Title:
FUSED TRICYCLIC PARP1 INHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/099416
Kind Code:
A1
Abstract:
The present invention relates to a fused tricyclic PARP1 inhibitor, a preparation method therefor, and a use thereof. In particular, the present invention relates to a compound capable of inhibiting poly ADP-ribose polymerase activity, and a pharmaceutical composition and use thereof. The present invention relates in particular to compounds of formula (I), and also to pharmaceutical compositions comprising these compounds and to the use of these compounds in the preparation of a medicament for the prevention and/or treatment of a disease, in particular, diseased that can be ameliorated by inhibiting PARP1.
Inventors:
GAO SHANYUN (CN)
HOU YINGJIE (CN)
LI JINGJING (CN)
ZHANG CHAOBO (CN)
XU YANXIAO (CN)
TU WANGYANG (CN)
YU BING (CN)
ZHANG YIXIANG (CN)
LI LEPING (CN)
HOU YINGJIE (CN)
LI JINGJING (CN)
ZHANG CHAOBO (CN)
XU YANXIAO (CN)
TU WANGYANG (CN)
YU BING (CN)
ZHANG YIXIANG (CN)
LI LEPING (CN)
Application Number:
PCT/CN2023/130888
Publication Date:
May 16, 2024
Filing Date:
November 10, 2023
Export Citation:
Assignee:
HAIHE BIOPHARMA CO LTD (CN)
International Classes:
C07D487/04; A61K31/444; A61K31/519; A61P35/00; C07D401/14; C07D471/04
Domestic Patent References:
| WO2023217045A1 | 2023-11-16 | |||
| WO2023212219A1 | 2023-11-02 | |||
| WO2023169226A1 | 2023-09-14 | |||
| WO2023134647A1 | 2023-07-20 | |||
| WO2023122140A1 | 2023-06-29 | |||
| WO2023061406A1 | 2023-04-20 | |||
| WO2023056039A1 | 2023-04-06 | |||
| WO2023046034A1 | 2023-03-30 | |||
| WO2023025307A1 | 2023-03-02 | |||
| WO2011014681A1 | 2011-02-03 | |||
| WO2022225934A1 | 2022-10-27 |
Foreign References:
| CN107849040A | 2018-03-27 | |||
| CN102341394A | 2012-02-01 | |||
| CN102341399A | 2012-02-01 |
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
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