Title:
FROZEN AND FREEZE-DRIED MITOCHONDRIA AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/191495
Kind Code:
A1
Abstract:
The present invention relates to a method of freezing and/or freeze-drying mitochondria isolated from cells, and a use of frozen and/or freeze-dried mitochondria. The frozen mitochondria according to the present invention showed similarity to non-frozen mitochondria in terms of anti-inflammatory activity and activity of energy metabolism-related enzymes. Also, freeze-dried mitochondria showed similar levels of anti-inflammatory activity, activity of energy metabolism-related enzymes, and long-term preservation efficacy after recovery to those in the mitochondria before freeze-drying. Therefore, allowing isolated mitochondria to find a wide spectrum of applications in the therapy of various disorders caused by mitochondrial dysfunction or impairment, the frozen and/or freeze-dried mitochondria according to the present invention is expected to greatly enhance the commercial availability of therapeutics containing mitochondria.
Inventors:
KANG YOUNG CHEOL (KR)
HAN KYUBOEM (KR)
KIM CHUN-HYUNG (KR)
KIM SOOMIN (KR)
HAN KYUBOEM (KR)
KIM CHUN-HYUNG (KR)
KIM SOOMIN (KR)
Application Number:
PCT/KR2023/004181
Publication Date:
October 05, 2023
Filing Date:
March 29, 2023
Export Citation:
Assignee:
PAEAN BIOTECHNOLOGY INC (KR)
International Classes:
C12N5/071; A01N1/02; A61K35/12; C12N1/04
Domestic Patent References:
| WO2021015298A1 | 2021-01-28 | |||
| WO2019220654A1 | 2019-11-21 |
Foreign References:
| KR20200035915A | 2020-04-06 | |||
| KR20070069583A | 2007-07-03 | |||
| KR20220037435A | 2022-03-24 |
Attorney, Agent or Firm:
RYU, Jong Woo et al. (KR)
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