FUNCTIONALIZED FLUOROALKYL SILANE, AND SYNTHETIC METHOD THEREFOR AND APPLICATION THEREOF

WIPO Patent Application WO/2022/095823

A1

Disclosed in the present invention are a functionalized fluoroalkyl silane compound and a synthetic method therefor. The method comprises: dissolving a halosilane and a fluoroalkyl source in an organic solvent; and synthesizing functionalized fluoroalkyl silane under the effect of an alkali or a tertiary phosphine compound. The functionalized fluoroalkyl silane can not only be used for constructing a series of high added-value compounds such as fluoroalkyl substituted alcohols, ketones and amines that can be constructed by conventional TMSR f, but also can transfer, by means of appropriate conversion, a functional group on a silicon protecting group to the obtained addition product in an addition reaction, for synthesizing some fluorine-containing compounds that cannot be synthesized by using a conventional TMSR f reagent, thereby greatly improving the synthesis efficiency and the atom economy of reactions. Also disclosed in the present invention are more excellent reaction efficiency and enantioselectivity, compared with conventional TMSCF 3, exhibited by trifluoromethyl chloromethylsilane in synthesis of a 2-trifluoromethylquinoline compound and in an asymmetric trifluoromethylation reaction with α,β-unsaturated ketones.

ZHOU JIAN (CN)
MU BOSHUAI (CN)
YU JINSHENG (CN)

PCT/CN2021/127919

May 12, 2022

November 01, 2021

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UNIV EAST CHINA NORMAL (CN)

C07F7/08; C07C45/51; C07F7/12; C07F7/14

CN106366108A	2017-02-01
CN108440310A	2018-08-24
CN107473995A	2017-12-15
JPH09143185A	1997-06-03
CN103649263A	2014-03-19

MSJLAW OFFICE (CN)

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