Title:
FORMULATIONS OF HUMAN PARATHYROID HORMONE (PTH) AND METHODS FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2021/195877
Kind Code:
A1
Abstract:
Stable liquid pharmaceutical formulations comprising human parathyroid hormone are provided herein. In various embodiments, the stable liquid pharmaceutical formulations comprise human parathyroid hormone (huPTH); a buffering agent to maintain the pH range of the solution from 3 to 6; one or more stabilizing agents selected from the group consisting of sugars, salts, surfactants, proteins, chaotropic agents, lipids, and amino acids; a tonicity modifier; water; and optionally a parenterally acceptable preservative; and wherein said solution is sterile and ready for parenteral administration to a human patient.
Inventors:
WANG HUAN (CN)
SHI LEI (CN)
LI XIAOWEN (CN)
ZHANG LINHONG (CN)
GUO XIANG (CN)
YANG CHUN (CN)
LI TIANSHENG (US)
SHI LEI (CN)
LI XIAOWEN (CN)
ZHANG LINHONG (CN)
GUO XIANG (CN)
YANG CHUN (CN)
LI TIANSHENG (US)
Application Number:
PCT/CN2020/082163
Publication Date:
October 07, 2021
Filing Date:
March 30, 2020
Export Citation:
Assignee:
SICHUAN LUZHOU BUCHANG BIO PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K38/29; A61K47/10; A61K47/12; A61K47/18; A61K47/26
Foreign References:
| EP2052736A1 | 2009-04-29 | |||
| CN1342087A | 2002-03-27 | |||
| CN1170361A | 1998-01-14 | |||
| CN1281370A | 2001-01-24 | |||
| CN1142772A | 1997-02-12 | |||
| US5563122A | 1996-10-08 | |||
| US5208041A | 1993-05-04 | |||
| US4086196A | 1978-04-25 |
Other References:
CUSANO NE ET AL., J CLIN ENDOCRINOL METAB., vol. 98, 2013, pages 137 - 144
"Remington: The Science and Practice of Pharmacy", 2012, PHARMACEUTICAL PRESS
"Remington: The Science and Practice of Pharmacy", 2012, PHARMACEUTICAL PRESS
Attorney, Agent or Firm:
AFD CHINA INTELLECTUAL PROPERTY LAW OFFICE (CN)
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