Title:
FUSED PYRIDAZINE DERIVATIVE COMPOUNDS AND DRUGS CONTAINING THE COMPOUNDS AS THE ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2003/070707
Kind Code:
A1
Abstract:
Fused pyridazine derivatives represented by the following general formula (I) (wherein each symbol is as defined in the description) and pharmaceutically acceptable salts thereof: (I) Because of inhibiting poly(ADP-ribose)polymerase, the compounds represented by the general formula (I) are useful as preventives and/or remedies for various ischemic diseases (in brain, cord, heart, digestive tract, skeletal muscle, retina, etc.), inflammatory diseases (inflammatory bowel disease, multiple cerebrosclerosis, arthritis, etc.), neurodegenerative diseases (extrapyramidal disorder, Alzheimer’s disease, muscular dystrophy, lumbar spinal canal stenosis, etc.), diabetes, shock, head trauma, renal failure, hyperalgesia, etc. Moreover, these compounds are useful as agents against retroviruses (HIV, etc.) and sensitizers and immunosuppressants in treating cancer.
Inventors:
SEKO TAKUYA (JP)
TAKEUCHI JUN (JP)
TAKAHASHI SHINYA (JP)
KAMANAKA YOSHIHISA (JP)
KAMOSHIMA WATARU (JP)
TAKEUCHI JUN (JP)
TAKAHASHI SHINYA (JP)
KAMANAKA YOSHIHISA (JP)
KAMOSHIMA WATARU (JP)
Application Number:
PCT/JP2003/001694
Publication Date:
August 28, 2003
Filing Date:
February 18, 2003
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
SEKO TAKUYA (JP)
TAKEUCHI JUN (JP)
TAKAHASHI SHINYA (JP)
KAMANAKA YOSHIHISA (JP)
KAMOSHIMA WATARU (JP)
SEKO TAKUYA (JP)
TAKEUCHI JUN (JP)
TAKAHASHI SHINYA (JP)
KAMANAKA YOSHIHISA (JP)
KAMOSHIMA WATARU (JP)
International Classes:
A61K31/501; A61K31/502; A61K31/5025; A61K31/53; A61K31/5377; A61K31/541; A61K31/542; A61K31/55; A61K31/551; A61K31/554; A61P3/10; A61P7/08; A61P9/00; A61P9/10; A61P13/12; A61P25/00; A61P27/06; A61P29/00; A61P31/12; A61P31/18; A61P37/06; A61P43/00; C07D237/26; C07D237/32; C07D401/06; C07D401/12; C07D403/06; C07D403/12; C07D405/06; C07D405/12; C07D409/12; C07D417/12; C07D471/04; C07D487/04; C07D513/04; (IPC1-7): C07D237/32; C07D401/06; C07D401/12; C07D403/12; C07D405/06; C07D405/12; C07D409/12; C07D417/12; C07D471/04; C07D487/04; C07D513/04; A61K31/501; A61K31/502; A61K31/5025; A61K31/53; A61K31/5377; A61K31/541; A61K31/542; A61K31/55; A61K31/551; A61K31/554; A61P3/10; A61P7/08; A61P9/00; A61P9/10; A61P13/12; A61P25/00; A61P27/06; A61P29/00; A61P31/12; A61P31/18; A61P37/06; A61P43/00
Domestic Patent References:
| WO2000044726A1 | 2000-08-03 |
Other References:
MIGLIARA ONOFRIO ET AL.: "Hydrazinolysis of 4-acyl and 4-ethoxycarbonyl-3H-imidazo(1,5-b)pyridazine-5,7-(6H)diones: 8-oxo-1,4,7,8,-tetrahydropyridazino(4,5-c)pyridazine,8-oxo-7,8-dihydropyridazino(4,5-c)pyridazine and 5,8-dioxo-1,4,5,6,7,8-hexahydropyridazino(4,5-c)pyridazine deriv", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 17, no. 3, 1980, pages 529 - 531, XP002965894
CHEMICAL ABSTRACTS, vol. 65, 1966, Columbus, Ohio, US; abstract no. 13692G, HAHN W.E., RADZYNKIEWICZ R.: "Reactions of dimercaptomaleic acid derivatives. IV. Synthesis of some bicyclic systems containing 1,4-dithiin ring" XP002965895
CHEMICAL ABSTRACTS, vol. 65, 1966, Columbus, Ohio, US; abstract no. 13692G, HAHN W.E., RADZYNKIEWICZ R.: "Reactions of dimercaptomaleic acid derivatives. IV. Synthesis of some bicyclic systems containing 1,4-dithiin ring" XP002965895
Attorney, Agent or Firm:
Ohie, Kunihisa (Horiguchi No.2 Bldg. 7F 2-6,
Nihonbashi-Ningyocho 2-chom, Chuo-ku Tokyo, JP)
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