Title:
FORMULATION FOR DELIVERY OF LUBRICIN GENE
Document Type and Number:
WIPO Patent Application WO/2021/086973
Kind Code:
A3
Abstract:
Compositions comprising nanoparticles, nanoplexes or virus comprising isolated nucleic acid comprising nucleic acid encoding a mammalian, and methods of using the compositions, are provided.
Inventors:
SALEM ALIASGER (US)
MARTIN JAMES (US)
CHAKKA LEELA (US)
QUARTERMAN JULIANA (US)
ZHENG HONGJUN (US)
SEOL DONG RIM (US)
MARTIN JAMES (US)
CHAKKA LEELA (US)
QUARTERMAN JULIANA (US)
ZHENG HONGJUN (US)
SEOL DONG RIM (US)
Application Number:
PCT/US2020/057750
Publication Date:
September 02, 2021
Filing Date:
October 28, 2020
Export Citation:
Assignee:
UNIV IOWA RES FOUND (US)
International Classes:
A61K48/00; C07K14/47; C12N15/86
Domestic Patent References:
| WO2018067545A1 | 2018-04-12 |
Foreign References:
| US20130123314A1 | 2013-05-16 |
Other References:
MARTIN JAMES A: "Intra-Articular Lubricin Gene Therepy for Post-Traumatic Arthritis", 1 September 2015 (2015-09-01), XP055809659, Retrieved from the Internet [retrieved on 20210601]
M. Z. C. RUAN ET AL: "Proteoglycan 4 Expression Protects Against the Development of Osteoarthritis", SCIENCE TRANSLATIONAL MEDICINE, vol. 5, no. 176, 13 March 2013 (2013-03-13), pages 176ra34 - 176ra34, XP055117117, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.3005409
KRISHNAN YAMINI ET AL: "Cartilage diseases", MATRIX BIOLOGY, vol. 71-72, 1 October 2018 (2018-10-01), NL, pages 51 - 69, XP055810735, ISSN: 0945-053X, DOI: 10.1016/j.matbio.2018.05.005
KIM JIN-HONG ET AL: "Matrix cross-linking-mediated mechanotransduction promotes posttraumatic osteoarthritis", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 112, no. 30, 28 July 2015 (2015-07-28), pages 9424 - 9429, XP055810814, ISSN: 0027-8424, Retrieved from the Internet DOI: 10.1073/pnas.1505700112
ANA REY-RICO ET AL: "PEO-PPO-PEO Carriers for rAAV-Mediated Transduction of Human Articular Chondrocytes in Vitro and in a Human Osteochondral Defect Model", APPLIED MATERIALS & INTERFACES, vol. 8, no. 32, 3 August 2016 (2016-08-03), US, pages 20600 - 20613, XP055561294, ISSN: 1944-8244, DOI: 10.1021/acsami.6b06509
M. Z. C. RUAN ET AL: "Proteoglycan 4 Expression Protects Against the Development of Osteoarthritis", SCIENCE TRANSLATIONAL MEDICINE, vol. 5, no. 176, 13 March 2013 (2013-03-13), pages 176ra34 - 176ra34, XP055117117, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.3005409
KRISHNAN YAMINI ET AL: "Cartilage diseases", MATRIX BIOLOGY, vol. 71-72, 1 October 2018 (2018-10-01), NL, pages 51 - 69, XP055810735, ISSN: 0945-053X, DOI: 10.1016/j.matbio.2018.05.005
KIM JIN-HONG ET AL: "Matrix cross-linking-mediated mechanotransduction promotes posttraumatic osteoarthritis", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 112, no. 30, 28 July 2015 (2015-07-28), pages 9424 - 9429, XP055810814, ISSN: 0027-8424, Retrieved from the Internet
ANA REY-RICO ET AL: "PEO-PPO-PEO Carriers for rAAV-Mediated Transduction of Human Articular Chondrocytes in Vitro and in a Human Osteochondral Defect Model", APPLIED MATERIALS & INTERFACES, vol. 8, no. 32, 3 August 2016 (2016-08-03), US, pages 20600 - 20613, XP055561294, ISSN: 1944-8244, DOI: 10.1021/acsami.6b06509
Attorney, Agent or Firm:
PERDOK, Monique, M. et al. (US)
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