Title:
FREEZE-DRIED COLLAGEN-SPONGE-TYPE COMPOSITION FOR BONE REGENERATION
Document Type and Number:
WIPO Patent Application WO/2022/092515
Kind Code:
A1
Abstract:
The present invention relates to a collagen-sponge-type composition for bone regeneration, prepared by homogenizing hydrated collagen and a mixed solution of lidocaine, epinephrine and thrombin, and then freeze drying same. The composition according to the present invention activates undifferentiated cells in bone marrow and activates a bone regeneration ability in bone marrow through the activation and differentiation of osteoclasts and osteoblasts, and can be a successful treatment method for medication-related osteonecrosis of the jaws (MRONJ) through a myeloid activation treatment method, uses various growth factors and myeloid activation factors such as cytokines for future myeloid activation to allow for the development of treatment for the fundamental cause of MRONJ through the myeloid activation treatment method, and enables the complete regeneration of aesthetic and functional jaw bone conditions, and thus can be effectively used in the treatment of various diseases caused by bone remodeling failure.
Inventors:
KWON KYUNG HWAN (KR)
Application Number:
PCT/KR2021/011352
Publication Date:
May 05, 2022
Filing Date:
August 25, 2021
Export Citation:
Assignee:
DENHOUSE CO LTD (KR)
International Classes:
A61L27/24; A61C8/02; A61L27/54; A61L27/56
Foreign References:
| KR20140090481A | 2014-07-17 | |||
| US4515637A | 1985-05-07 | |||
| KR20190092059A | 2019-08-07 | |||
| JP2003055237A | 2003-02-26 | |||
| KR102273121B1 | 2021-07-06 |
Other References:
SIVAGURUNATHAN, S. ET AL.: "Thrombin inhibits osteoclast differentiation through a non-proteolytic mechanism", JOURNAL OF MOLECULAR ENDOCRINOLOGY, vol. 50, no. 3, 2013, pages 347 - 359, XP055882870, Retrieved from the Internet DOI: 10.1530/JME-12-0177
Attorney, Agent or Firm:
JUNG, Yeo Soon (KR)
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