FUSION PEPTIDE COMPLEX COMPRISING TRANSMEMBRANE DOMAIN AND USE THEREOF

WIPO Patent Application WO/2024/076136

A1

The present invention relates to a fusion peptide complex comprising a transmembrane domain and use thereof, through which Gram-positive, Gram-negative and multidrug-resistant bacteria can be simultaneously captured in a specimen. Particularly, the present invention relates to a complex comprising a fusion peptide and further, a conjugate, the fusion peptide comprising a transmembrane domain and further, terminal amino acids at the ends of the transmembrane domain, in a membrane protein located in the cell membrane of cells and the membranes of intracellular organelles. The complex of the present invention is capable of capturing Gram-positive, Gram-negative, and multidrug-resistant bacteria within a short period of time without killing the bacteria, thus enabling rapid isolation of the captured bacteria from a sample, and also enables concentration and bacterial growth and thus can be used to obtain bacteria for bacteria identification or antibiotic susceptibility investigation. When the captured bacteria are immediately spread on an agar plate, each of the bacteria can also be isolated and cultured. The present invention can be used in various fields such as the diagnosis of infectious diseases caused by multidrug-resistant bacteria, medicinal use, quasi-drug use, and food and water quality testing.

LEE SO RA (KR)
YOO YOUNG DO (KR)

PCT/KR2023/015228

April 11, 2024

October 04, 2023

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ANDANTE FM CO LTD (KR)
UNIV KOREA RES & BUS FOUND (KR)

C07K14/00; C12N9/02

PARK, Hyuk (KR)

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