Title:
FLUORINE-CONTAINING GRAPHENE QUANTUM DOT, APPLICATION THEREOF AS PHOTOSENSITIZER FOR PHOTODYNAMIC THERAPY, AND PREPARATION METHOD
Document Type and Number:
WIPO Patent Application WO/2021/046966
Kind Code:
A1
Abstract:
A fluorine-containing graphene quantum dot, an application thereof as a photosensitizer for photodynamic therapy, and a preparation method, belonging to the field of biomedical materials. The prepared fluorine-containing graphene quantum dot, on average, has a thickness of 1.0-3.0 nm, a size of 2.0-3.0 nm, a fluorine content of 1%-2%, an oxygen content of 20%-30%, and a carbon content of 60%-70%. The present fluorine-containing graphene quantum dot is smaller in size and morphologically uniform, has a stable structure, and has a high generation rate of singlet oxygen under visible light irradiation. Also, said quantum dot has extremely low cytotoxicity, good water solubility, and more exceptional biocompatibility, being an ideal photosensitizer for photodynamic therapy, and suitable for early treatment procedures for diseases such as esophageal cancer, skin cancer, and lung cancer, and possessing a wide range of application prospects.
Inventors:
BI HONG (CN)
LI ZHENZHEN (CN)
TEDESCO ANTONIO CLAUDIO (CN)
LI ZHENZHEN (CN)
TEDESCO ANTONIO CLAUDIO (CN)
Application Number:
PCT/CN2019/111622
Publication Date:
March 18, 2021
Filing Date:
October 17, 2019
Export Citation:
Assignee:
UNIV ANHUI (CN)
International Classes:
C01B32/184; A61P35/00; C01B32/19; C01B32/198
Domestic Patent References:
| WO2012083534A1 | 2012-06-28 |
Foreign References:
| CN108545729A | 2018-09-18 | |||
| CN105460920A | 2016-04-06 | |||
| CN108423655A | 2018-08-21 |
Other References:
GONG PEIWEI; YANG ZHIGANG; HONG WEI; WANG ZHAOFENG; HOU KAIMING; WANG JINQING; YANG SHENGRONG: "To lose is to gain: Effective synthesis of water-soluble graphene fluoroxide quantum dots by sacrificing certain fluorine atoms from exfoliated fluorinated graphene", CARBON, ELSEVIER OXFORD, GB, vol. 83, 24 November 2014 (2014-11-24), GB, pages 152 - 161, XP029115883, ISSN: 0008-6223, DOI: 10.1016/j.carbon.2014.11.027
GONG PEIWEI; YANG ZHIGANG; HONG WEI; WANG ZHAOFENG; HOU KAIMING; WANG JINQING; YANG SHENGRONG: "To lose is to gain: Effective synthesis of water-soluble graphene fluoroxide quantum dots by sacrificing certain fluorine atoms from exfoliated fluorinated graphene", CARBON, ELSEVIER OXFORD, GB, vol. 83, 24 November 2014 (2014-11-24), GB, pages 152 - 161, XP029115883, ISSN: 0008-6223, DOI: 10.1016/j.carbon.2014.11.027
LI, XINCONG, ＭIAOＬEＩＹＩＮＧ: "Advances in the Research of Graphene Quantum Dots in Biomedica Science", MATERIALS REVIEW, vol. 32, 31 May 2018 (2018-05-31), pages 176 - 182, XP055790182
GONG PEIWEI; YANG ZHIGANG; HONG WEI; WANG ZHAOFENG; HOU KAIMING; WANG JINQING; YANG SHENGRONG: "To lose is to gain: Effective synthesis of water-soluble graphene fluoroxide quantum dots by sacrificing certain fluorine atoms from exfoliated fluorinated graphene", CARBON, ELSEVIER OXFORD, GB, vol. 83, 24 November 2014 (2014-11-24), GB, pages 152 - 161, XP029115883, ISSN: 0008-6223, DOI: 10.1016/j.carbon.2014.11.027
LI, XINCONG, ＭIAOＬEＩＹＩＮＧ: "Advances in the Research of Graphene Quantum Dots in Biomedica Science", MATERIALS REVIEW, vol. 32, 31 May 2018 (2018-05-31), pages 176 - 182, XP055790182
Attorney, Agent or Firm:
HEFEI GUOHE PATENT AGENCY (GENERAL PARTNERSHIP) (CN)
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