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Title:
FN3 DOMAIN-SIRNA CONJUGATES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/076574
Kind Code:
A3
Abstract:
The present disclosure relates to compositions, such as siRNA molecules and FN3 domains conjugated to the same, as well as methods of making and using the molecules. In some embodiments, siRNA conjugated to FN3 domains that bind CD71 protein are provided. In some embodiments, siRNA conjugated to FN3 domains that bind EPCAM protein are provided. In some embodiments, siRNA conjugated to FN3 domains that bind ECFR protein are provided.

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Inventors:
ADDIS RUSSELL C (US)
DRUZINA ZHANNA (US)
KOLAKOWSKI ROBERT (US)
KULKARNI SWAPNIL (US)
NADLER STEVEN G (US)
O'NEIL KARYN (US)
XIN YAO (US)
Application Number:
PCT/US2020/055509
Publication Date:
May 14, 2021
Filing Date:
October 14, 2020
Export Citation:
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Assignee:
ARO BIOTHERAPEUTICS COMPANY (US)
International Classes:
A61K47/64; A61K31/7105; A61K47/68; A61K47/69; A61P35/00; B82Y5/00
Domestic Patent References:
WO2010115202A22010-10-07
WO2005018534A22005-03-03
WO2005042708A22005-05-12
Foreign References:
US20190184028A12019-06-20
US20150005364A12015-01-01
Attorney, Agent or Firm:
SCOLNICK, Daniel M. (US)
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