Title:
FUSED RING KIF18A INHIBITOR COMPOUND, PHARMACEUTICAL COMPOSITION, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/067675
Kind Code:
A1
Abstract:
The present invention provides a compound represented by formula (I), a pharmaceutical composition, and a preparation method therefor and use thereof. The compound has a good inhibitory effect on KIF18A, and can be used alone or in a binding complex with a microtubule to regulate the KIF18A protein for the treatment of KIF18A-mediated disorders and/or diseases, such as tumor diseases, and for the preparation of a drug used for such disorders or diseases.
Inventors:
LU BIAO (CN)
YANG FANGLONG (CN)
ZHANG CHEN (CN)
WANG SIQIN (CN)
JIN LEI (CN)
YANG FANGLONG (CN)
ZHANG CHEN (CN)
WANG SIQIN (CN)
JIN LEI (CN)
Application Number:
PCT/CN2023/121929
Publication Date:
April 04, 2024
Filing Date:
September 27, 2023
Export Citation:
Assignee:
CHANGCHUN GENESCIENCE PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D401/14; A61K31/455; A61K31/506; A61K31/675; A61P35/00; C07D401/04; C07D401/12; C07D405/04
Domestic Patent References:
| WO2023217233A1 | 2023-11-16 | |||
| WO2021026100A1 | 2021-02-11 | |||
| WO2020132651A1 | 2020-06-25 | |||
| WO2020132649A1 | 2020-06-25 |
Foreign References:
| CN116535400A | 2023-08-04 | |||
| CN113226473A | 2021-08-06 | |||
| CN114269731A | 2022-04-01 | |||
| CN114302880A | 2022-04-08 | |||
| US20220056015A1 | 2022-02-24 |
Attorney, Agent or Firm:
BEIJING ORIGINTELLIGENCE IP LAW FIRM (CN)
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