FUNCTION REGULATOR FOR RETINOID RELATIVE RECEPTOR - TAKEDA CHEMICAL INDUSTRIES LTD

Title:

FUNCTION REGULATOR FOR RETINOID RELATIVE RECEPTOR

Document Type and Number:

WIPO Patent Application WO/2003/000249

Kind Code:

A1

Abstract:

A function regulator for retinoid relative receptors (excluding retionic acid receptors) which contains a compound represented by the general formula (I) (wherein one of R¹ and R² represents an optionally substituted, monocyclic aromatic hydrocarbon group or an optionally substituted, monocyclic aromatic heterocyclic group containing one heteroatom and the other represents hydrogen, etc.&semi B represents a 5− or 6−membered heterocycle (excluding 1,3−azole)&semi A represents an optionally substituted aromatic hydrocarbon group or an optionally substituted aromatic heterocyclic group&semi and R³ represents hydrogen, etc.) or a salt thereof. The regulator is useful as a preventive&sol remedy for diabetes, hyperlipidemia, impaired glucose tolerance, etc.

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Inventors:

MAEKAWA TSUYOSHI (JP)
KUNITOMO JUN (JP)
ODAKA HIROYUKI (JP)
KIMURA HIROYUKI (JP)

Application Number:

PCT/JP2002/006349

Publication Date:

January 03, 2003

Filing Date:

June 25, 2002

Export Citation:

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Assignee:

TAKEDA CHEMICAL INDUSTRIES LTD (JP)
MAEKAWA TSUYOSHI (JP)
KUNITOMO JUN (JP)
ODAKA HIROYUKI (JP)
KIMURA HIROYUKI (JP)

International Classes:

A61K31/00; A61K31/341; A61K31/381; A61K31/40; A61K31/4196; A61K31/42; A61K31/4245; A61K31/433; A61K31/4418; A61K31/625; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P5/50; A61P43/00; C07D207/337; C07D213/61; C07D249/08; C07D261/08; C07D271/107; C07D307/54; C07D333/24; C07D207/32; C07D271/10; (IPC1-7): A61K31/341; A61K31/381; A61K31/40; A61K31/4196; A61K31/42; A61K31/4245; A61K31/433; A61K31/4418; A61K31/625; A61K45/00; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P5/50; A61P43/00; C07D207/337; C07D307/54; C07D213/61; C07D249/08; C07D261/08; C07D271/06; C07D271/10; C07D285/12; C07D333/24

Domestic Patent References:

WO2000001679A1

2000-01-13

Other References:

BROOKS DAWN A. ET AL.: "Design and synthesis of 2-methyl-2-(2-(5-methyl-2-aryloxazol-4-yl)ethoxy)phenoxy)propionic acids: A new class of dual PPAR alpha/gamma agonists", JOURNAL OF MEDICINAL CHEMISTRY, vol. 44, no. 13, 2001, pages 2061 - 2064, XP002184099
WILLSON TIMOTHY M. ET AL.: "The PPARs: From orphan receptors to drug discovery", JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, no. 4, 2000, pages 527 - 550, XP002956330
See also references of EP 1405636A4

Attorney, Agent or Firm:

Takahashi, Shuichi c/o Osaka Plant of TAKEDA CHEMICAL INDUSTRIES LTD. (17-85, Jusohonmachi 2-chome, Yodogawa-k, Osaka-shi Osaka, JP)

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