Title:
FUNCTIONAL REGULATORY ANTIBODY HAVING ACTIONS OF PROMOTING PROLIFERATION, SURVIVAL, AND CELL ACTIVATION OF DERMAL PAPILLA CELLS AS HAIR GROWTH REGULATING CENTER CELLS AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/082512
Kind Code:
A1
Abstract:
The present invention relates to a functional antibody, which specifically binds to only dermal papilla cells and dermal sheath cells and has efficacies of proliferation, survival, and activation of cells, and to a use thereof and, more specifically, to a pharmaceutical composition/cosmetic composition for preventing hair loss or promoting hair growth using the functional antibody, and to a method for preventing hair loss or promoting hair growth. It was verified that the functional antibody promotes the proliferation, survival, and activation of dermal papilla cells through cell signaling by binding with a receptor protein specifically expressed in only dermal papilla cells, thereby promoting hair growth. Therefore, the present invention can perform target therapy through a more fundamental approach in the prevention or treatment of hair loss, and is expected to also contribute to the production of cell therapeutic agents containing dermal papilla cells.
Inventors:
KIM DONG KU (KR)
Application Number:
PCT/KR2016/007598
Publication Date:
May 18, 2017
Filing Date:
July 13, 2016
Export Citation:
Assignee:
KIM DONG KU (KR)
International Classes:
C07K14/705; A61K8/64; A61K39/395; A61Q9/04; C07K16/28
Foreign References:
| US20020102551A1 | 2002-08-01 | |||
| US20090232778A1 | 2009-09-17 | |||
| US20080213882A1 | 2008-09-04 | |||
| US20130212724A1 | 2013-08-15 |
Other References:
GREC O ET AL.: "A Two-step Mechanism for Stem Cell Activation during Hair Regeneration", CELL STEM CELL, vol. 4, 2009, pages 155 - 169, XP055382193
See also references of EP 3360894A4
See also references of EP 3360894A4
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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