Title:
FLUOROGENIC SUBSTRATES FOR AMINOPEPTIDASE DETECTION IN BIOFLUIDS
Document Type and Number:
WIPO Patent Application WO/2023/172648
Kind Code:
A3
Abstract:
The present application provides compositions and methods for determining a disease or condition in a subject. The method comprises contacting a body fluid with a molecule comprising a reporter thereof and the reported is cleaved by an agent in the body fluid. Diseases and conditions that can be determined by the methods are also described herein
Inventors:
TOUTI FAYCAL (US)
TORNER JUSTIN MURRAY (US)
MOSE GRACYN SCHEID (US)
TORNER JUSTIN MURRAY (US)
MOSE GRACYN SCHEID (US)
Application Number:
PCT/US2023/014844
Publication Date:
December 07, 2023
Filing Date:
March 08, 2023
Export Citation:
Assignee:
GLYMPSE BIO INC (US)
International Classes:
C12Q1/37; C07K1/13; C07K7/02; C07K7/06; C07K7/08
Domestic Patent References:
| WO2017011820A2 | 2017-01-19 |
Foreign References:
| US20220128567A1 | 2022-04-28 | |||
| US6495357B1 | 2002-12-17 | |||
| US20150038435A1 | 2015-02-05 |
Other References:
SVENSSON BIRTE, SJÖSTRÖM HANS, NORÉN OVE: "Structural Studies on Microvillus Aminopeptidase from Pig Small Intestine", EUROPEAN JOURNAL OF BIOCHEMISTRY, PUBLISHED BY SPRINGER-VERLAG ON BEHALF OF THE FEDERATION OF EUROPEAN BIOCHEMICAL SOCIETIES, vol. 126, no. 3, 1 September 1982 (1982-09-01), pages 481 - 488, XP093118463, ISSN: 0014-2956, DOI: 10.1111/j.1432-1033.1982.tb06805.x
YI LIU;WENJING CUI;YUEQIN FANG;YUECHUN YU;YOUTIAN CUI;YUANYUAN XIA;MICHIHIKO KOBAYASHI;ZHEMIN ZHOU: "Strategy for successful expression of the Pseudomonas putida nitrile hydratase activator P14K in Escherichia coli", BMC BIOTECHNOLOGY, BIOMED CENTRAL LTD, vol. 13, no. 1, 3 June 2013 (2013-06-03), pages 48, XP021152185, ISSN: 1472-6750, DOI: 10.1186/1472-6750-13-48
CHO, YW ET AL.: "Polycation gene delivery systems: escape from endosomes to cytosol", JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 55, 6 June 2003 (2003-06-06), pages 721 - 734, XP007914500, DOI: 10.1211/002235703765951311
YI LIU;WENJING CUI;YUEQIN FANG;YUECHUN YU;YOUTIAN CUI;YUANYUAN XIA;MICHIHIKO KOBAYASHI;ZHEMIN ZHOU: "Strategy for successful expression of the Pseudomonas putida nitrile hydratase activator P14K in Escherichia coli", BMC BIOTECHNOLOGY, BIOMED CENTRAL LTD, vol. 13, no. 1, 3 June 2013 (2013-06-03), pages 48, XP021152185, ISSN: 1472-6750, DOI: 10.1186/1472-6750-13-48
CHO, YW ET AL.: "Polycation gene delivery systems: escape from endosomes to cytosol", JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 55, 6 June 2003 (2003-06-06), pages 721 - 734, XP007914500, DOI: 10.1211/002235703765951311
Attorney, Agent or Firm:
SERAFINI, Andrew T. et al. (US)
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