Title:
FLUOROSULFONYL FREE RADICAL REAGENT, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/252404
Kind Code:
A1
Abstract:
Provided in the present invention are a fluorosulfonyl free radical reagent, and a preparation method therefor and the use thereof, belonging to the technical field of organic synthesis. The fluorosulfonyl free radical reagent provided by the present invention can efficiently generate fluorosulfonyl free radicals and results in a corresponding free radical reaction, and the product yield is high. Moreover, the fluorosulfonyl free radical reagent provided by the present invention is applicable to an extremely wide range of substrates, and can be reacted with various types of olefin substrates and alkyne substrates to efficiently synthesize fluorosulfonylation products. Furthermore, the fluorosulfonyl free radical reagent provided by the present invention is in a stable solid state at room temperature, is non-volatile, low in toxicity, easy to store and convenient to use, and has important academic and application values. In addition, the present invention provides a preparation method for the fluorosulfonyl free radical reagent. The preparation method is easy to operate and suitable for large-scale production.
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Inventors:
LIAO SAIHU (CN)
WANG PENG (CN)
ZHANG HONGHAI (CN)
WANG PENG (CN)
ZHANG HONGHAI (CN)
Application Number:
PCT/CN2021/113240
Publication Date:
December 08, 2022
Filing Date:
August 18, 2021
Export Citation:
Assignee:
UNIV FUZHOU (CN)
International Classes:
C07D235/22; C07B45/00; C07C303/02; C07C303/32; C07C309/06; C07C309/81; C07C309/84; C07D209/48; C07D233/58; C07D235/10
Domestic Patent References:
| WO2019101132A1 | 2019-05-31 |
Foreign References:
| CN110590609A | 2019-12-20 | |||
| CN106659700A | 2017-05-10 | |||
| CN110589783A | 2019-12-20 | |||
| CN107857730A | 2018-03-30 | |||
| CN112174855A | 2021-01-05 | |||
| CN113248444A | 2021-08-13 |
Other References:
GUO, TAIJIE ET AL.: "A New Portal to SuFEx Click Chemistry: A Stable Fluorosulfuryl Imidazolium Salt Emerging as an “F-SO2+” Donor of Unprecedented Reactivity, Selectivity, and Scope", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 57, 1 February 2018 (2018-02-01), pages 2605 - 2610, XP055538567, DOI: 10.1002/anie.201712429
Attorney, Agent or Firm:
BEIJING FINELAND IP FIRM (CN)
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