Title:
FUSED TETRACYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE
Document Type and Number:
WIPO Patent Application WO/2020/063870
Kind Code:
A1
Abstract:
There is provided a fused tetracyclic compound and application thereof in medicine, especially as a medicament for the treatment and/or prevention of hepatitis B. In particular, there is provided a compound having Formula (I) or a stereoisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, wherein each variable is as defined in the specification. There is provided the use of a compound having Formula (I) or a stereoisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof in medicine, especially as a medicament for the treatment and/or prevention of hepatitis B.
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Inventors:
HUANG JIANZHOU (CN)
REN QINGYUN (CN)
XIONG JINFENG (CN)
LIU YANG (CN)
ZHANG YINGJUN (CN)
REN QINGYUN (CN)
XIONG JINFENG (CN)
LIU YANG (CN)
ZHANG YINGJUN (CN)
Application Number:
PCT/CN2019/108562
Publication Date:
April 02, 2020
Filing Date:
September 27, 2019
Export Citation:
Assignee:
SUNSHINE LAKE PHARMA CO LTD (CN)
International Classes:
C07D471/04; A61K31/395; A61P31/12; A61P31/20
Domestic Patent References:
| WO2015113990A1 | 2015-08-06 | |||
| WO2017216685A1 | 2017-12-21 | |||
| WO2018019297A1 | 2018-02-01 | |||
| WO2018154466A1 | 2018-08-30 | |||
| WO2015113990A1 | 2015-08-06 | |||
| WO2017216685A1 | 2017-12-21 | |||
| WO2018019297A1 | 2018-02-01 | |||
| WO2018154466A1 | 2018-08-30 |
Foreign References:
| CN108727378A | 2018-11-02 | |||
| CN108727378A | 2018-11-02 |
Other References:
ELIEL, E.WILEN, S.: "Stereochemistry of Organic Compounds", 1994, JOHN WILEY&SONS, INC.
THOMAS SORRELL: "Organic Chemistry", 1999, UNIVERSITY SCIENCE BOOKS
MICHAEL B. SMITHJERRY MARCH: "March's Advanced Organic Chemistry", 2007, JOHN WILEY&SONS
L. W. DEADY, SYN. COMM., vol. 7, 1977, pages 509 - 514
T. HIGUCHIV STELLA: "Bioreversible Carriers in Drug Design", vol. 14, 1987, AMERICAN PHARMACEUTICAL ASSOCIATION AND PERGAMON PRESS, article "Pro-drugs as Novel Delivery Systems"
J. RAUTIO ET AL., PRODRUGS: DESIGN AND CLINICAL APPLICATIONS, NATURE REVIEW DRUG DISCOVERY, vol. 7, 2008, pages 255 - 270
S. J. HECKER ET AL.: "Prodrugs of Phosphates and Phosphonates", JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, 2008, pages 2328 - 2345, XP008148502, DOI: 10.1021/jm701260b
S. P. PARKER: "McGraw-Hill Dictionary of Chemical Terms", 1984, MCGRAW-HILL BOOK COMPANY
S. M. BERGE ET AL.: "J. Pharmaceutical Sciences", vol. 66, 1977, article "pharmaceutically acceptable salts", pages: 1 - 19
T. W. GREENE: "Protective Groups in Organic Synthesis", 1991, JOHN WILEY & SONS
P. J. KOCIENSKI: "Remington: The Science and Practice of Pharmacy", 2005, LIPPINCOTT WILLIAMS & WILKINS
"Encyclopedia of Pharmaceutical Technology", 1988, MARCEL DEKKER
See also references of EP 3856740A4
THOMAS SORRELL: "Organic Chemistry", 1999, UNIVERSITY SCIENCE BOOKS
MICHAEL B. SMITHJERRY MARCH: "March's Advanced Organic Chemistry", 2007, JOHN WILEY&SONS
L. W. DEADY, SYN. COMM., vol. 7, 1977, pages 509 - 514
T. HIGUCHIV STELLA: "Bioreversible Carriers in Drug Design", vol. 14, 1987, AMERICAN PHARMACEUTICAL ASSOCIATION AND PERGAMON PRESS, article "Pro-drugs as Novel Delivery Systems"
J. RAUTIO ET AL., PRODRUGS: DESIGN AND CLINICAL APPLICATIONS, NATURE REVIEW DRUG DISCOVERY, vol. 7, 2008, pages 255 - 270
S. J. HECKER ET AL.: "Prodrugs of Phosphates and Phosphonates", JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, 2008, pages 2328 - 2345, XP008148502, DOI: 10.1021/jm701260b
S. P. PARKER: "McGraw-Hill Dictionary of Chemical Terms", 1984, MCGRAW-HILL BOOK COMPANY
S. M. BERGE ET AL.: "J. Pharmaceutical Sciences", vol. 66, 1977, article "pharmaceutically acceptable salts", pages: 1 - 19
T. W. GREENE: "Protective Groups in Organic Synthesis", 1991, JOHN WILEY & SONS
P. J. KOCIENSKI: "Remington: The Science and Practice of Pharmacy", 2005, LIPPINCOTT WILLIAMS & WILKINS
"Encyclopedia of Pharmaceutical Technology", 1988, MARCEL DEKKER
See also references of EP 3856740A4
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