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Title:
FUSED HETEROARYL DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF IN MEDICINE
Document Type and Number:
WIPO Patent Application WO/2021/143821
Kind Code:
A1
Abstract:
A fused heteroaryl derivative, a preparation method therefor, and an application thereof in medicine. In particular, provided are a fused heteroaryl derivative as shown in general formula (I-1), a preparation method therefor, a pharmaceutical composition containing the derivative, and a use thereof as a therapeutic agent, particularly as an ATR kinase inhibitor and in the preparation of drugs for the treatment and/or prevention of hyperproliferative diseases. Definitions of each group in the general formula (I-1) are as defined in the description.

Inventors:
LI XIN (CN)
ZENG CHANGGEN (CN)
HE FENG (CN)
TAO WEIKANG (CN)
Application Number:
PCT/CN2021/072090
Publication Date:
July 22, 2021
Filing Date:
January 15, 2021
Export Citation:
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Assignee:
JIANGSU HENGRUI MEDICINE CO (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D419/14; A61K31/4365; A61K31/519; A61P35/00; C07B47/00; C07D291/08
Domestic Patent References:
WO2019050889A12019-03-14
WO2018049400A12018-03-15
Foreign References:
CN105153190A2015-12-16
CN103946222A2014-07-23
CN103068391A2013-04-24
CN105153190A2015-12-16
CN105051047A2015-11-11
CN103946222A2014-07-23
Other References:
LU YIPIN ET AL.,: "Rationally designed PI3Kα mutants to mimic ATR and their use to understand binding specificity of ATR inhibitors,", JOURNAL OF MOLECULAR BIOLOGY, vol. 429, no. 11, 20 April 2017 (2017-04-20), XP085041884, DOI: 10.1016/j.jmb.2017.04.006
Attorney, Agent or Firm:
GE CHENG & CO., LTD (CN)
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