Title:
FUSED POLYCYCLIC HETEROCYCLE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1996/038446
Kind Code:
A1
Abstract:
Novel fused polycyclic heterocycle derivatives represented by general formula (I) or pharmacologically acceptable salts thereof which have an excellent antitumor effect, and a process for producing the same, wherein the ring A represents an optionally substituted monocyclic aromatic ring or a fused bicyclic ring wherein at least one of the rings is an aromatic ring; the ring B represents pyrrole, 4H-1,4-dioxane, 4H-1,4-thiazine or 4(1H)-pyridone; the ring C represents an optionally substituted monocyclic or fused bicyclic aromatic ring; and Y represents -e-f (wherein e represents lower alkylene; and f represents amidino, guanidino, or amino optionally substituted by hydroxy or lower alkyl optionally lower-alkylaminated); excluding a combination wherein the rings A and C are each an optionally substituted monocyclic aromatic ring.
Inventors:
SUGUMI HIROYUKI (JP)
NIIJIMA JUN (JP)
KOTAKE YOSHIHIKO (JP)
OKADA TOSHIMI (JP)
KAMATA JUN-ICHI (JP)
YOSHIMATSU KENTARO (JP)
NAGASU TAKESHI (JP)
NAKAMURA KATSUJI (JP)
UENAKA TOSHIMITSU (JP)
YAMAGUCHI ATSUMI (JP)
YOSHINO HIROSHI (JP)
KOYANAGI NOZOMU (JP)
KITO KYOSUKE (JP)
NIIJIMA JUN (JP)
KOTAKE YOSHIHIKO (JP)
OKADA TOSHIMI (JP)
KAMATA JUN-ICHI (JP)
YOSHIMATSU KENTARO (JP)
NAGASU TAKESHI (JP)
NAKAMURA KATSUJI (JP)
UENAKA TOSHIMITSU (JP)
YAMAGUCHI ATSUMI (JP)
YOSHINO HIROSHI (JP)
KOYANAGI NOZOMU (JP)
KITO KYOSUKE (JP)
Application Number:
PCT/JP1996/001487
Publication Date:
December 05, 1996
Filing Date:
May 31, 1996
Export Citation:
Assignee:
EISAI CO LTD (JP)
SUGUMI HIROYUKI (JP)
NIIJIMA JUN (JP)
KOTAKE YOSHIHIKO (JP)
OKADA TOSHIMI (JP)
KAMATA JUN ICHI (JP)
YOSHIMATSU KENTARO (JP)
NAGASU TAKESHI (JP)
NAKAMURA KATSUJI (JP)
UENAKA TOSHIMITSU (JP)
YAMAGUCHI ATSUMI (JP)
YOSHINO HIROSHI (JP)
KOYANAGI NOZOMU (JP)
KITO KYOSUKE (JP)
SUGUMI HIROYUKI (JP)
NIIJIMA JUN (JP)
KOTAKE YOSHIHIKO (JP)
OKADA TOSHIMI (JP)
KAMATA JUN ICHI (JP)
YOSHIMATSU KENTARO (JP)
NAGASU TAKESHI (JP)
NAKAMURA KATSUJI (JP)
UENAKA TOSHIMITSU (JP)
YAMAGUCHI ATSUMI (JP)
YOSHINO HIROSHI (JP)
KOYANAGI NOZOMU (JP)
KITO KYOSUKE (JP)
International Classes:
A61K31/522; A61K31/542; A61K31/585; A61P35/00; C07D471/06; C07D471/16; C07D487/06; C07D487/16; C07D491/16; C07D495/16; C07D498/06; C07D498/16; C07D513/06; C07D209/90; C07D215/00; C07D239/00; C07D265/34; C07D279/14; C07D311/00; C07D317/00; (IPC1-7): C07D471/06; A61K31/495; A61K31/535; A61K31/54; C07D471/16; C07D487/06; C07D491/16; C07D495/16; C07D498/06; C07D513/06
Foreign References:
| US3962438A | 1976-06-08 |
Other References:
ANTONINI I, ET AL.: "SYNTHESIS OF (DIALKYLAMINO)ALKYL-DISUBSTITUTED PYRIMIDO¬5,6,1-DE¾ACRIDINES, A NOVEL GROUP OF ANTICANCER AGENTS ACTIVE ON A MULTIDRUG RESISTANT CELL LINE", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 38, no. 17, 1 January 1995 (1995-01-01), US, pages 3282 - 3286, XP002948990, ISSN: 0022-2623, DOI: 10.1021/jm00017a013
CHEN Q, DEADLY L W, POLYA G M: "DIFFERENTIAL INHIBITION OF CYCLIC AMP-DEPENDENT PROTEIN KINASE, MYOSIN LIGHT CHAIN KINASE AND PROTEIN KINASE C BY AZAACRIDINE AND ACRIDINE DERIVATIVES", BIOLOGICAL CHEMISTRY HOPPE-SEYLER, WALTER DE GRUYTER, BERLIN, DE, vol. 375, no. 04, 1 April 1994 (1994-04-01), DE, pages 223 - 235, XP001018590, ISSN: 0177-3593
See also references of EP 0831094A4
CHEN Q, DEADLY L W, POLYA G M: "DIFFERENTIAL INHIBITION OF CYCLIC AMP-DEPENDENT PROTEIN KINASE, MYOSIN LIGHT CHAIN KINASE AND PROTEIN KINASE C BY AZAACRIDINE AND ACRIDINE DERIVATIVES", BIOLOGICAL CHEMISTRY HOPPE-SEYLER, WALTER DE GRUYTER, BERLIN, DE, vol. 375, no. 04, 1 April 1994 (1994-04-01), DE, pages 223 - 235, XP001018590, ISSN: 0177-3593
See also references of EP 0831094A4
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