Title:
FUSED TETRACYCLIC COMPOUND AND APPLICATION THEREOF IN MEDICINE
Document Type and Number:
WIPO Patent Application WO/2021/143885
Kind Code:
A1
Abstract:
A fused tetracyclic compound and an application thereof in a medicine, and in particular, an application of the fused tetracyclic compound as a medicine for treating and/or preventing hepatitis B. Specifically, the invention relates to a compound as represented by general formula (I), or a stereoisomer, a tautomer, a nitrogen oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, wherein the variables are defined in the specification. The present invention further relates to use of the compound as represented by general formula (I), or the stereoisomer, the tautomer, the nitrogen oxide, the solvate, the metabolite, the pharmaceutically acceptable salt or the prodrug thereof as a medicine, and in particular, to use of the compound as a medicine for treating and/or preventing hepatitis B.
Inventors:
ZHANG YINGJUN (CN)
REN QINGYUN (CN)
HUANG JIANZHOU (CN)
YU FANGCAI (CN)
WANG YIFENG (CN)
REN QINGYUN (CN)
HUANG JIANZHOU (CN)
YU FANGCAI (CN)
WANG YIFENG (CN)
Application Number:
PCT/CN2021/072337
Publication Date:
July 22, 2021
Filing Date:
January 16, 2021
Export Citation:
Assignee:
DONGGUAN HEC NEW DRUG R&D CO LTD (CN)
SUNSHINE LAKE PHARMA CO LTD (CN)
SUNSHINE LAKE PHARMA CO LTD (CN)
International Classes:
C07D471/14; A61P31/12; A61P31/20; C07D221/18; C07D487/14; C07D493/14; C07D498/14
Domestic Patent References:
| WO2020063870A1 | 2020-04-02 | |||
| WO2015113990A1 | 2015-08-06 | |||
| WO2018019297A1 | 2018-02-01 | |||
| WO2018154466A1 | 2018-08-30 | |||
| WO2017216685A1 | 2017-12-21 |
Foreign References:
| CN108727378A | 2018-11-02 |
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