FUSED HETEROCYCLIC DERIVATIVES HAVING SELECTIVE BACE1 INHIBITORY ACTIVITY

WIPO Patent Application WO/2020/009179

A1

The present invention provides a compound which has an effect of inhibiting amyloid β production, especially an effect of inhibiting BACE1, and which is useful as a therapeutic or prophylactic agent for diseases induced by production, secretion and/or deposition of amyloid β proteins. A compound of Formula (I) wherein Ring A is THP optionally substituted with R3 s or the like; R2 is C1-C3 alkyl optionally substituted with halogen; R3 is each independently C1-C8 alkyl optionally substituted with one or more group(s) selected from halogen, cyano, C1-C3 alkyloxy, C1-C3 haloalkyloxy, 3- to 6-membered non-aromatic carbocyclyl optionally substituted with halogen, and 3- to 6-membered non-aromatic heterocyclyl optionally substituted with halogen, or the like; t is integer from 0 to 3; A1 is CR6 or N; A2 is CR10 or N; R5 is a hydrogen atom or halogen; R6 is a hydrogen atom or the like; R8 is a hydrogen or the like; R10 is a hydrogen atom or the like; Ring B is pyrazine substituted with cyano or the like; or its pharmaceutically acceptable salt.

WO/2007/042325	ANTIBACTERIAL ACTIVE 5-CHINOLIN DERIVATIVE
JP2011126913	QUINOLINE DERIVATIVE AS PI3 KINASE INHIBITOR
JP4759679	Tetrahydrobenzotriazine derivative

YOSHIDA SYUHEI (JP)
TADANO GENTA (JP)
YAMADA TORU (JP)
OGUMA TAKUYA (JP)
KUSAKABE KEN-ICHI (JP)
ROMBOUTS FREDERIK (BE)
MISALE ANTONIO (ES)

PCT/JP2019/026598

January 09, 2020

July 04, 2019

Click for automatic bibliography generation  

SHIONOGI & CO (JP)
JANSSEN PHARMACEUTICA NV (BE)

C07D498/04; A61K31/5365; A61P25/28

WO2012107371A1

2012-08-16

JP2012250933A	2012-12-20
US20150166491A1	2015-06-18
JP2017071603A	2017-04-13

SUGITA, Ken-ichi et al. (JP)

View/Download PDF      PDF Help

Previous Patent: MODIFIED VINYL ALCOHOL POLYMER, METHOD FOR PRODUCING SAME, DISPERSION STABILIZER FOR SUSPENSION POLY...

Next Patent: PIPE JOINT