FUNGAL SIGNALLING AND METABOLIC ENZYMES

WIPO Patent Application WO2006059111

A3

Method of identifying an anti-fungal agent which targets as an essential protein or gene of a fungus comprising contacting a candidate substance with (i) a protein which comprises the sequence shown by SEQ ID NOS: 3, 6, 9, 12, 15, 18, 21, 24, 27, 30, 33, 36, 39, 42, 45, 48, 50, 53, 56, 59, 61 or 63, or (ii) a protein which has 60% identity with (i), or (iii) a protein comprising a fragment of (i) or (ii) which fragment has a length of at least 50 amino acids, or (iv) a polynucleotide that comprises a sequence which encodes (i), (ii) or (iii), or (v) a polynucleotide comprising a sequence which has at least 70% identity with the coding sequence of (iv), and determining whether the candidate substance binds or modulates (i), (ii), (iii), (iv), or (v), wherein binding or modulation of (i), (ii), (iii), (iv), or (v) indicates that the candidate substance is an anti-fungal agent.

BROGDEN NINA (GB)
BROMLEY MICHAEL JOHN (GB)
CARR PAUL DAVID (GB)
KAYE SARAH JANE (GB)
OLIVER JASON DAVID (GB)
TUCKWELL DANIEL SCOTT (GB)

PCT/GB2005/004604

August 31, 2006

December 01, 2005

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F2G LTD (GB)
BROGDEN NINA (GB)
BROMLEY MICHAEL JOHN (GB)
CARR PAUL DAVID (GB)
KAYE SARAH JANE (GB)
OLIVER JASON DAVID (GB)
TUCKWELL DANIEL SCOTT (GB)

G01N33/569; C12Q1/20; C12Q1/527; C12Q1/68; G01N33/50

DE10261834A1	2004-07-08
US6465198B1	2002-10-15
US5998420A	1999-12-07

WESTKAEMPER R B ET AL: "SYNTHESIS AND EVALUATION OF 1 HYDROXYCYCLOPROPANECARBOXYLIC ACIDS AS POTENTIAL TRANSITION STATE INHIBITORS OF DIHYDROXY-ACID DEHYDRATASE", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 23, no. 3, 1988, pages 233 - 236, XP002370533, ISSN: 0223-5234

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