from STN
DATABASE PubChem PUBCHEM : "2-(3,4-dimethoxyphenyl)-N-(trifluoromethyl)ethanamine | C11H14F3NO2 |", XP093060747, retrieved from STN
DATABASE PUBHCEM COMPOUND ANONYMOUS : "Homarylamine ", XP093040578, retrieved from PUBCHEM
DATABASE PubChem STN; PUBCHEM : "3,4-MDMA-d3 (hydrochloride) | C11H16ClNO2 ", XP093060753
DATABASE PUBCHEM COMPOUND ANONYMOUS : "MDE-d5 Hydrochloride", XP093040565, retrieved from PUBCHEM
DATABASE PUBCHEM COMPOUND ANONYMOUS : "Butylone-d3 (hydrochloride)", XP093040571, retrieved from PUBCHEM
DATABASE PubChem PUBCHEM : "N-[2-(3,4-dimethoxyphenyl)ethyl]-2,2,2-trifluoroethanamine | C12H16F3NO2", XP093060766, retrieved from STN
DATABASE PubChem PUBCHEM : "1-(1,3-Benzodioxol-5-yl)-2-[methyl(2,2,2-trifluoroethyl)amino]ethanone | C12H12F3NO3 ", XP093060769, retrieved from STN
DATABASE PubChem PUBCHEM : "1-(3,4-Dimethoxyphenyl)-2-(2,2,2-trifluoroethylamino)ethanone | C12H14F3NO3 ", XP093060777, retrieved from STN
Attorney, Agent or Firm:
PECHENIK, Graham (US)
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